Ethyl 6-(2-chloro­phen­yl)-4-methyl-1-(3-oxobut­yl)-2-thioxo-1,2,3,6-tetra­hydro­pyrimidine-5-carboxyl­ate

In the title mol­ecule, C18H21ClN2O3S, the pyrimidine ring exhibits a half-chair conformation. The ethyl group is disordered between two positions in a ratio 0.74:0.26. In the crystal structure, the mol­ecules are linked into chains along the a axis by N—H⋯O hydrogen bonds

Edge and corner states in 2D non-Abelian topological insulators from an eigenvector frame rotation perspective

We propose the concept of 2D non-Abelian topological insulator which can explain the energy distributions of the edge states and corner states in systems with parity-time symmetry. From the viewpoint of non-Abelian band topology, we establish the constraints on the 2D Zak phase and polarization. We demonstrate that the corner states in some 2D systems can be explained as the boundary mode of the 1D edge states arising from the multi-band non-Abelian topology of the system. We also propose the use of off-diagonal Berry phase as complementary information to assist the prediction of edge states in non-Abelian topological insulators. Our work provides an alternative approach to study edge and corner modes and this idea can be extended to 3D systems

The Evalution to the Comprehensive Competitiveness of Industry Clusters and its Industrial Upgrading: an investigation to the non-weaven cluster in Pengchang town of Xiantao city in Hubei province

Almost all industry clusters where the competitive advantage is the low cost of labor and natural resources are facing the problem of clusters’ upgrading and path controlling in the global value chain. In this paper, a non-woven cluster in Pengchang town of Xiantao city in Hubei province was chosen to be a key research target. The problems in this cluster can reflect the common characteristics of the labor-intensive clusters in China. After evaluating the mature degree and potential threatens of Pengchang cluster, a viewpoint of re-establishing competitive advantage, as well as the thinking way of making industry policies from the view of supplying generic technology was put forward. Keywords: industry clusters, generic technology, cooperative innovation Résumé Les groupes industriels de notre pays, développés grâce aux avantages de la main-d’oeuvre et des ressources naturelles, confrontent tous les problème de la progression dans la chaîne de valeur industrielle mondiale et de l’augmentation de la force de contrôle. L’auteur a choisi le groupe industriel de la toile non-tissée de Pengchang comme objet d’étude, parce que ses problème apparus dans son développement sont représentatifs dans notre pays. Après avoir évalué son niveau de développement et les dangers latents, l’auteur propose de remettre en valeur ses avandages. De plus il avance, sous l’angle de l’alimentation de la techique générale du groupe, l’idée d’élaborer des politiques correspondantes. Mots-clés : groupe industriel, technique générale, coopération et innovation 摘 要 中國利用勞動力和自然資源優勢而發展起來的產業集群都面臨在全球產業價值鏈中的升級和集群路徑控制力的提升問題。本文選擇了湖北仙桃市彭場鎮無紡布產業集群作為重點研究對象，這個產業集群發展中的問題在中國具有一定的代表性。在對此產業集群的發展成熟度和潛在威脅進行評估的基礎上，提出了重塑其競爭優勢的觀點，並從集群共性技術供應這個角度提出了制定相應產業政策的思路。 關鍵詞：產業集群；共性技術；合作創

Four-band non-Abelian topological insulator and its experimental realization

Very recently, increasing attention has been focused on non-Abelian topological charges, e.g. the quaternion group Q8. Different from Abelian topological band insulators, these systems involve multiple tangled bulk bandgaps and support non-trivial edge states that manifest the non-Abelian topological features. Furthermore, a system with even or odd number of bands will exhibit significant difference in non-Abelian topological classifications. Up to now, there is scant research investigating the even-band non-Abelian topological insulators. Here, we both theoretically explored and experimentally realized a four-band PT (inversion and time-reversal) symmetric system, where two new classes of topological charges as well as edge states are comprehensively studied. We illustrate their difference from four-dimensional rotation senses on the stereographically projected Clifford tori. We show the evolution of bulk topology by extending the 1D Hamiltonian onto a 2D plane and provide the accompanying edge state distributions following an analytical method. Our work presents an exhaustive study of four-band non-Abelian topological insulators and paves the way to other even band systems.Comment: Main text and supplementary informatio

Sulfated tyrosines 27 and 29 in the N-terminus of human CXCR3 participate in binding native IP-10

Aim: Human CXCR3, a seven-transmembrane segment (7TMS), is predominantly expressed in Th1-mediated responses. Interferon-γ-inducible protein 10 (IP-10) is an important ligand for CXCR3. Their interaction is pivotal for leukocyte migration and activation. Tyrosine sulfation in 7TMS is a posttranslational modification that contributes substantially to ligand binding. We aimed to study the role of tyrosine sulfation of CXCR3 in the protein's binding to IP-10. Methods: Plasmids encoding CXCR3 and its mutants were prepared by PCR and site-directed mutagenesis. HEK 293T cells were transfected with plasmids encoding CXCR3 or its variants using calcium phosphate. Transfected cells were labeled with [35S]-cysteine and methionine or [35S]-Na2SO3 and then analyzed by immunoprecipitation to measure sulfation. Experiments with 125I-labeled IP-10 were carried out to evaluate the affinity of CXCR3 for its ligand. Calcium influx assays were used to measure intercellular signal transduction. Results: Our data show that sulfate moieties are added to tyrosines 27 and 29 of CXCR3. Mutation of these two tyrosines to phenylalanines substantially decreases binding of CXCR3 to IP-10 and appears to eliminate the associated signal transduction. Tyrosine sulfation of CXCR3 is enhanced by tyrosyl protein sulfotransferases (TPSTs), and it is weakened by shRNA constructs. The binding ability of CXCR3 to IP-10 is increased by TPSTs and decreased by shRNAs. Conclusions: This study identifies two sulfated tyrosines in the N-terminus of CXCR3 as part of the binding site for IP-10, and it underscores the fact that tyrosine sulfation in the N-termini of 7TMS receptors is functionally important for ligand interactions. Our study suggests a molecular target for inhibiting this ligand-receptor interaction