Total Syntheses of Highly Oxidized <i>ent</i>-Kaurenoids Pharicin A, Pharicinin B, 7‑<i>O</i>‑Acetylpseurata C, and Pseurata C: A [5+2] Cascade Approach

The unprecedented oxidative dearomatization-induced [5+2] cycloaddition/pinacol-type 1,2-acyl migration cascade efficiently generates a quaternary carbon center and assembles the highly oxygenated bicyclo[3.2.1]­octane framework of <i>ent</i>-kaurene diterpenoids. By incorporation of the subsequent retro-aldol/aldol process and singlet oxygen ene reaction, this concise and convergent approach has enabled the first asymmetric total syntheses of pharicin A, pharicinin B, 7-<i>O</i>-acetylpseurata C, and pseurata C

Additional file 1: of Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression

Figure S1. PI3K/Akt/mTOR pathway inhibition modulates the proliferation and invasion of SW620 cells. (a) SW620 cells were treated LY294002 or siSNHG7. The main molecular expression of PI3K/Akt/mTOR pathway was detected by western blot. (b) LY294002 or siSNHG7 treatment also alleviated proliferation and invsion of SW620 cells. (TIF 2009 kb