Research on Launch Dynamics Modeling and Simulating for Surface-to-air Missile Supported by Adapter

The launch dynamics analysis model of surface-to-air missile supported by the adapter was established, and the model was verified by test data. Simulation analysis shows: the missile begins to generate pitch angular speed at semi-constrained state after mid-adapter leave the tube, and the speed increases with distance between the mid-adapter and the rear adapter, and as the thrust of the engine increases to decreases, as the launch angle decreases, the missile's pitch angular speed increases, gravity is the main cause of the launch disturbance in the direction of the pitching

Removal of Mercury from Coal-Fired Flue Gas and Its Sulfur Tolerance Characteristics by Mn, Ce Modified γ-Al2O3 Catalyst

Mercury pollution in the atmospheric environment is a matter of international concern. Mercury in coal-fired flue gas is the first human mercury emission source and has become the focus of national mercury pollution control. The catalytic performance of zerovalent mercury (Hg0) in coal-fired flue gas was studied by using manganese-cerium-aluminum oxide as catalyst. The effects of metal loading ratio, reaction temperature, calcination temperature, and O2 and SO2 concentration on the efficiency of Hg0 catalytic removal were investigated, and the Mn-Ce/γ-Al2O3 catalysts before and after the reaction were characterized by BET, SEM, XRD, and XPS to analyze the physicochemical properties of the samples. The results show that the mercury removal efficiency of the composite catalyst with Mn, Ce, and Al as the active component is higher than that of the single metal catalyst. The catalytic activity of Mn0.1Ce0.02Al is the best, the optimum reaction temperature is 150°C, the optimum calcination temperature is 400°C, and the O2 concentration in the conventional flue gas condition satisfies the effective oxidation of Hg0; SO2 in the flue gas can seriously inhibit the oxidation of Hg0

Field Study on Indoor Thermal Environments of Monastic Houses and Thermal Comfort of Monks

Monastic houses are an essential part of the Tibetan monastic system in China. In this study, the monastic houses of Labrang in the Tibetan region of Gannan were used as the research objects. Physical parameters such as indoor temperature, humidity, and radiation temperature of the monastic houses were measured. The measured results were compared with the standard values, while the air temperature was linearly fitted using TSV, PMV, and aPMV. The results show that the temperature inside and outside the monastic houses fluctuates considerably; the theoretical thermal neutral temperature of the tested monks in winter is 22.46 °C, which is higher than the measured thermal neutral temperature in winter of 16.43 °C. When analyzing the results, it was found that the local climate, dress code, and the monks’ specific habits all impact the perception of thermal comfort, which creates a discrepancy between the accurate results and the standard values. The above findings provide a more comprehensive reference for the thermal comfort requirements of the monks in cold areas, which can be used as a guide for the improvement and evaluation of the monastic houses in cold areas

Metastasis organotropism in colorectal cancer: advancing toward innovative therapies

Abstract Distant metastasis remains a leading cause of mortality among patients with colorectal cancer (CRC). Organotropism, referring to the propensity of metastasis to target specific organs, is a well-documented phenomenon in CRC, with the liver, lungs, and peritoneum being preferred sites. Prior to establishing premetastatic niches within host organs, CRC cells secrete substances that promote metastatic organotropism. Given the pivotal role of organotropism in CRC metastasis, a comprehensive understanding of its molecular underpinnings is crucial for biomarker-based diagnosis, innovative treatment development, and ultimately, improved patient outcomes. In this review, we focus on metabolic reprogramming, tumor-derived exosomes, the immune system, and cancer cell-organ interactions to outline the molecular mechanisms of CRC organotropic metastasis. Furthermore, we consider the prospect of targeting metastatic organotropism for CRC therapy

Exploiting Polyphenol-Mediated Redox Reorientation in Cancer Therapy

Polyphenol, one of the major components that exert the therapeutic effect of Chinese herbal medicine (CHM), comprises several categories, including flavonoids, phenolic acids, lignans and stilbenes, and has long been studied in oncology due to its significant efficacy against cancers in vitro and in vivo. Recent evidence has linked this antitumor activity to the role of polyphenols in the modulation of redox homeostasis (e.g., pro/antioxidative effect) in cancer cells. Dysregulation of redox homeostasis could lead to the overproduction of reactive oxygen species (ROS), resulting in oxidative stress, which is essential for many aspects of tumors, such as tumorigenesis, progression, and drug resistance. Thus, investigating the ROS-mediated anticancer properties of polyphenols is beneficial for the discovery and development of novel pharmacologic agents. In this review, we summarized these extensively studied polyphenols and discussed the regulatory mechanisms related to the modulation of redox homeostasis that are involved in their antitumor property. In addition, we discussed novel technologies and strategies that could promote the development of CHM-derived polyphenols to improve their versatile anticancer properties, including the development of novel delivery systems, chemical modification, and combination with other agents

Oncofetal reprogramming in tumor development and progression: novel insights into cancer therapy

Abstract Emerging evidence indicates that cancer cells can mimic characteristics of embryonic development, promoting their development and progression. Cancer cells share features with embryonic development, characterized by robust proliferation and differentiation regulated by signaling pathways such as Wnt, Notch, hedgehog, and Hippo signaling. In certain phase, these cells also mimic embryonic diapause and fertilized egg implantation to evade treatments or immune elimination and promote metastasis. Additionally, the upregulation of ATP‐binding cassette (ABC) transporters, including multidrug resistance protein 1 (MDR1), multidrug resistance‐associated protein 1 (MRP1), and breast cancer‐resistant protein (BCRP), in drug‐resistant cancer cells, analogous to their role in placental development, may facilitate chemotherapy efflux, further resulting in treatment resistance. In this review, we concentrate on the underlying mechanisms that contribute to tumor development and progression from the perspective of embryonic development, encompassing the dysregulation of developmental signaling pathways, the emergence of dormant cancer cells, immune microenvironment remodeling, and the hyperactivation of ABC transporters. Furthermore, we synthesize and emphasize the connections between cancer hallmarks and embryonic development, offering novel insights for the development of innovative cancer treatment strategies

Interleukin-10 inhibits interleukin-1β production and inflammasome activation of microglia in epileptic seizures

Abstract Background Microglia are important for secreting chemical mediators of inflammatory responses in the central nervous system. Interleukin (IL)-10 and IL-1β secreted by glial cells support neuronal functions, but the related mechanisms remain vague. Our goal was to demonstrate the efficacy of IL-10 in suppressing IL-1β and in inflammasome activation in mice with epileptic seizure based on an epileptic-seizure mouse model. Methods In this study, mice in which epileptic seizures were induced by administering picrotoxin (PTX) were used as a case group, and mice injected with saline were employed as the control group. The expression of nucleic acids, cytokines, or signaling pathways was detected by reverse transcription-polymerase chain reaction (RT-PCR), enzyme-linked immunosorbent assay (ELISA), flow cytometry, and Western blotting. Results Our results demonstrated that IL-10 inhibits IL-1β production through two distinct mechanisms: (1) Treatment with lipopolysaccharides (LPS) results in IL-10 overexpression in microglia and reduced NLRP3 inflammasome activity, thus inhibiting caspase-1-related IL-1β maturation; (2) next, autocrine IL-10 was found to subsequently promote signal transducer and activator of transcription-3 (STAT-3), reducing amounts of pro-IL-1β. Conclusions Our results indicate that IL-10 is potentially effective in the treatment of inflammation encephalopathy, and suggest the potential usefulness of IL-10 for treating autoimmune or inflammatory ailments

RET/PTC Rearrangements Are Associated with Elevated Postoperative TSH Levels and Multifocal Lesions in Papillary Thyroid Cancer without Concomitant Thyroid Benign Disease

<div><p>RET/PTC rearrangements, resulting in aberrant activity of the RET protein tyrosine kinase receptor, occur exclusively in papillary thyroid cancer (PTC). In this study, we examined the association between RET/PTC rearrangements and thyroid hormone homeostasis, and explored whether concomitant diseases such as nodular goiter and Hashimoto's thyroiditis influenced this association. A total of 114 patients diagnosed with PTC were enrolled in this study. Thyroid hormone levels, clinicopathological parameters and lifestyle were obtained through medical records and surgical pathology reports. RET/PTC rearrangements were detected using TaqMan RT-PCR and validated by direct sequencing. No RET/PTC rearrangements were detected in benign thyroid tissues. RET/PTC rearrangements were detected in 23.68% (27/114) of PTC tissues. No association between thyroid function, clinicopathological parameters and lifestyle was observed either in total thyroid cancer patients or the subgroup of patients with concomitant disease. In the subgroup of PTC patients without concomitant disease, RET/PTC rearrangement was associated with multifocal cancer (P = 0.018). RET/PTC rearrangement was also correlated with higher TSH levels at one month post-surgery (P = 0.037). Based on likelihood-ratio regression analysis, the RET/PTC-positive PTC cases showed an increased risk of multifocal cancers in the thyroid gland (OR = 5.57, 95% CI, 1.39–22.33). Our findings suggest that concomitant diseases such as nodular goiter and Hashimoto's thyroiditis in PTC may be a confounding factor when examining the effects of RET/PTC rearrangements. Excluding the potential effect of this confounding factor showed that RET/PTC may confer an increased risk for the development of multifocal cancers in the thyroid gland. Aberrantly increased post-operative levels of TSH were also associated with RET/PTC rearrangement. Together, our data provides useful information for the treatment of papillary thyroid cancer.</p></div

Association between RET/PTC rearrangement and pathological parameters in thyroid cancer patients.

<p>Association between RET/PTC rearrangement and pathological parameters in thyroid cancer patients.</p