1 research outputs found
Biodegradable Polymer with Hydrolysis-Induced Zwitterions for Antibiofouling
Persistent protein
resistance is critical for marine antibiofouling. We have prepared
copolymer of 2-methylene-1,3-dioxepane (MDO), tertiary carboxybetaine
ester (TCB), and 7-methacryloyloxy-4-methylcoumarin (MAMC) via radical
ring-opening polymerization, where MDO, TCB, and MAMC make the polymer
degradable, protein resistible, and photo-cross-linkable, respectively. Our study shows that the polymer can well adhere to the substrate
with controlled degradation and water adsorption rate in artificial
seawater (ASW). Particularly, the polymer film can generate zwitterions
via surface hydrolysis in ASW. Quartz crystal microbalance with dissipation
measurements reveal that such hydrolysis-induced zwitterionic surface
can effectively resist nonspecific protein adsorption. Moreover, the
surface can inhibit the adhesion of marine bacteria <i>Pseudomonas</i> sp. and Vibrio alginolyticus as well
as clinical bacterium Escherichia coli