DataSheet_1_Promising clinical outcome after body gamma knife radiotherapy for mediastinal follicular dendritic cell sarcoma with thoracic spine invasion and iliac metastasis: A case report and literature review.docx

BackgroundFollicular dendritic cell sarcoma (FDCS) is a rare type of intermediate grade tumor. Mediastinal FDCS with spinal invasion has not been well described. The treatment options include surgical resection and radiation therapy. The body gamma knife is a stereotactic body radiotherapy (SBRT) technology that is widely used in China. The pathological evaluation of a bone lesion after a body gamma knife procedure has not been reported. Here, we report a case of a patient with FDCS with thoracic spine invasion and iliac metastasis treated with surgery and body gamma knife.Case summaryA 36-year-old male patient was hospitalized at Zhongshan Hospital, Fudan University, due to a gradually aggravated pain on the lateral side of the left scapula for 6 months. Imaging examination showed neoplastic lesions on the left side of C7-T2 invading the vertebral body of T1, T2, and caput costae of the second rib and suspected metastasis in the left ilium. FDCS was diagnosed after performing a computed tomography (CT)-guided core needle biopsy, and the thoracic lesion was surgically resected. The body gamma knife was used as an adjuvant radiotherapy for the thoracic lesion and a primary therapy for the left ilium lesion. Iliac bone lesion resection was performed at Zhongshan Hospital, Fudan University, 10 weeks after RT. Compared with the biopsy report, the body gamma knife treatment resulted in a pathological complete response (PCR). The magnetic resonance imaging (MRI) examinations showed stable disease of the thoracic lesion after body gamma knife radiosurgery.ConclusionThis case report describes the treatment of mediastinal FDCS with thoracic spinal invasion and iliac metastasis. The promising outcome suggests that separation surgery is an effective treatment option for mediastinal FDCS with spinal column invasion. It also demonstrates the application prospects of the body gamma knife treatment in malignant lesions of the axial bones.</p

CHX chase analysis showed that treatment with ethanol and D3T delayed the degradation of Nrf2 protein in PC12 cells.

<p>Western blot was performed to analyze the level of Nrf2 protein in PC12 cells. Cell lysates were prepared from PC12 cells cultured in control medium (lane 1), treated with proteasome inhibitor MG132 (30 µM) for 3 hrs (lane 2), treated with MG132 for 3 hrs, followed by treatment for 2 hrs with CHX (an inhibitor of protein synthesis,100 µg/ml) alone (lane 3), or CHX along with either 200 mM ethanol (lane 4), 50 µM D3T (lane 5), or ethanol plus D3T (lane 6). Data are expressed as fold change over control and represent the mean ± SEM of three separate experiments. * <i>p<</i>0.05 <i>vs.</i> group treated with MG132 and CHX (lane 3).</p

Treatment with ethanol and D3T increased the level of Nrf2 protein in PC12 cells.

<p>Western blot was performed to analyze the level of Nrf2 protein in PC12 cells. Cell lysates were prepared from PC12 cells cultured in control medium (Control), treated with 200 mM ethanol (EtOH), treated with 50 µM D3T alone (D3T), or treated with both ethanol and D3T (EtOH+D3T). Data are expressed as fold change over control and represent the mean ± SEM of three separate experiments. * <i>p<</i>0.05 <i>vs.</i> control.</p

Flow cytometry of apoptotic PC12 cells with Annexin V-FITC showed that D3T treatment significantly prevents ethanol-induced apoptosis.

<p>Apoptosis was measured in PC12 cells cultured in control medium (Control), treated with 200 mM ethanol (EtOH), treated with 50 µM D3T alone (D3T), or treated with both ethanol and D3T (EtOH+D3T). Data are expressed as fold change over control and represent the Mean ± SEM of three separate experiments. *<i>p<</i>0.05 <i>vs.</i> control. #<i>p<</i>0.05 <i>vs.</i> EtOH.</p

Numerical Calculation Method of Apparent Contact Angles on Heterogeneous Double-Roughness Surfaces

Double-roughness surfaces can be used to mimic lotus surfaces. The apparent contact angles (ACAs) of droplets on these surfaces were first calculated by Herminghaus. Then Patankar utilized the pillar model to improve the Herminghaus approach and put forward the formulas for ACAs calculation of the homogeneous double-roughness surfaces where the dual-scale structures and the bases were the same wettable materials. In this paper, we propose a numerical calculation method of ACAs on the heterogeneous double-roughness surfaces where the dual-scale structures and the bases are made of different wettable materials. This numerical calculation method has successfully enhanced the Herminghaus approach. It is promising to become a novel design approach of heterogeneous superhydrophobic surfaces, which are frequently applied in technical fields of self-cleaning, anti-icing, antifogging, and enhancing condensation heat transfer

Electrode Surface Film Formation in Tris(ethylene glycol)-Substituted Trimethylsilane–Lithium Bis(oxalate)borate Electrolyte

One of the silicon-based electrolytes, tris(ethylene glycol)-substituted trimethylsilane (1NM3)–lithium bis(oxalate)borate (LiBOB), is studied as an electrolyte for the LiMn₂O₄ cathode and graphite anode cell. The solid electrolyte interface (SEI) characteristics and chemical components of both electrodes were investigated by X-ray photoelectron spectroscopy and X-ray diffraction. It was found that SEI components on the anode are similar to those using carbonate–LiBOB electrolyte, which consists of lithium oxalate, lithium borooxalate, and Li_<i>x</i>BO_<i>y</i>. Moreover, we demonstrated that 1NM3–LiPF₆ electrolyte, which lacks an SEI formation function, could not maintain the graphite structure during the electrochemical process. Therefore, it is evident that the 1NM3–LiBOB combination and its suitable SEI film formation capability are vital to the lithium ion battery with graphite as the anode

Numerical Study for a Large-Volume Droplet on the Dual-Rough Surface: Apparent Contact Angle, Contact Angle Hysteresis, and Transition Barrier

The profile, apparent contact angle (ACA), contact angle hysteresis (CAH), and wetting state transmission energy barrier (WSTEB) are important static and dynamic properties of a large-volume droplet on the hierarchical surface. Understanding them can provide us with important insights into functional surfaces and promote the application in corresponding areas. In this paper, we establish three theoretical models (models 1–3) and the corresponding numerical methods, which were obtained by the free energy minimization and the nonlinear optimization algorithm, to predict the profile, ACA, CAH, and WSTEB of a large-volume droplet on the horizontal regular dual-rough surface. In consideration of the gravity, the energy barrier on the contact circle, the dual heterogeneous structures and their roughness on the surface, the models are more universal and accurate than the previous models. It showed that the predictions of the models were in good agreement with the results from the experiment or literature. The models are promising to become novel design approaches of functional surfaces, which are frequently applied in microfluidic chips, water self-catchment system, and dropwise condensation heat transfer system

Query accuracy probability vs. detection time in Wireless.

<p>Query accuracy probability vs. detection time in Wireless.</p

An energy-efficient failure detector for vehicular cloud computing

<div><p>Failure detectors are one of the fundamental components for maintaining the high availability of vehicular cloud computing. In vehicular cloud computing, lots of RSUs are deployed along the road to improve the connectivity. Many of them are equipped with solar battery due to the unavailability or excess expense of wired electrical power. So it is important to reduce the battery consumption of RSU. However, the existing failure detection algorithms are not designed to save battery consumption RSU. To solve this problem, a new energy-efficient failure detector 2E-FD has been proposed specifically for vehicular cloud computing. 2E-FD does not only provide acceptable failure detection service, but also saves the battery consumption of RSU. Through the comparative experiments, the results show that our failure detector has better performance in terms of speed, accuracy and battery consumption.</p></div

Mistake rate vs. detection time in WAN.

<p>Mistake rate vs. detection time in WAN.</p