Ambidextrous Strategy and Firm Performance: The Moderating Effects of Organizational Slack and Organizational Life Cycle

The relationship between ambidexterity and firm performance holds a prominent place in the literature. However, studies that examine the conditions under which ambidexterity leads to success are relatively scarce. Based on a sample of 226 firms in China, this study examines the moderating effects of organizational slack and organizational life cycle on the relationship between balance dimension of ambidexterity and combined dimension of ambidexterity and firm performance. The empirical results reveal that pursuing a high level of combined dimension of organizational ambidexterity is only beneficial to firms with a high level of organizational slack or firms in maturity stage, while pursuing a high level of balance dimension of organizational ambidexterity is only beneficial to firms in growth stage, but not to firms in maturity stage

Two-dimensional Fast Surface Imaging Using a Handheld Optical Device: In Vitro and In Vivo Fluorescence Studies

Near-infrared (NIR) optical imaging is a noninvasive and nonionizing modality that is emerging as a diagnostic tool for breast cancer. The handheld optical devices developed to date using the NIR technology are predominantly developed for spectroscopic applications. A novel handheld probe–based optical imaging device has been recently developed toward area imaging and tomography applications. The three-dimensional (3D) tomographic imaging capabilities of the device have been demonstrated from previous fluorescence studies on tissue phantoms. In the current work, fluorescence imaging studies are performed on tissue phantoms, in vitro, and in vivo tissue models to demonstrate the fast two-dimensional (2D) surface imaging capabilities of this flexible handheld-based optical imaging device, toward clinical breast imaging studies. Preliminary experiments were performed using target( s) of varying volume (0.23 and 0.45 cm3) and depth (1-2 cm), using indocyanine green as the fluorescence contrast agent in liquid phantom, in vitro, and in vivo tissue models. The feasibility of fast 2D surface imaging (∼5 seconds) over large surface areas of 36 cm2 was demonstrated from various tissue models. The surface images could differentiate the target(s) from the background, allowing a rough estimate of the target’s location before extensive 3D tomographic analysis (future studies)

The moderating effects of slack on the relationship between ambidextrous strategy and performance: evidence from high-tech firms in China

The purpose of this study is to examine the impacts of ambidexterity of exploration/exploitation on long-term performance and the moderating effects of slack resources. The methodology adopted is panel data analysis of a sample dataset of 125 high technology firms in China. The finding of this study shows that a moderating role of organizational slack between ambidexterity and long-term performance is strongly supported. The research and practical implications of this paper are: (1) Exploration and exploitation can be mutually enhancing instead of being fundamentally contradictory; (2) Slack resources moderate the relationship between ambidexterity and performance. The originality and value of the paper is that it is one of the earliest studies that empirically examine the moderating effects of slack resources on ambidexterity-performance relationship

A Nationwide Study of Maternal Exposure To Ambient Ozone and Term Birth Weight In the United States

Background: Maternal exposure to ozone (O3) may cause systemic inflammation and oxidative stress and contribute to fetal growth restriction. We sought to estimate the association between maternal exposure to O3 and term birth weight and term small for gestational age (SGA) in the United States (US). Methods: We conducted a nationwide study including 2,179,040 live term singleton births that occurred across 453 populous counties in the contiguous US in 2002. Daily county-level concentrations of O3 data were estimated using a Bayesian fusion model. We used linear regression to estimate the association between O3 exposure and term birth weight and logistic regression to estimate the association between O3 exposure and term SGA during each trimester of the pregnancy and the entire pregnancy after adjusting for maternal characteristics, infant sex, season of conception, ambient temperature, county poverty rate, and census region. We additionally used distributed lag models to identify the critical exposure windows by estimating the monthly and weekly associations. Results: A 10 parts per billion (ppb) increase in O3 over the entire pregnancy was associated with a lower term birth weight (-7.6 g; 95 % CI: −8.8 g, −6.4 g) and increased risk of SGA (odds ratio = 1.030; 95 % CI: 1.020, 1.040). The identified critical exposure windows were the 13th- 25th and 32nd −37th gestational weeks for term birth weight and 13th- 25th for term SGA. We found the association was more pronounced among mothers who were non-Hispanic Black, unmarried, or had lower education level. Conclusions: Among US singleton term births, maternal exposure to O3 was associated with lower rates of fetal growth, and the 13th- 25th gestational weeks were the identified critical exposure windows

Evidences for pressure-induced two-phase superconductivity and mixed structures of NiTe₂ and NiTe in type-II Dirac semimetal NiTe_(2-x) (x = 0.38 ± 0.09) single crystals

Bulk NiTe₂ is a type-II Dirac semimetal with non-trivial Berry phases associated with the Dirac fermions. Theory suggests that monolayer NiTe₂ is a two-gap superconductor, whereas experimental investigation of bulk NiTe_(1.98) for pressures (P) up to 71.2 GPa do not reveal any superconductivity. Here we report experimental evidences for pressure-induced two-phase superconductivity as well as mixed structures of NiTe₂ and NiTe in Te-deficient NiTe_(2-x) (x = 0.38±0.09) single crystals. Hole-dominant multi-band superconductivity with the P3M1 hexagonal-symmetry structure of NiTe₂ appears at P ≥ 0.5 GPa, whereas electron-dominant single-band superconductivity with the P2/m monoclinic-symmetry structure of NiTe emerges at 14.5 GPa < P < 18.4 GPa. The coexistence of hexagonal and monoclinic structures and two-phase superconductivity is accompanied by a zero Hall coefficient up to ∼ 40 GPa, and the second superconducting phase prevails above 40 GPa, reaching a maximum T_c = 7.8 K and persisting up to 52.8 GPa. Our findings suggest the critical role of Te-vacancies in the occurrence of superconductivity and potentially nontrivial topological properties in NiTe_(2-x)

SMYD5 Is a Ribosomal Methyltransferase That Catalyzes RPL40 Lysine Methylation To Enhance Translation Output and Promote Hepatocellular Carcinoma

While lysine methylation is well-known for regulating gene expression transcriptionally, its implications in translation have been largely uncharted. Trimethylation at lysine 22 (K22me3) on RPL40, a core ribosomal protein located in the GTPase activation center, was first reported 27 years ago. Yet, its methyltransferase and role in translation remain unexplored. Here, we report that SMYD5 has robust in vitro activity toward RPL40 K22 and primarily catalyzes RPL40 K22me3 in cells. The loss of SMYD5 and RPL40 K22me3 leads to reduced translation output and disturbed elongation as evidenced by increased ribosome collisions. SMYD5 and RPL40 K22me3 are upregulated in hepatocellular carcinoma (HCC) and negatively correlated with patient prognosis. Depleting SMYD5 renders HCC cells hypersensitive to mTOR inhibition in both 2D and 3D cultures. Additionally, the loss of SMYD5 markedly inhibits HCC development and growth in both genetically engineered mouse and patient-derived xenograft (PDX) models, with the inhibitory effect in the PDX model further enhanced by concurrent mTOR suppression. Our findings reveal a novel role of the SMYD5 and RPL40 K22me3 axis in translation elongation and highlight the therapeutic potential of targeting SMYD5 in HCC, particularly with concurrent mTOR inhibition. This work also conceptually broadens the understanding of lysine methylation, extending its significance from transcriptional regulation to translational control

Enzymatic processing of protein-based fibers

Wool and silk are major protein fiber materials used by the textile industry. Fiber protein structure-function relationships are briefly described here, and the major enzymatic processing routes for textiles and other novel applications are deeply reviewed. Fiber biomodification is described here with various classes of enzymes such as protease, transglutaminase, tyrosinase, and laccase. It is expected that the reader will get a perspective on the research done as a basis for new applications in other areas such as cosmetics and pharma.This work was financially supported by the National Natural Science Foundation of China (21274055,51373071, 31201134 and 31470509), the Program for New Century Excellent Talents in University (NCET-12-0883), the Program for Changjiang Scholars and Innovative Research Team in University (IRT1135), the Jiangsu Provincial Natural Science Foundation of China (BK2012112), and the Fundamental Research Funds for the Central Universities (JUSRP51312B)

Fluorescence-enhanced optical imaging on three-dimensional phantoms using a hand-held probe based frequency-domain intensified charge coupled device (ICCD) optical imager

Fluorescence-enhanced optical imaging is an emerging non-invasive and non-ionizing modality towards breast cancer diagnosis. Various optical imaging systems are currently available, although most of them are limited by bulky instrumentation, or their inability to flexibly image different tissue volumes and shapes. Hand-held based optical imaging systems are a recent development for its improved portability, but are currently limited only to surface mapping. Herein, a novel optical imager, consisting primarily of a hand-held probe and a gain-modulated intensified charge coupled device (ICCD) detector, is developed towards both surface and tomographic breast imaging. The unique features of this hand-held probe based optical imager are its ability to; (i) image large tissue areas (5×10 sq. cm) in a single scan, (ii) reduce overall imaging time using a unique measurement geometry, and (iii) perform tomographic imaging for tumor three-dimensional (3-D) localization. Frequency-domain based experimental phantom studies have been performed on slab geometries (650 ml) under different target depths (1-2.5 cm), target volumes (0.45, 0.23 and 0.10 cc), fluorescence absorption contrast ratios (1:0, 1000:1 to 5:1), and number of targets (up to 3), using Indocyanine Green (ICG) as fluorescence contrast agents. An approximate extended Kalman filter based inverse algorithm has been adapted towards 3-D tomographic reconstructions. Single fluorescence target(s) was reconstructed when located: (i) up to 2.5 cm deep (at 1:0 contrast ratio) and 1.5 cm deep (up to 10:1 contrast ratio) for 0.45 cc-target; and (ii) 1.5 cm deep for target as small as 0.10 cc at 1:0 contrast ratio. In the case of multiple targets, two targets as close as 0.7 cm were tomographically resolved when located 1.5 cm deep. It was observed that performing multi-projection (here dual) based tomographic imaging using a priori target information from surface images, improved the target depth recovery over using single projection based imaging. From a total of 98 experimental phantom studies, the sensitivity and specificity of the imager was estimated as 81-86% and 43-50%, respectively. With 3-D tomographic imaging successfully demonstrated for the first time using a hand-held based optical imager, the clinical translation of this technology is promising upon further experimental validation from in-vitro and in-vivo studies

Moving Forward towards Sustainability: Contributions of the Living Building Challenge to Triple Bottom Line Reporting

Thesis (Master's)--University of Washington, 2014Sustainability-related reporting by companies and organizations has been developed with the growth of the notion of sustainability since the 1970s. More recently, Triple Bottom Line (TBL) reporting, one form of sustainability-related reporting which looks at a company's environmental, social and economic aspects, has been widely researched and discussed. The G4 Sustainability Reporting Framework (Framework) put forward by the Global Reporting Initiative, is the most recognized and practiced TBL reporting structure. More and more companies worldwide, especially big multinational firms such as the Fortune Global 500, do TBL reporting under the Framework, aiming to keep on track with their vision and mission, to assist decision-making, to promote their public image, to share information with stakeholders, and to gain positive economic benefits. However, among these sustainability pioneer companies, no construction or real estate companies are seen. The real estate and construction sectors, together with the many fields and industries associated with them, make up one of the larger components of the global economy (Plunkett Research 2014). As of 2012, the U.S. Bureau of Labor estimated that 5.64 million Americans were employed in the construction industry. About $885.1 billion in new American construction was put in place during 2012, according to the U.S. Bureau of the Census (Plunkett Research 2014). As the construction and real estate sector also has a high impact on climate change, natural resources and natural ecosystems, if the sector notices the benefits of doing sustainability reporting, it will push forward their sustainability agenda. The construction and real estate sector puts sustainability into practice by means of reaching standards such as building and planning codes, Leadership in Energy & Environmental Design certification and affordable housing. The Living Building Challenge (LBC) is the "greenest" one among them, and it concerns all three bottom lines of TBL reporting. This thesis aims to answer the question: How does the LBC Prepare Developers for TBL Reporting? If we can bring the LBC and the Framework together, the combination will facilitate TBL reporting of the construction and real estate sector. The paper concludes that the LBC has excellent performance on the environmental aspect, the data of which are appropriate for environmental performance reporting. The LBC includes less data about economic and social performance, but assists TBL reporting indirectly. The LBC helps to ensure reporting contents and quality as well. Apart from criteria listed on the Framework, the LBC also identifies criteria specific for the construction and real estate sector, such as beauty of the project and car free living, which may add value on a building projects' sustainability performance. The research results suggest that developers or property managers who construct or manage buildings meeting the LBC to think about preparing TBL reporting. The reason is that the LBC data collected from the buildings are adequate to start TBL reporting and environmental data are quite resourceful and detailed. Further, the research findings are helpful to equip other interest groups, such as designers, planners and policymakers, to design and construct more sustainable buildings and communities