The Architecture of a Novel Weighted Network: Knowledge Network

Networked structure emerged from a wide range of fields such as biological systems, World Wide Web and technological infrastructure. A deeply insight into the topological complexity of these networks has been gained. Some works start to pay attention to the weighted network, like the world-wide airport network and the collaboration network, where links are not binary, but have intensities. Here, we construct a novel knowledge network, through which we take the first step to uncover the topological structure of the knowledge system. Furthermore, the network is extended to the weighted one by assigning weights to the edges. Thus, we also investigate the relationship between the intensity of edges and the topological structure. These results provide a novel description to understand the hierarchies and organizational principles in knowledge system, and the interaction between the intensity of edges and topological structure. This system also provides a good paradigm to study weighted networks.Comment: 5 figures 11 page

Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2 and cell proliferation via Gαq-mediated mechanism

Dimerization of G protein-coupled receptors (GPCRs) is crucial for receptor function including agonist affinity, efficacy, trafficking and specificity of signal transduction, including G protein coupling. Emerging data suggest that the cardiovascular system is the main target of apelin, which exerts an overall neuroprotective role, and is a positive regulator of angiotensin-converting enzyme 2 (ACE2) in heart failure. Moreover, ACE2 cleaves off C-terminal residues of vasoactive peptides including apelin-13, and neurotensin that activate the apelin receptor (APJ) and neurotensin receptor 1 (NTSR1) respectively, that belong to the A class of GPCRs. Therefore, based on the similar mode of modification by ACE2 at peptide level, the homology at amino acid level and the capability of forming dimers with other GPCRs, we have been suggested that APJ and NTSR1 can form a functional heterodimer. Using co-immunoprecipitation, BRET and FRET, we provided conclusive evidence of heterodimerization between APJ and NTSR1 in a constitutive and induced form. Upon agonist stimulation, hetrodimerization enhanced ERK1/2 activation and increased proliferation via activation of Gq α-subunits. These novel data provide evidence for a physiological role of APJ/NTSR1 heterodimers in terms of ERK1/2 activation and increased intracellular calcium and induced cell proliferation and provide potential new pharmaceutical targets for cardiovascular disease. © 2014 The Authors

Charge pumping in magnetic tunnel junctions: Scattering theory

We study theoretically the charge transport pumped by magnetization dynamics through epitaxial FIF and FNIF magnetic tunnel junctions (F: Ferromagnet, I: Insulator, N: Normal metal). We predict a small but measurable DC pumping voltage under ferromagnetic resonance conditions for collinear magnetization configurations, which may change sign as function of barrier parameters. A much larger AC pumping voltage is expected when the magnetizations are at right angles. Quantum size effects are predicted for an FNIF structure as a function of the normal layer thickness.Comment: 4 pages, 3 figures. to be published on Physical Review B Rapid Communicatio

Local Measurement of Current Density by Magneto-Optical Current Reconstruction in Normally and Overpressure Processed Bi-2223 Tapes

Magneto-optical current reconstruction has been used for detailed analysis of the local critical current density (Jc) variation in monocore Bi-2223 tapes. We find, even in high quality tapes with bulk transport Jc ~ 40 kA/cm^2 (77K, 0T), that there exist local regions which possess current densities of more than 200 kA/cm^2. Overpressure processing at 148 bar significantly improved Jc to 48 kA/cm^2 by improving the connectivity. For the overpressure-processed sample we find that the current distribution is more uniform and that the maximum local current density at 77 K is increased almost to 300 kA/cm^2.Comment: Presented at Applied Superconductivity Conference, Houston, August 4th -9th, 200

Microarray-based ultra-high resolution discovery of genomic deletion mutations

BACKGROUND: Oligonucleotide microarray-based comparative genomic hybridization (CGH) offers an attractive possible route for the rapid and cost-effective genome-wide discovery of deletion mutations. CGH typically involves comparison of the hybridization intensities of genomic DNA samples with microarray chip representations of entire genomes, and has widespread potential application in experimental research and medical diagnostics. However, the power to detect small deletions is low. RESULTS: Here we use a graduated series of Arabidopsis thaliana genomic deletion mutations (of sizes ranging from 4 bp to ~5 kb) to optimize CGH-based genomic deletion detection. We show that the power to detect smaller deletions (4, 28 and 104 bp) depends upon oligonucleotide density (essentially the number of genome-representative oligonucleotides on the microarray chip), and determine the oligonucleotide spacings necessary to guarantee detection of deletions of specified size. CONCLUSIONS: Our findings will enhance a wide range of research and clinical applications, and in particular will aid in the discovery of genomic deletions in the absence of a priori knowledge of their existence

Reproducibility of corpus cavernosum electromyography in healthy young man

Research on reproducibility of corpus cavernosum electromyography (CC-EMG) is relevant because reproducible signals indicate a biological phenomenon and not an artefact. Reproducible signals are also required to use CC-EMG as a diagnostic tool for erectile dysfunction. The aim of this study was to assess the reproducibility of CC-EMG in healthy young men under well-controlled conditions.\u

Estudio etnomatemático en la confección de muebles típicos de la vela de coro

La investigación parte de la interrogante: ¿está presente conocimiento matemático en la confección de muebles típicos de artesanía veleña? y más específicamente, ¿es posible encontrar aspectos geométricos en la fabricación de estos muebles? Teóricamente se sustentó en House, Trentacosta y Burke (citados por Shirley, 2001) quienes asumen que la diversidad cultural puede ser incorporada en la pedagogía. Metodológicamente atiende a un estudio etnomatemático (D´Ambrosio, 1990) con enfoque crítico/interpretativo, dividido en cuatro fases: marco teórico, escenario, trabajo de campo y análisis.Resultados permitieron evidenciar que artesanos muestran habilidades en construcción de muebles donde están presentes elementos geométricos: circunferencia, polígonos rectangulares, simetría, rectas paralelas y medidas de ángulos. Partiendo de ello, se diseña propuesta pedagógica que recrea la enseñanza matemática con utilidad social

Study of the Hindrance Effect in Sub-barrier Fusion Reactions

We have measured the fusion cross sections of the 12C(13C, p)24Na reaction through off-line measurement of the beta-decay of 24Na using the beta-gamma coincidence method. Our new measurements in the energy range of Ec.m. = 2.6-3.0 MeV do not show an obvious S-factor maximum but a plateau. Comparison between this work and various models is presented.Comment: 3 pages, 3 figures, Talk at the "10th International Conference on Nucleus-Nucleus Collisions", Beijing, 16-21 August 200

Evolutions of helical edge states in disordered HgTe/CdTe quantum wells

We study the evolutions of the nonmagnetic disorder-induced edge states with the disorder strength in the HgTe/CdTe quantum wells. From the supercell band structures and wave-functions, it is clearly shown that the conducting helical edge states, which are responsible for the reported quantized conductance plateau, appear above a critical disorder strength after a gap-closing phase transition. These edge states are then found to decline with the increase of disorder strength in a stepwise pattern due to the finite-width effect, where the opposite edges couple with each other through the localized states in the bulk. This is in sharp contrast with the localization of the edge states themselves if magnetic disorders are doped which breaks the time-reversal symmetry. The size-independent boundary of the topological phase is obtained by scaling analysis, and an Anderson transition to an Anderson insulator at even stronger disorder is identified, in-between of which, a metallic phase is found to separate the two topologically distinct phases.Comment: 7 pages, 5 figure