2-(4-tert-Butyl­phen­yl)-5-{3,4-dibutoxy-5-[5-(4-tert-butyl­phen­yl)-1,3,4-oxadiazol-2-yl]-2-thienyl}-1,3,4-oxadiazole

In the title compound, C36H44N4O4S, the dihedral angles between the central thio­phene ring and the pendent oxadiazole rings are 12.7 (2) and 13.7 (2)°, and the dihedral angles between the oxadiazole rings and their adjacent benzene rings are 6.1 (2) and 17.5 (2)°. An intra­molecular C—H⋯O inter­action may help to establish the conformation

Ethyl 2-(2-hy­droxy-5-nitro­phen­yl)acetate

In the crystal structure of the title compound, C10H11NO5, inter­molecular O—H⋯O hydrogen bonds link the mol­ecules into chains along the b-axis direction. Weak C—H.·O hydrogen bonds also occur

3-[4-(Trifluoro­meth­yl)phen­yl]propanoic acid

In crystal of the the title compound, C10H9F3O2, inversion dimers linked by pairs of O—H⋯O hydrogen bonds occur

4-Bromo-2-[1-(4-eth­oxy­phen­yl)-1-methyl­eth­yl]-1-methyl­benzene

In title compound, C18H21BrO, the dihedral angle between two rings is 85.72°. No classical hydrogen bonds are found and only van der Waals forces stabilize the crystal packing

Ethyl 5-methyl­imidazo[1,2-a]pyridine-2-carboxyl­ate

The title compound, C11H12N2O2, was synthesized from the reaction of 6-methyl­pyridin-2-amine and ethyl 3-bromo-2-oxopropionate. In the mol­ecular structure, the six- and five-membered rings are individually almost planar with r.m.s. deviations of 0.003 and 0.002 Å, respectively. The two rings are almost coplanar, the dihedral angle between their planes being 1.4 (3)°. Inter­molecular C—H⋯O and C—H⋯N hydrogen bonds are present in the crystal structure

Photonic Localization of Interface Modes at the Boundary between Metal and Fibonacci Quasi-Periodic Structure

We investigated on the interface modes in a heterostructure consisting of a semi-infinite metallic layer and a semi-infinite Fibonacci quasi-periodic structure. Various properties of the interface modes, such as their spatial localizations, self-similarities, and multifractal properties are studied. The interface modes decay exponentially in different ways and the modes in the lower stable gap possess highest spatial localization. A localization index is introduced to understand the localization properties of the interface modes. We found that the localization index of the interface modes in the upper stable gap will converge to two slightly different constants according to the parity of the Fibonacci generation. In addition, the localization-delocalization transition is also found in the interface modes of the transient gap.Comment: 20 pages, 5figure

Anterior Gradient 2 is a Significant Prognostic Biomarker in Bone Metastasis of Breast Cancer

Background: The study aimed to detect DEGs associated with BRCA bone metastasis, filter prognosis biomarkers, and explore possible pathways.Methods: GSE175692 dataset was used to detect DEGs between BRCA bone metastatic cases and non-bone metastatic cases, followed by the construction of a PPI network among DEGs. The main module among the PPI network was then determined and pathway analysis on genes within the module was performed. Through performing Cox regression, Kaplan-Meier, nomogram, and ROC curve analyses using GSE175692 and GSE124647 datasets at the same time, the most significant prognostic biomarker was gradually filtered. Finally, important pathways associated with prognostic biomarkers were explored by GSEA analysis.Results: The 74 DEGs were detected between bone metastasis and non-bone metastasis groups. A total of 15 nodes were included in the main module among the whole PPI network and they mainly correlated with the IL-17 signaling pathway. We then performed Cox analysis on 15 genes using two datasets and only enrolled the genes with p < 0.05 in Cox analysis into the further analyses. Kaplan-Meier analyses using two datasets showed that the common biomarker AGR2 expression was related to the survival time of BRCA metastatic cases. Further, the nomogram determined the greatest contribution of AGR2 on the survival probability and the ROC curve revealed its optimal prognostic performance. More importantly, high expression of AGR2 prolonged the survival time of BRCA bone metastatic patients. These results all suggested the importance of AGR2 in metastatic BRCA. Finally, we performed the GSEA analysis and found that AGR2 was negatively related to IL-17 and NF-kβ signaling pathways.Conclusion: AGR2 was finally determined as the most important prognostic biomarker in BRCA bone metastasis, and it may play a vital role in cancer progression by regulating IL-17 and NF-kB signaling pathways