Layout optimization for multi-bi-modulus materials system under multiple load cases

Financial support from the National Natural Science Foundation of China (Grant No. 51179164) and the Australian Research Council (Grant No. DP140103137) is acknowledged

PTENless means more

AbstractRecent studies indicate that certain key molecules that are vital for various developmental processes, such as Wnt, Shh, and Notch, cause cancer when dysregulated. PTEN, a tumor suppressor that antagonizes the PI3 kinase pathway, is the newest one on the list. The biological function of PTEN is evolutionarily conserved from C. elegans to humans, and the PTEN-controlled signaling pathway regulates cellular processes crucial for normal development, including cell proliferation, soma growth, cell death, and cell migration. In this review, we will focus on the function of PTEN in murine development and its role in regulating stem cell self-renewal and proliferation. We will summarize the organomegaly phenotypes associated with Pten tissue-specific deletion and discuss how PTEN controls organ size, a fundamental aspect of development. Last, we will review the role of PTEN in hormone-dependent, adult-onset mammary and prostate gland development

Cytokinesis and cancer: polo loves ROCK'n' Rho(A)

Cytokinesis is the last step of the M (mitosis) phase, yet it is crucial for the faithful division of one cell into two. Cytokinesis failure is often associated with cancer. Cytokinesis can be morphologically divided into four steps: cleavage furrow initiation, cleavage furrow ingression, midbody formation and abscission. Molecular studies have revealed that RhoA as well as its regulators and effectors are important players to ensure a successful cytokinesis. At the same time, Polo-like kinase 1 (Plk1) is an important kinase that can target many substrates and carry out different functions during mitosis, including cytokinesis. Recent studies are beginning to unveil a closer tie between Plk1 and RhoA networks. More specifically, Plk1 phosphorylates the centralspindlin complex Cyk4 and MKLP1/CHO1, thus recruiting RhoA guanine nucleotide-exchange factor (GEF) Ect2 through its phosphopeptide-binding BRCT domains. Ect2 itself can be phosphorylated by Plk1 in vitro. Plk1 can also phosphorylate another GEF MyoGEF to regulate RhoA activity. Once activated, RhoA-GTP will activate downstream effectors, including ROCK1 and ROCK2. ROCK2 is among the proteins that associate with Plk1 Polo-binding domain (PBD) in a large proteomic screen, and Plk1 can phosphorylate ROCK2 in vitro. We review current understandings of the interplay between Plk1, RhoA proteins and other proteins (e.g., NudC, MKLP2, PRC1, CEP55) involved in cytokinesis, with particular emphasis of its clinical implications in cancer

Effects of Stocking Rate on the Variability of Ecosystem Productivity in Desert Steppe

Management practices can increase biodiversity and generate corresponding compensatory effects on biomass production, which may reduce inter-annual variability of productivity in some grassland ecosystems. However, it remains unclear how stocking rate influences variability of ecosystem productivity. Four stocking rates were compared in a completely randomized block experiment in the desert steppe of Inner Mongolia, China: non-grazed control (0 sheep/ha/mo), lightly grazed (LG, 0.15 sheep/ha/mo), moderately grazed (MG, 0.30 sheep/ha/mo) and heavily grazed (HG, 0.45 sheep/ha/mo). Aboveground net primary productivity (ANPP) was measured every August for eight consecutive years (2004-2011). ANPP decreased significantly (P \u3c 0.05) with increasing stocking rate. Coefficients of variation for community (CVcomm) in LG and MG were lower than in the control and HG treatments. Coefficients of variation for both species (CVsp) and functional groups (CVPFG) showed logarithmic relationships with relative density (P \u3c 0.05). Thus, both stocking rate and annual precipitation significantly affected the biodiversity and stability of desert steppe in terms of interannual variability of ANPP. As in other grazed systems, our results indicate that grazing management can alter dominant species and functional group components within the grassland community

Comparison of the BCI Performance between the Semitransparent Face Pattern and the Traditional Face Pattern

Brain-computer interface (BCI) systems allow users to communicate with the external world by recognizing the brain activity without the assistance of the peripheral motor nervous system. P300-based BCI is one of the most common used BCI systems that can obtain high classification accuracy and information transfer rate (ITR). Face stimuli can result in large event-related potentials and improve the performance of P300-based BCI. However, previous studies on face stimuli focused mainly on the effect of various face types (i.e., face expression, face familiarity, and multifaces) on the BCI performance. Studies on the influence of face transparency differences are scarce. Therefore, we investigated the effect of semitransparent face pattern (STF-P) (the subject could see the target character when the stimuli were flashed) and traditional face pattern (F-P) (the subject could not see the target character when the stimuli were flashed) on the BCI performance from the transparency perspective. Results showed that STF-P obtained significantly higher classification accuracy and ITR than those of F-P (p < 0.05)