The allele frequencies of HLA-DRB1*0301 and HLA-DRB1*0406 in populations from various ethnic regions.

<p>These data information were collected from the Allele Frequency Net Database <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048594#pone.0048594-GonzalezGalarza1" target="_blank">[52]</a> except reference 25,27–30,33–34,38–39,41,45,51. Allele Frequency: Total number of copies of the allele in the population sample (Alleles/2n) in decimal format. a: data from Chinese National Marrow Donor Program(CMDP), b: data from Tzu Chi Taiwan Marrow Donor Registry (TCTMDR), c: data from USA Colorado Univ. Cord Blood Bank, d: data from Poland DKMS, e: data from Umbilical Cord Blood Bank of Bacelona, f: data in Allele frequency net was calculated from Phenotype Frequencies assuming Hardy-Weinberg proportions.</p

Comparison of the allele frequencies of HLA-DRB1*0301 among various groups.

<p>All subjects were classified by gender and age of onset of Parkinson’s disease (PD). △Pc<0.05 the allele frequency of HLA-DRB1*0301 in PD patients(total) vs. the one in healthy control(total), *Pc<0.05 the allele frequency of HLA-DRB1*0301 in PD patients (onset age ≤50) vs. the one in healthy control subgroup (onset age ≤50), # Pc<0.05 the allele frequency of HLA-DRB1*0301 in PD patients (onset age ≤50) vs. the one in PD patients (onset age >50).</p

Forest plots summarizing the Allele frequency of HLA-DRB1*0301 in Asian and European ancestry populations from various regions.

<p>The allele frequency was indicated as ES (95%CI). The distribution of HLA-DRB1*0301 was inequality in the worldwide populations, European ancestry populations presented a higher allele frequency of HLA-DRB1*0301 than African and Latin American ancestry populations and Asians (0.114 Vs. 0.071, 0.069, 0.041). In intra-Asian, Taiwanese presented a higher allele frequency of HLA-DRB1*0301 than populations in USA, mainland China, and Korea(0.091 Vs.0.054, 0.047, 0.022). However, HLA-DRB1*0301 was a rare allele in Japanese.</p

Basic information of patients with sporadic Parkinson’s disease (PD) and healthy controls.

<p>Basic information of patients with sporadic Parkinson’s disease (PD) and healthy controls.</p

Frequencies of HLA-DRB1 phenotypes and alleles in patients with Parkinson’s disease (PD) and healthy controls.

<p>Phenotype Frequency (Allele Frequency) was presented in every cell. “−”: the allele was not been detected. Phenotype Frequency: Percentage of individuals who have the allele (Individuals/N) in percentage format. Allele Frequency: Total number of copies of the allele in the population sample (Alleles/2N) in decimal format, Pc = correction of P value (Bonferroni adjustment), Pc<0.05 is considered as significant, ns = not significant. Patients had significant higher frequencies of HLA-DRB1*0301 and lower frequency of HLA-DRB1*0406 than healthy controls did.</p