Isoscoparins R and S, two new <i>ent</i>-clerodane diterpenoids from <i>Isodon scoparius</i>

<p>Two new <i>ent</i>-clerodane diterpenoids, named isoscoparins R and S (<b>1</b> and <b>2</b>), were isolated from the aerial parts of <i>Isodon scoparius</i>. Their structures were characterized mainly by analyzing the NMR and HRESIMS data, and the relative configuration of compound <b>1</b> was determined by single-crystal X-ray diffraction. Compound <b>2</b> showed weak activity as an autophagic inhibitor.</p