A pathway analysis of genome-wide association study highlights novel type 2 diabetes risk pathways.

Genome-wide association studies (GWAS) have been widely used to identify common type 2 diabetes (T2D) variants. However, the known variants just explain less than 20% of the overall estimated genetic contribution to T2D. Pathway-based methods have been applied into T2D GWAS datasets to investigate the biological mechanisms and reported some novel T2D risk pathways. However, few pathways were shared in these studies. Here, we performed a pathway analysis using the summary results from a large-scale meta-analysis of T2D GWAS to investigate more genetic signals in T2D. Here, we selected PLNK and VEGAS to perform the gene-based test and WebGestalt to perform the pathway-based test. We identified 8 shared KEGG pathways after correction for multiple tests in both methods. We confirm previous findings, and highlight some new T2D risk pathways. We believe that our results may be helpful to study the genetic mechanisms of T2D

Multi-scale Deep Learning Architectures for Person Re-identification

Person Re-identification (re-id) aims to match people across non-overlapping camera views in a public space. It is a challenging problem because many people captured in surveillance videos wear similar clothes. Consequently, the differences in their appearance are often subtle and only detectable at the right location and scales. Existing re-id models, particularly the recently proposed deep learning based ones match people at a single scale. In contrast, in this paper, a novel multi-scale deep learning model is proposed. Our model is able to learn deep discriminative feature representations at different scales and automatically determine the most suitable scales for matching. The importance of different spatial locations for extracting discriminative features is also learned explicitly. Experiments are carried out to demonstrate that the proposed model outperforms the state-of-the art on a number of benchmarksComment: 9 pages, 3 figures, accepted by ICCV 201