Expression of HSP10 and c-PARP proteins in astrocytoma was detected by immunohistochemistry.

<p>1-A, B: Positive expression of HSP10 was located in the cytoplasm of astrocytoma cells (high expression) and non-tumor control brain tissues (low expression) (20x, IHC, DAB staining). 1-C, D: Positive staining of c-PARP (arrows) was identified in the nucleus of astrocytoma cells (low expression: low apoptotic indices, AIs) and in the neurons of non-tumor control brain tissues (high expression: high AIs) (20x, IHC, DAB staining).</p

Kaplan-Meier curves according to expression of HSP10 and c-PARP proteins and common expression of two proteins divided into high and low expression.

<p>A: High expression of HSP10 was significantly correlated to poor prognosis of astrocytoma patients (P = 0.001, two sided). B: High expression of c-PARP did not significantly relate with survival of astrocytoma patients (<i>P</i> = 0.650, two sided). C: Astrocytoma patients with high expression of HSP10 and low expression of c-PARP had significantly short survival times (<i>P</i> < 0.019, two sided). D: Astrocytoma patients with high pathologic grades were evidently poor overall survival (<i>P</i>< 0.001, two sided).</p

Association between expression of HSP10 and c-PARP proteins and astrocytoma clinical pathological features (n = 103).

<p>Association between expression of HSP10 and c-PARP proteins and astrocytoma clinical pathological features (n = 103).</p

The pairwise association between expression of HSP10 and c-PARP proteins in the 103 cases of astrocytoma.

<p>The pairwise association between expression of HSP10 and c-PARP proteins in the 103 cases of astrocytoma.</p

Expression of HSP10 and c-PARP proteins in astrocytoma compared to non-tumor control brain tissues.

<p>Results showed that there were significant differences between the groups which were statistically evaluated by chi-square test (<i>P</i> < 0.05).</p

Summary of multivariate analysis of Cox proportional hazard regression for overall survival in 103 cases of astrocytoma.

<p>Summary of multivariate analysis of Cox proportional hazard regression for overall survival in 103 cases of astrocytoma.</p

The pairwise association between expression of p-Mnk1 and p-eIF4E protein in the 272 cases of NPC.

<p>The pairwise association between expression of p-Mnk1 and p-eIF4E protein in the 272 cases of NPC.</p

Kaplan-Meier overall survival curves of NPC patients with expression of p-Mnk1 and p-eIF4E protein and different clinicopathological characteristics.

<p>Kaplan-Meier analysis to plot the survival curve of all 272 NPC patients with expression of p-Mnk1 and p-eIF4E and different clinicopathological characteristics and statistical significance was assessed using the log-rank test. Fig. 3A. Kaplan-Meier curves showed worse overall survival for p-Mnk1–positive patients compared with p-Mnk1–negative patients (P<0.001, two sided). Fig. 3B. Kaplan-Meier curves showed worse survival for p-eIF4E–positive patients compared with p-eIF4E–negative patients (P = 0.004, two sided). Fig. 3C. NPC patients with clinical stage III and IV were significantly related to poor prognosis compared to those patients with clinical stage I and II (P = 0.003, two sided). Fig. 3D. NPC patients with lymph node metastasis were significantly related to poor prognosis compared to those patients without lymph node metastasis (P<0.001, two sided). Fig. 3E NPC patients with combination chemotherapy and radiotherapy were significantly related to good prognosis compared to patients with chemotherapy and radiotherapy alone (P = 0.006, two sided). Fig. 3F. Histological types of NPC patients were no significantly related to their prognosis (P>0.05, two sided).</p

Expression of Flot-2 and EGFR proteins in lung SCC and lung ADC compared to the control of non-cancerous lung tissues.

<p>Results showed that there were significant differences between the groups which were statistically evaluated by chi-square test.</p

Expression of EGFR protein in lung SCC cells, lung ADC cells and the control of non-cancerous lung tissue were detected by IHC using specific antibody as described in the section of materials and methods.

<p>Strong positive staining of EGFR protein was found in cell membranes and cytoplasm of lung SCC and lung ADC cells (Fig 2A and 2B, 20×, IHC, DAB staining). Negative staining of EGFR was showed in non-cancerous lung tissue (Fig 2C, 20×, IHC, DAB staining). Negative control showed no EGFR staining in the lung SCC cells (Fig 2D, 20×, IHC, DAB staining).</p