Nickel-Doped Ultrathin K‑Birnessite Manganese Oxide Nanosheet As Pseudocapacitor Electrode with Excellent Cycling Stability for High-Power Pesudocapacitors

We herein report a kind of nickel-doped ultrathin δ-MnO₂ nanosheets prepared using a facile chemical bath deposition method. The obtained δ-MnO₂ materials have 2D ultrathin nanosheet structures with a few atomic layers. Electrochemical measurements indicate that an appropriate amount of nickel doping can remarkably improve the specific capacitance of the δ-MnO₂ and that 1.0 mol % nickel-doped δ-MnO₂ nanosheets display the best specific capacitance of 337.9 F g^–1 at 1 A g^–1. The specific capacitance can maintain at 158 F g^–1 even as the current density increases to 20 A g^–1, demonstrating that the electrode material possesses good rate performance. In addition, the discharge capacity fading from 160.9 to 158.8 F g^–1 is slight after 4000 cycles, and the corresponding capacitance retention is as high as 98.6%. The good rate capacity and stability of the δ-MnO₂ nanosheets can be attributed to the ultrathin structure of a few atomic layers which provides large surface areas and lots of reactive active sites. Moreover, the appropriate amount of nickel ion doping at atomic level improves the conductivity of the δ-MnO₂ material

The electrocatalytic activity of pomelo peel-derived nitrogen-doped carbon material for oxygen reduction reaction

Exploring the non-precious metal catalysts of oxygen reduction reaction (ORR) becomes the key to promote the industrialization of new energy devices such as fuel cells and metal-air batteries because of the sluggish kinetics of ORR. Three-dimensional N-doped carbon (NC-900) material was obtained using the high-temperature pyrolysis of pomelo peel waste. The prepared NC-900 catalyst possesses an ultra-high specific surface area of 1631.3 m2·g−1, high content of 57.7 ± 0.9% pyrrolic-N, and three-dimensional porous structure. As the ORR catalyst, NC-900 has a onset potential of 0.992 V and half-wave potential of 0.859 V, comparable to 0.988 and 0.872 V of Pt/C. The typical 4-electron pathway of ORR process is occupied by the surface of NC-900. The ORR catalytic activity of NC-900 was almost unaffected by methanol. After 8 h of continuous operation, the reduction current on the surface of NC-900 was decreased only 2.7% of the initial current. Based on these outstanding ORR performances, the pomelo peel-derived NC-900 can serve as a strong competitor for the substitute of Pt/C to promote the potential industrialization of new energy devices.</p

DataSheet_1_Integrating single-cell RNA sequencing and prognostic model revealed the carcinogenicity and clinical significance of FAM83D in ovarian cancer.docx

BackgroundOvarian cancer (OC) is a fatal gynecological tumor with high mortality and poor prognosis. Yet, its molecular mechanism is still not fully explored, and early prognostic markers are still missing. In this study, we assessed carcinogenicity and clinical significance of family with sequence similarity 83 member D (FAM83D) in ovarian cancer by integrating single-cell RNA sequencing (scRNA-seq) and a prognostic model.MethodsA 10x scRNA-seq analysis was performed on cells from normal ovary and high-grade serous ovarian cancer (HGSOC) tissue. The prognostic model was constructed by Lasso-Cox regression analysis. The biological function of FAM83D on cell growth, invasion, migration, and drug sensitivity was examined in vitro in OC cell lines. Luciferase reporter assay was performed for binding analysis between FAM83D and microRNA-138-5p (miR-138-5p).ResultsOur integrative analysis identified a subset of malignant epithelial cells (C1) with epithelial-mesenchymal transition (EMT) and potential hyperproliferation gene signature. A FAM83D+ malignant epithelial subcluster (FAM83D+ MEC) was associated with cell cycle regulation, apoptosis, DNA repair, and EMT activation. FAM83D resulted as a viable prognostic marker in a prognostic model that efficiently predict the overall survival of OC patients. FAM83D downregulation in SKOV3 and A2780 cells increased cisplatin sensitivity, reducing OC cell proliferation, migration, and invasion. MiR-138-5p was identified to regulate FAM83D’s carcinogenic effect in OC cells.ConclusionsOur findings highlight the importance of miR-138 -5p/FAM83D/EMT signaling and may provide new insights into therapeutic strategies for OC.</p

A Robust Pyro-phototronic Route to Markedly Enhanced Photocatalytic Disinfection

Photocatalysis offers a direct, yet robust, approach to eradicate pathogenic bacteria. However, the practical implementation of photocatalytic disinfection faces a significant challenge due to low-efficiency photogenerated carrier separation and transfer. Here, we present an effective approach to improve photocatalytic disinfection performance by exploiting the pyro-phototronic effect through a synergistic combination of pyroelectric properties and photocatalytic processes. A set of comprehensive studies reveals that the temperature fluctuation-induced pyroelectric field promotes photoexcited carrier separation and transfer and thus facilitates the generation of reactive oxygen species and ultimately enhances photocatalytic disinfection performance. It is worth highlighting that the constructed film demonstrated an exceptional antibacterial efficiency exceeding 95% against pathogenic bacteria under temperature fluctuations and light irradiation. Moreover, the versatile modulation role of the pyro-phototronic effect in boosting photocatalytic disinfection was corroborated. This work paves the way for improving photocatalytic disinfection efficiency by harnessing the synergistic potential of various inherent material properties