90 research outputs found
A Wideband Electrical Impedance Tomography System based on Sensitive Bioimpedance Spectrum Bandwidth
Ultrasound Guided Regional Anesthesia Training Simulator Using Microsoft Kinect
We present a system for the interactive simulation of ultrasound guided peripheral nerve blocks using a Microsoft Kinect®. The system performs motion tracking of both the ultrasound probe and the nerve block needle. Software generates synthetic ultrasound images from previously captured ultrasound images. Details of the software elements in the system are described. Some of the current challenges and future work in this research are discussed
of Thermal Stability of Copper Oxide Nanowires at Anaerobic Environment
Many metal oxides with promising electrochemical properties were developed recently. Before those metal oxides realize the use as an anode in lithium ion batteries, their thermal stability at anaerobic environment inside batteries should be clearly understood for safety. In this study, copper oxide nanowires were investigated as an example. Several kinds of in situ experiment methods including in situ optical microscopy, in situ Raman spectrum, and in situ transmission electron microscopy were adopted to fully investigate their thermal stability at anaerobic environment. Copper oxide nanowires begin to transform as copper(I) oxide at about 250 ∘ C and finish at about 400 ∘ C. The phase transformation proceeds with a homogeneous nucleation
Research on prognostic risk assessment model for acute ischemic stroke based on imaging and multidimensional data
Accurately assessing the prognostic outcomes of patients with acute ischemic stroke and adjusting treatment plans in a timely manner for those with poor prognosis is crucial for intervening in modifiable risk factors. However, there is still controversy regarding the correlation between imaging-based predictions of complications in acute ischemic stroke. To address this, we developed a cross-modal attention module for integrating multidimensional data, including clinical information, imaging features, treatment plans, prognosis, and complications, to achieve complementary advantages. The fused features preserve magnetic resonance imaging (MRI) characteristics while supplementing clinical relevant information, providing a more comprehensive and informative basis for clinical diagnosis and treatment. The proposed framework based on multidimensional data for activity of daily living (ADL) scoring in patients with acute ischemic stroke demonstrates higher accuracy compared to other state-of-the-art network models, and ablation experiments confirm the effectiveness of each module in the framework
In Situ
Many metal oxides with promising electrochemical properties were developed recently. Before those metal oxides realize the use as an anode in lithium ion batteries, their thermal stability at anaerobic environment inside batteries should be clearly understood for safety. In this study, copper oxide nanowires were investigated as an example. Several kinds of in situ experiment methods including in situ optical microscopy, in situ Raman spectrum, and in situ transmission electron microscopy were adopted to fully investigate their thermal stability at anaerobic environment. Copper oxide nanowires begin to transform as copper(I) oxide at about 250°C and finish at about 400°C. The phase transformation proceeds with a homogeneous nucleation
Circulating microRNAs as novel biomarkers for dilated cardiomyopathy
Background: Circulating microRNAs (miRNAs) potentially carry disease-specific information. In the current study, we aim to characterize the miRNA signature in plasma from dilated cardiomyopathy (DCM) patients and assess the possible correlation between expression levels of circulating miRNAs and symptom severity in DCM patients.
Methods: Using microarray-based miRNA expression profiling, we compared the miRNA expression levels in plasma samples from 4 DCM patients and 3 healthy controls. The expression levels of selected differentially expressed, upregulated miRNAs (miR-3135b, miR-3908 and miR-5571-5p) were validated independently in plasma samples from 19 DCM patients and 20 controls.
Results: We observed that plasma miR-3135b (p < 0.001), miR-3908 (p < 0.001) and miR-5571-5p (p < 0.001) were significantly upregulated in DCM patients. The area under receiver operating characteristic (ROC) curves for the 3 miRNAs ranged from 0.83 to 1.00. Moreover, miR-5571-5p levels in plasma were significantly upregulated with severe New York Heart Association (NYHA) classification (p < 0.05).
Conclusions: The circulating miRNAs (miR-3135b, miR-3908 and miR-5571-5p) have potential as diagnostic biomarkers for DCM. Additionally, miR-5571-5p correlated with NYHA classification.
PbCu(PO4)(OH): Phonon bands, Localized Flat Band Magnetism, Models, and Chemical Analysis
In a series of recent reports, doped lead apatite (LK-99) has been proposed
as a candidate ambient temperature and pressure superconductor. However, from
both an experimental and theoretical perspective, these claims are largely
unsubstantiated. To this end, our synthesis and subsequent analysis of an LK-99
sample reveals a multiphase material that does not exhibit high-temperature
superconductivity. We study the structure of this phase with single-crystal
X-ray diffraction (SXRD) and find a structure consistent with doped
. However, the material is
transparent which rules out a superconducting nature. From ab initio defect
formation energy calculations, we find that the material likely hosts
anions, rather than divalent anions, within the
hexagonal channels and that Cu substitution is highly thermodynamically
disfavored. Phonon spectra on the equilibrium structures reveal numerous
unstable phonon modes. Together, these calculations suggest it is doubtful that
Cu enters the structure in meaningful concentrations, despite initial attempts
to model LK-99 in this way. However for the sake of completeness, we perform ab
initio calculations of the topology, quantum geometry, and Wannier function
localization in the Cu-dominated flat bands of four separate doped structures.
In all cases, we find they are atomically localized by irreps, Wilson loops,
and the Fubini-Study metric. It is unlikely that such bands can support strong
superfluidity, and instead are susceptible to ferromagnetism (or out-of-plane
antiferromagnetism) at low temperatures, which we find in ab initio studies. In
sum, could more likely be
a magnet, rather than an ambient temperature and pressure superconductor.Comment: 39 pages including appendices. Updated defect calculations and
energy-dispersive X-ray spectroscopy dat
SMYD5 Is a Ribosomal Methyltransferase That Catalyzes RPL40 Lysine Methylation To Enhance Translation Output and Promote Hepatocellular Carcinoma
While lysine methylation is well-known for regulating gene expression transcriptionally, its implications in translation have been largely uncharted. Trimethylation at lysine 22 (K22me3) on RPL40, a core ribosomal protein located in the GTPase activation center, was first reported 27 years ago. Yet, its methyltransferase and role in translation remain unexplored. Here, we report that SMYD5 has robust in vitro activity toward RPL40 K22 and primarily catalyzes RPL40 K22me3 in cells. The loss of SMYD5 and RPL40 K22me3 leads to reduced translation output and disturbed elongation as evidenced by increased ribosome collisions. SMYD5 and RPL40 K22me3 are upregulated in hepatocellular carcinoma (HCC) and negatively correlated with patient prognosis. Depleting SMYD5 renders HCC cells hypersensitive to mTOR inhibition in both 2D and 3D cultures. Additionally, the loss of SMYD5 markedly inhibits HCC development and growth in both genetically engineered mouse and patient-derived xenograft (PDX) models, with the inhibitory effect in the PDX model further enhanced by concurrent mTOR suppression. Our findings reveal a novel role of the SMYD5 and RPL40 K22me3 axis in translation elongation and highlight the therapeutic potential of targeting SMYD5 in HCC, particularly with concurrent mTOR inhibition. This work also conceptually broadens the understanding of lysine methylation, extending its significance from transcriptional regulation to translational control
- …