Signaling pathways in rheumatoid arthritis: implications for targeted therapy

Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease progression leads to joint deformity and associated loss of function, which significantly impacts the quality of life for sufferers and adds to losses in the labor force. In the past few decades, RA has attracted increased attention from researchers, the abnormal signaling pathways in RA are a very important research field in the diagnosis and treatment of RA, which provides important evidence for understanding this complex disease and developing novel RA-linked intervention targets. The current review intends to provide a comprehensive overview of RA, including a general introduction to the disease, historical events, epidemiology, risk factors, and pathological process, highlight the primary research progress of the disease and various signaling pathways and molecular mechanisms, including genetic factors, epigenetic factors, summarize the most recent developments in identifying novel signaling pathways in RA and new inhibitors for treating RA. therapeutic interventions including approved drugs, clinical drugs, pre-clinical drugs, and cutting-edge therapeutic technologies. These developments will hopefully drive progress in new strategically targeted therapies and hope to provide novel ideas for RA treatment options in the future

Effects of Supplementary Feeding on the Breeding Ecology of the Buff-Throated Partridge in a Tibetan Sacred Site, China

Our goal was to document effects of year-round supplemental feeding on breeding ecology of the Buff-throated Partridge, Tetraophasis szechenyii, within a Tibetan sacred site. We evaluated effects of supplemental feeding used as religious/cultural practices which could potentially aid conservation of endangered phasianids. We compared fed breeding groups to neighboring nonfed groups. Fed groups initiated first clutches significantly earlier than nonfed groups. Earlier laying groups within fed and nonfed groups showed significantly lower hatching rates than later groups; however, fed groups showed significantly higher hatching rates than nonfed groups laying in the same period. Earlier laying increased opportunities to renest. All six fed groups with clutch failures renested compared to only one of five nonfed groups with clutch failures. Fed female breeders showed significantly greater investment in their young with larger clutches and larger eggs, which likely increased survivability of early hatchlings. We observed no predation on birds at feeding sites and recorded only four cases of predation on incubating females, which showed no detectable difference between fed and nonfed groups. Ground-nesting birds typically face high risks of predation. Ten of the 48 groups nested in trees, which occurs in few phasianid species. Tree nests showed significantly higher hatching rates compared to ground nests; however, we found no significant difference in tree nesting between fed and nonfed groups. This partridge is one of four gallinaceous species with cooperative breeding. Breeding groups with helpers had significantly greater reproductive success than single pairs, and fed female breeders with helpers laid bigger eggs than single pairs. Comparing annual reproductive output per group, fed groups not only produced significantly more independent young (≥150 days post-hatching), their young hatched significantly earlier, which likely have greater reproductive value over later hatched young of nonfed groups. Supplemental feeding year-round is likely what enabled the successes of the fed partridges

Predicting suitable habitat of the Chinese monal (Lophophorus lhuysii) using ecological niche modeling in the Qionglai Mountains, China

Understanding the distribution and the extent of suitable habitats is crucial for wildlife conservation and management. Knowledge is limited regarding the natural habitats of the Chinese monal (Lophophorus lhuysii), which is a vulnerable Galliform species endemic to the high-montane areas of southwest China and a good candidate for being an umbrella species in the Qionglai Mountains. Using ecological niche modeling, we predicted current potential suitable habitats for the Chinese monal in the Qionglai Mountains with 64 presence points collected between 2005 and 2015. Suitable habitats of the Chinese monal were associated with about 31 mm precipitation of the driest quarter, about 15 °C of maximum temperature of the warmest month, and far from the nearest human residential locations (>5,000 m). The predicted suitable habitats of the Chinese monal covered an area of 2,490 km2, approximately 9.48% of the Qionglai Mountains, and was highly fragmented. 54.78% of the suitable habitats were under the protection of existing nature reserves and two conservation gaps were found. Based on these results, we provide four suggestions for the conservation management of the Chinese monal: (1) ad hoc surveys targeting potential suitable habitats to determine species occurrence, (2) more ecological studies regarding its dispersal capacity, (3) establishment of more corridors and green bridges across roads for facilitating species movement or dispersal, and (4) minimization of local disturbances

The complete mitogenome of the Amolops jinjiangensis (Anura: Ranidae)

We describe the mitochondrial genome sequence of a torrent frog, Amolops jinjiangensis. The mitogenome was extracted and assembled for the first time by restriction site-associated DNA sequencing (RAD-seq). The total length is 17,780 bp, containing 13 protein-coding genes (PCGs), two ribosomal RNA genes, 22 transfer RNA genes, and one control region. The gene rearrangement was detected as the W-OL-ANCY gene cluster which consisted with several published Amolops mitogenomes. The phylogenetic tree was constructed based on 13 protein-coding genes of A. jinjiangensis and 11 closely related species by Bayesian analyses

An Efficient Model for a Vast Number of Bird Species Identification Based on Acoustic Features

Birds have been widely considered crucial indicators of biodiversity. It is essential to identify bird species precisely for biodiversity surveys. With the rapid development of artificial intelligence, bird species identification has been facilitated by deep learning using audio samples. Prior studies mainly focused on identifying several bird species using deep learning or machine learning based on acoustic features. In this paper, we proposed a novel deep learning method to better identify a large number of bird species based on their call. The proposed method was made of LSTM (Long Short−Term Memory) with coordinate attention. More than 70,000 bird−call audio clips, including 264 bird species, were collected from Xeno−Canto. An evaluation experiment showed that our proposed network achieved 77.43% mean average precision (mAP), which indicates that our proposed network is valuable for automatically identifying a massive number of bird species based on acoustic features and avian biodiversity monitoring

Data for: Estimation of density distribution in unmarked populations using camera traps

Reliable estimates of species distribution and density are essential to ecology. Camera traps have revolutionized wildlife monitoring, and camera-trap data are increasingly used to study animal distribution and density. We propose a general framework and present a statistical model to estimate the distribution and density of species for which individuals lack identifying marks. Numbers recorded at traps allow spatial variation in density to be modelled, while distances of detected animals from the cameras allow correction for missed animals in the detection sector, using distance sampling. We test the model by simulating a camera-trap survey of a population of single animals, and we apply the model to data from a field study of Reeves's muntjac. The simulation indicated that the estimates of population density were unbiased, and the model performed well in depicting spatial variation in density. In the field study, the model estimated that the overall population density of Reeves's muntjac was 4.1 ind/km2, and mapped its density distribution across the study area. We provide a method to estimate unmarked species' density distribution using camera-trap data. Application of the model can help investigate the distribution and density of many ground-dwelling solitary animal populations lacking individually recognizable markings. We expect our method to provide an effective means for wildlife monitoring