3,703 research outputs found
2-(4-Bromophenyl)-2-methylpropanamide
In the crystal of the title compound, C10H12BrNO, inversion dimers linked by pairs of N—H⋯O hydrogen bonds generate R
2
2(8) loops. Further N—H⋯O hydrogen bonds link the dimers into sheets propagating in (100)
Mapping and candidate-gene screening of the novel Turnip mosaic virus resistance gene retr02 in Chinese cabbage (Brassica rapa L.)
The extreme resistance to Turnip mosaic virus observed in the Chinese cabbage (Brassica rapa) line, BP8407, is monogenic and recessive. Bulked segregant analysis was carried out to identify simple sequence repeat and Indel markers linked to this recessive resistance gene, termed recessive Turnip mosaic virus resistance 02 (retr02). Mapping of PCR-specific Indel markers on 239 individuals of a BP8407 × Ji Zao Chun F 2 population, located this resistance gene to a 0.9-cM interval between two Indel markers (BrID10694 and BrID101309) and in scaffold000060 or scaffold000104 on chromosome A04 of the B. rapa genome. Eleven eukaryotic initiation factor 4E (eIF4E) and 14 eukaryotic initiation factor 4G (eIF4G) genes are predicted in the B. rapa genome. A candidate gene, Bra035393 on scaffold000104, was predicted within the mapped resistance locus. The gene encodes the eIF(iso)4E protein. Bra035393 was sequenced in BP8407 and Ji Zao Chun. A polymorphism (A/G) was found in exon 3 between BP8407 and Ji Zao Chun. This gene was analysed in four resistant and three susceptible lines. A correlation was observed between the amino acid substitution (Gly/Asp) in the eIF(iso)4E protein and resistance/susceptibility. eIF(iso)4E has been shown previously to interact with the TuMV genome-linked protein, VPg
miR-638 is a new biomarker for outcome prediction of non-small cell lung cancer patients receiving chemotherapy.
MicroRNAs (miRNAs), a class of small non-coding RNAs, mediate gene expression by either cleaving target mRNAs or inhibiting their translation. They have key roles in the tumorigenesis of several cancers, including non-small cell lung cancer (NSCLC). The aim of this study was to investigate the clinical significance of miR-638 in the evaluation of NSCLC patient prognosis in response to chemotherapy. First, we detected miR-638 expression levels in vitro in the culture supernatants of the NSCLC cell line SPC-A1 treated with cisplatin, as well as the apoptosis rates of SPC-A1. Second, serum miR-638 expression levels were detected in vivo by using nude mice xenograft models bearing SPC-A1 with and without cisplatin treatment. In the clinic, the serum miR-638 levels of 200 cases of NSCLC patients before and after chemotherapy were determined by quantitative real-time PCR, and the associations of clinicopathological features with miR-638 expression patterns after chemotherapy were analyzed. Our data helped in demonstrating that cisplatin induced apoptosis of the SPC-A1 cells in a dose- and time-dependent manner accompanied by increased miR-638 expression levels in the culture supernatants. In vivo data further revealed that cisplatin induced miR-638 upregulation in the serum derived from mice xenograft models, and in NSCLC patient sera, miR-638 expression patterns after chemotherapy significantly correlated with lymph node metastasis. Moreover, survival analyses revealed that patients who had increased miR-638 levels after chemotherapy showed significantly longer survival time than those who had decreased miR-638 levels. Our findings suggest that serum miR-638 levels are associated with the survival of NSCLC patients and may be considered a potential independent predictor for NSCLC prognosis
Time-resolved boson sampling with photons of different colors
Interference of multiple photons via a linear-optical network has profound
applications for quantum foundation, quantum metrology and quantum computation.
Particularly, a boson sampling experiment with a moderate number of photons
becomes intractable even for the most powerful classical computers, and will
lead to "quantum supremacy". Scaling up from small-scale experiments requires
highly indistinguishable single photons, which may be prohibited for many
physical systems. Here we experimentally demonstrate a time-resolved version of
boson sampling by using photons not overlapping in their frequency spectra from
three atomic-ensemble quantum memories. Time-resolved measurement enables us to
observe nonclassical multiphoton correlation landscapes. An average fidelity
over several interferometer configurations is measured to be 0.936(13), which
is mainly limited by high-order events. Symmetries in the landscapes are
identified to reflect symmetries of the optical network. Our work thus provides
a route towards quantum supremacy with distinguishable photons.Comment: 5 pages, 3 figures, 1 tabl
10-Ethyl-3-(5-methyl-1,3,4-oxadiazol-2-yl)-10H-phenothiazine
In the title compound, C17H15N3OS, the phenothiazine ring system is slightly bent, with a dihedral angle of 13.68 (7)° between the benzene rings. The dihedral angle between the oxadiazole ring and the adjacent benzene ring is 7.72 (7)°. In the crystal, a π–π interaction with a centroid–centroid distance of 3.752 (2) Å is observed between the benzene rings of neighbouring molecules
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