4 research outputs found
Nickel-Doped Ultrathin K‑Birnessite Manganese Oxide Nanosheet As Pseudocapacitor Electrode with Excellent Cycling Stability for High-Power Pesudocapacitors
We herein report a kind of nickel-doped
ultrathin δ-MnO<sub>2</sub> nanosheets prepared using a facile
chemical bath deposition method. The obtained δ-MnO<sub>2</sub> materials have 2D ultrathin nanosheet structures with a few atomic
layers. Electrochemical measurements indicate that an appropriate
amount of nickel doping can remarkably improve the specific capacitance
of the δ-MnO<sub>2</sub> and that 1.0 mol % nickel-doped δ-MnO<sub>2</sub> nanosheets display the best specific capacitance of 337.9
F g<sup>–1</sup> at 1 A g<sup>–1</sup>. The specific
capacitance can maintain at 158 F g<sup>–1</sup> even as the
current density increases to 20 A g<sup>–1</sup>, demonstrating
that the electrode material possesses good rate performance. In addition,
the discharge capacity fading from 160.9 to 158.8 F g<sup>–1</sup> is slight after 4000 cycles, and the corresponding capacitance retention
is as high as 98.6%. The good rate capacity and stability of the δ-MnO<sub>2</sub> nanosheets can be attributed to the ultrathin structure of
a few atomic layers which provides large surface areas and lots of
reactive active sites. Moreover, the appropriate amount of nickel
ion doping at atomic level improves the conductivity of the δ-MnO<sub>2</sub> material
The electrocatalytic activity of pomelo peel-derived nitrogen-doped carbon material for oxygen reduction reaction
Exploring the non-precious metal catalysts of oxygen reduction reaction (ORR) becomes the key to promote the industrialization of new energy devices such as fuel cells and metal-air batteries because of the sluggish kinetics of ORR. Three-dimensional N-doped carbon (NC-900) material was obtained using the high-temperature pyrolysis of pomelo peel waste. The prepared NC-900 catalyst possesses an ultra-high specific surface area of 1631.3 m2·g−1, high content of 57.7 ± 0.9% pyrrolic-N, and three-dimensional porous structure. As the ORR catalyst, NC-900 has a onset potential of 0.992 V and half-wave potential of 0.859 V, comparable to 0.988 and 0.872 V of Pt/C. The typical 4-electron pathway of ORR process is occupied by the surface of NC-900. The ORR catalytic activity of NC-900 was almost unaffected by methanol. After 8 h of continuous operation, the reduction current on the surface of NC-900 was decreased only 2.7% of the initial current. Based on these outstanding ORR performances, the pomelo peel-derived NC-900 can serve as a strong competitor for the substitute of Pt/C to promote the potential industrialization of new energy devices.</p
DataSheet_1_Integrating single-cell RNA sequencing and prognostic model revealed the carcinogenicity and clinical significance of FAM83D in ovarian cancer.docx
BackgroundOvarian cancer (OC) is a fatal gynecological tumor with high mortality and poor prognosis. Yet, its molecular mechanism is still not fully explored, and early prognostic markers are still missing. In this study, we assessed carcinogenicity and clinical significance of family with sequence similarity 83 member D (FAM83D) in ovarian cancer by integrating single-cell RNA sequencing (scRNA-seq) and a prognostic model.MethodsA 10x scRNA-seq analysis was performed on cells from normal ovary and high-grade serous ovarian cancer (HGSOC) tissue. The prognostic model was constructed by Lasso-Cox regression analysis. The biological function of FAM83D on cell growth, invasion, migration, and drug sensitivity was examined in vitro in OC cell lines. Luciferase reporter assay was performed for binding analysis between FAM83D and microRNA-138-5p (miR-138-5p).ResultsOur integrative analysis identified a subset of malignant epithelial cells (C1) with epithelial-mesenchymal transition (EMT) and potential hyperproliferation gene signature. A FAM83D+ malignant epithelial subcluster (FAM83D+ MEC) was associated with cell cycle regulation, apoptosis, DNA repair, and EMT activation. FAM83D resulted as a viable prognostic marker in a prognostic model that efficiently predict the overall survival of OC patients. FAM83D downregulation in SKOV3 and A2780 cells increased cisplatin sensitivity, reducing OC cell proliferation, migration, and invasion. MiR-138-5p was identified to regulate FAM83D’s carcinogenic effect in OC cells.ConclusionsOur findings highlight the importance of miR-138 -5p/FAM83D/EMT signaling and may provide new insights into therapeutic strategies for OC.</p
A Robust Pyro-phototronic Route to Markedly Enhanced Photocatalytic Disinfection
Photocatalysis offers a direct, yet robust, approach
to eradicate
pathogenic bacteria. However, the practical implementation of photocatalytic
disinfection faces a significant challenge due to low-efficiency
photogenerated carrier separation and transfer. Here, we present an
effective approach to improve photocatalytic disinfection performance
by exploiting the pyro-phototronic effect through a synergistic combination
of pyroelectric properties and photocatalytic processes. A set of
comprehensive studies reveals that the temperature fluctuation-induced
pyroelectric field promotes photoexcited carrier separation and transfer
and thus facilitates the generation of reactive oxygen species and
ultimately enhances photocatalytic disinfection performance. It is
worth highlighting that the constructed film demonstrated an exceptional
antibacterial efficiency exceeding 95% against pathogenic bacteria
under temperature fluctuations and light irradiation. Moreover, the
versatile modulation role of the pyro-phototronic effect in boosting
photocatalytic disinfection was corroborated. This work paves the
way for improving photocatalytic disinfection efficiency by harnessing
the synergistic potential of various inherent material properties