Additional file 2 of Exploring the role and mechanism of Fuzi decoction in the treatment of osteoporosis by integrating network pharmacology and experimental verification

Additional file 2. The targets of the herbs

Additional file 4 of Exploring the role and mechanism of Fuzi decoction in the treatment of osteoporosis by integrating network pharmacology and experimental verification

Additional file 4. The common targets between FZD and osteoporosis

Additional file 5 of Exploring the role and mechanism of Fuzi decoction in the treatment of osteoporosis by integrating network pharmacology and experimental verification

Additional file 5. The pathways associated with the common targets

Additional file 3 of Exploring the role and mechanism of Fuzi decoction in the treatment of osteoporosis by integrating network pharmacology and experimental verification

Additional file 3. The gene targets of osteoporosis

Additional file 1 of Exploring the role and mechanism of Fuzi decoction in the treatment of osteoporosis by integrating network pharmacology and experimental verification

Additional file 1. The active components of FZD

Additional file 6 of Exploring the role and mechanism of Fuzi decoction in the treatment of osteoporosis by integrating network pharmacology and experimental verification

Additional file 6. The details of both the NF−kappa B signaling pathway and the reactive oxygen species

Compressed nerve roots in patients with foot drop.

<p>L5 nerve root was most frequently affected. Double or triple roots compression was a common condition.</p

A 54-years-old man, diagnosed as LDH and left foot drop.

<p>(A) Preoperative radiography. (B) Preoperative mid-sagittal MRI showed LDH on L4-S1. (C) Preoperative axial MRI of L4-5 showed the left L5 nerve root compression. (D) Preoperative axial MRI of L5-S1 showed the left S1 nerve root compression. (E) Postoperative radiography.</p

Obesity and Risk of Hip Fracture in Adults: A Meta-Analysis of Prospective Cohort Studies

<div><p>Background</p><p>Many observational studies assessed the association between obesity and risk of hip fracture in adults, but reported controversial results. Our goal was to evaluate the association between obesity and risk of hip fracture in adults by conducting a meta-analysis of prospective cohort studies.</p> <p>Methods</p><p>Three databases, PubMed, Embase and Web of Science, were searched through May 2012 to identify eligible cohort studies. Either a fixed- or a random-effects model was used to calculate the pooled relative risk (RR) with its 95% confidence interval (95%CI).</p> <p>Results</p><p>Fifteen prospective cohort studies involving a total 3,126,313 participants were finally included into this meta-analysis. Overall, adults with obesity compared with the normal weight group had a significantly decreased risk of hip fracture (RR: 0.66, 95% CI 0.57 to 0.77, P<0.001). Meta-analyses by the adjusted status of RRs also suggested adults with obesity compared with the reference group had a significantly decreased risk of hip fracture (adjusted RR: 0.48, 95% CI 0.39 to 0.58, P<0.001; unadjusted RR: 0.66, 95% CI 0.56 to 0.78, P<0.001). Subgroup analyses by gender suggested individuals with obesity had a significantly decreased risk for developing hip fracture compared with the reference group in both men (RR 0.54, 95% CI 0.48 to 0.60, P<0.001) and women (RR 0.70, 95% CI 0.58 to 0.84, P<0.001). No evidence of publication bias was observed in this meta-analysis.</p> <p>Conclusions</p><p>This meta-analysis of prospective cohort studies suggests that obesity significantly decreases the risk of hip fracture in adults, and obesity is probably a protective factor of hip fracture in adults.</p> </div

Summary of the results in the meta-analysis of adult obesity and risk of hip fracture.

<p>(NA = not applicable).</p