Investigating the topological structure of quenched lattice QCD with overlap fermions by using multi-probing approximation

The topological charge density and topological susceptibility are determined by multi-probing approximation using overlap fermions in quenched SU(3) gauge theory. Then we investigate the topological structure of the quenched QCD vacuum, and compare it with results from the all-scale topological density, the results are consistent. Random permuted topological charge density is used to check whether these structures represent underlying ordered properties. Pseudoscalar glueball mass is extracted from the two-point correlation function of the topological charge density. We study $3$ ensembles of different lattice spacing $a$ with the same lattice volume $16^{3}\times32$, the results are compatible with the results of all-scale topological charge density, and the topological structures revealed by multi-probing are much closer to all-scale topological charge density than that by eigenmode expansion.Comment: 12 pages,34 figure

Two variants on T2DM susceptible gene HHEX are associated with CRC risk in a Chinese population

Increasing amounts of evidence has demonstrated that T2DM (Type 2 Diabetes Mellitus) patients have increased susceptibility to CRC (colorectal cancer). As HHEX is a recognized susceptibility gene in T2DM, this work was focused on two SNPs in HHEX, rs1111875 and rs7923837, to study their association with CRC. T2DM patients without CRC (T2DM-only, n=300), T2DM with CRC (T2DM/CRC, n=135), cancer-free controls (Control, n=570), and CRC without T2DM (CRC-only, n=642) cases were enrolled. DNA samples were extracted from the peripheral blood leukocytes of the patients and sequenced by direct sequencing. The χ(2) test was used to compare categorical data. We found that in T2DM patients, rs1111875 but not the rs7923837 in HHEX gene was associated with the occurrence of CRC (p= 0.006). for rs1111875, TC/CC patients had an increased risk of CRC (p=0.019, OR=1.592, 95%CI=1.046-2.423). Moreover, our results also indicated that the two variants of HEEX gene could be risk factors for CRC in general population, independent on T2DM (p< 0.001 for rs1111875, p=0.001 for rs7923837). For rs1111875, increased risk of CRC was observed in TC or TC/CC than CC individuals (p<0.001, OR= 1.780, 95%CI= 1.385-2.287; p<0.001, OR= 1.695, 95%CI= 1.335-2.152). For rs7923837, increased CRC risk was observed in AG, GG, and AG/GG than AA individuals (p< 0.001, OR= 1.520, 95%CI= 1.200-1.924; p=0.036, OR= 1.739, 95%CI= 0.989-3.058; p< 0.001, OR= 1.540, 95%CI= 1.225-1.936). This finding highlights the potentially functional alteration with HHEX rs1111875 and rs7923837 polymorphisms may increase CRC susceptibility. Risk effects and the functional impact of these polymorphisms need further validation

Effect of dark matter on shadows and rings of a brane-world black hole illuminated by various accretions

In this paper, by taking the accretions into account, the observational shadows and rings casted by the Brane-world black hole are numerically investigated when the observer located at the cosmological horizon. The results here show that the radius $r_p$ of photon sphere increased with cosmological parameter $\alpha$ and dark matter parameter $\beta$, while the impact parameter $b_p$ decreased with $\alpha$ and increased with $\beta$. For the thin-disk accretion, it turns out that the total observed intensity are mainly composed of the direct emission, while lensing ring and photon ring only contribute a small contribution and a negligible contribution, respectively. And, we find that shadow and rings exhibit some different and interesting features when the disk located at different positions. For the static and infalling spherical accretions, it is obvious that the size of shadow is always the same for both accretions, which means that shadow is only related to the geometry of space time in this case. The luminosity of shadow and photon sphere are closely related to the Doppler effect and the emissivity per unit volume $j({\nu_e})$. In addition, the influence of dark matter and cosmological constant on observed intensity of shadows and rings are carefully emphasized throughout of this paper. Finally, we obtained the burring images of shadows and rings by using the nominal resolution of the Event Horizon Telescope, and studied the upper limits on the X-clod dark matter parameter $\beta$ with the aid of the data of the shadow of M87.Comment: 66figures, 4tables, 26pages,accepted by SCIENCE CHINA Physics, Mechanics & Astronomy,202

Linezolid and Rifampicin Combination to Combat cfr-Positive Multidrug-Resistant MRSA in Murine Models of Bacteremia and Skin and Skin Structure Infection.

Linezolid resistance mediated by the cfr gene in MRSA represents a global concern. We investigated relevant phenotype differences between cfr-positive and -negative MRSA that contribute to pathogenesis, and the efficacy of linezolid-based combination therapies in murine models of bacteremia and skin and skin structure infection (SSSI). As a group, cfr-positive MRSA exhibited significantly reduced susceptibilities to the host defense peptides tPMPs, human neutrophil peptide-1 (hNP-1), and cathelicidin LL-37 (P &lt; 0.01). In addition, increased binding to fibronectin (FN) and endothelial cells paralleled robust biofilm formation in cfr-positive vs. -negative MRSA. In vitro phenotypes of cfr-positive MRSA translated into poor outcomes of linezolid monotherapy in vivo in murine bacteremia and SSSI models. Importantly, rifampicin showed synergistic activity as a combinatorial partner with linezolid, and the EC50 of linezolid decreased 6-fold in the presence of rifampicin. Furthermore, this combination therapy displayed efficacy against cfr-positive MRSA at clinically relevant doses. Altogether, these data suggest that the use of linezolid in combination with rifampicin poses a viable therapeutic alternative for bacteremia and SSSI caused by cfr-positive multidrug resistant MRSA

Effect of temperature on microstructure and deformation mechanism of Fe-30Mn-3Si-4Al TWIP steel at strain rate of 700 s-1

As twinning-induced plasticity (TWIP) steel is one potential material for shaped charge liner due to the combination of high strength and high plasticity, deformation mechanism at high strain rate and high temperature is required to study. Compression experiments of Fe-30Mn-3Si-4Al TWIP steel were conducted using a Gleeble-1500 thermal simulation machine and a split-Hopkinson pressure bar (SHPB) between 298 and 1073 K at strain rates of 10-3 and 700 s-1, respectively. Microstructures were observed using optical microscopy (OM) and transmission electron microscopy (TEM). Results show that flow stress and densities of deformation twins and dislocations decrease with increasing deformation temperature at strain rates of 10-3 and 700 s-1. The stack fault energy (SFE) values (Γ) of Fe-30Mn-3Si-4Al TWIP steel at different temperatures were calculated using thermodynamic data. Based on corresponding microstructures, it can be inferred that at 700 s-1, twinning is the main deformation mechanism at 298-573 K for 30 mJ/m2≤Γ≤63 mJ/m, while dislocation gliding is the main deformation mechanism above 1073 K for Γ≥ 145 mJ/m2. In addition, with increasing strain rate from 10-3 to 700 s-1, the SFE range of twinning is enlarged and the SEF value of twinning becomes higher