THE LOCAL BIOMECHANICAL ANALYSIS OF LOWER LIMB ON COUNTER-MOVEMENT JUMP BETWEEN BAREFOOT AND SHOD PEOPLE WITH DIFFERENT FOOT MORPHOLOGY

The aim of this study was to explore the kinematic variations in knee and ankle joints and the ground reaction force between habitually barefoot (HBM) and shod males (HSM) during countermovement jump. Twenty-eight males (14 HBM,14 HSM) participated in this experiment. An 8-camera Vicon motion system was used to collect the kinematic data of knee and ankle joints from 3 dimensions and the force plate was used to collect the ground reaction force in take-off phase. Results in take-off phase showed that HSM produced two peak forces to take off and showed significantly greater knee ROM in sagittal plane, as well as greater ankle inversion and external rotation. In conclusion, the foot morphological differences can result in the different influence on jump performance. The relevant practioner should pay close attention to the effect of foot morphology on jump in training

Electrical transport and magnetic properties of the triangular-lattice compound Zr2_2NiP2_2

We report the first investigation of the electrical and magnetic properties of the triangular-lattice compound Zr$_2$NiP$_2$ (space group $P$6$_3$/$mmc$). The temperature evolution of electrical resistivity follows the Bloch-Gr\"uneisen-Mott law, and exhibits a typically metallic behavior. No transition is visible by both electrical and magnetic property measurements, and nearly no magnetization is detected ($M_0$ $<$ 0.002$\mu_\mathrm{B}$/Ni) down to 1.8 K up to 7 T. The metallic and nonmagnetic characters are well understood by the first-principles calculations for Zr$_2$NiP$_2$.Comment: 16 pages, 4 figure

Production of Glycopeptide Derivatives for Exploring Substrate Specificity of Human OGA Toward Sugar Moiety.

O-GlcNAcase (OGA) is the only enzyme responsible for removing N-acetyl glucosamine (GlcNAc) attached to serine and threonine residues on proteins. This enzyme plays a key role in O-GlcNAc metabolism. However, the structural features of the sugar moiety recognized by human OGA (hOGA) remain unclear. In this study, a set of glycopeptides with modifications on the GlcNAc residue, were prepared in a recombinant full-length human OGT-catalyzed reaction, using chemoenzymatically synthesized UDP-GlcNAc derivatives. The resulting glycopeptides were used to evaluate the substrate specificity of hOGA toward the sugar moiety. This study will provide insights into the exploration of probes for O-GlcNAc modification, as well as a better understanding of the roles of O-GlcNAc in cellular physiology

Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Uses the VraSR Regulatory System to Modulate Autophagy for Increased Intracellular Survival in Macrophage-Like Cell Line RAW264.7

The VraSR two-component system is a vancomycin resistance-associated sensor/regulator that is upregulated in vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous VISA (hVISA) strains. VISA/hVISA show reduced susceptibility to vancomycin and an increased ability to evade host immune responses, resulting in enhanced clinical persistence. However, the underlying mechanism remains unclear. Recent studies have reported that S. aureus strains have developed some strategies to survive within the host cell by using autophagy processes. In this study, we confirmed that clinical isolates with high vraR expression showed increased survival in murine macrophage-like RAW264.7 cells. We constructed isogenic vraSR deletion strain Mu3ΔvraSR and vraSR-complemented strain Mu3ΔvraSR-C to ascertain whether S. aureus uses the VraSR system to modulate autophagy for increasing intracellular survival in RAW264.7. Overall, the survival of Mu3ΔvraSR in RAW264.7 cells was reduced at all infection time points compared with that of the Mu3 wild-type strain. Mu3ΔvraSR-infected RAW264.7 cells also showed decreased transcription of autophagy-related genes Becn1 and Atg5, decreased LC3-II turnover and increased p62 degradation, and fewer visible punctate LC3 structures. In addition, we found that inhibition of autophagic flux significantly increased the survival of Mu3ΔvraSR in RAW264.7 cells. Together, these results demonstrate that S. aureus uses the VraSR system to modulate host-cell autophagy processes for increasing its own survival within macrophages. Our study provides novel insights into the impact of VraSR on bacterial infection and will help to further elucidate the relationship between bacteria and the host immune response. Moreover, understanding the autophagic pathway in vraSR associated immunity has potentially important implications for preventing or treating VISA/hVISA infection

s-LWSR: Super Lightweight Super-Resolution Network

Deep learning (DL) architectures for superresolution (SR) normally contain tremendous parameters, which has been regarded as the crucial advantage for obtaining satisfying performance. However, with the widespread use of mobile phones for taking and retouching photos, this character greatly hampers the deployment of DL-SR models on the mobile devices. To address this problem, in this paper, we propose a super lightweight SR network: s-LWSR. There are mainly three contributions in our work. Firstly, in order to efficiently abstract features from the low resolution image, we build an information pool to mix multi-level information from the first half part of the pipeline. Accordingly, the information pool feeds the second half part with the combination of hierarchical features from the previous layers. Secondly, we employ a compression module to further decrease the size of parameters. Intensive analysis confirms its capacity of trade-off between model complexity and accuracy. Thirdly, by revealing the specific role of activation in deep models, we remove several activation layers in our SR model to retain more information for performance improvement. Extensive experiments show that our s-LWSR, with limited parameters and operations, can achieve similar performance to other cumbersome DL-SR methods