1 research outputs found
Fe-Promoted Chlorobenzylation of Terminal Alkynes through Benzylic C(sp<sup>3</sup>)–H Bond Functionalization
A chlorobenzylation
of terminal alkynes through FeÂ(II)-promoted
benzylic CÂ(sp<sup>3</sup>)–H bond functionalization in the
presence of NCS as a chloride source was developed. Compared with
previous methods to prepare polysubstituted alkenyl halides, the presented
procedure provides an efficient alternative with high atom and step
economy under mild conditions. The transformation was established
to proceed through a single-electron transfer (SET) process with benzyl
cations as key intermediates