5 research outputs found
IndiumāArsenic Molecules with an Inī¼As Triple Bond: A Theoretical Approach
The effect of substitution on the
potential energy surfaces of
RInī¼AsR (R = F, OH, H, CH<sub>3</sub>, and SiH<sub>3</sub> and
Rā² = SiMeĀ(Si<i>t</i>Bu<sub>3</sub>)<sub>2</sub>,
Si<i>i</i>PrDis<sub>2</sub>, and <i>N</i>-heterocyclic
carbene (NHC)) is determined using density functional theory calculations
(M06-2X/Def2-TZVP, B3PW91/Def2-TZVP, and B3LYP/LANL2DZ+dp). The computational
studies demonstrate that all of the triply bonded RInī¼AsR species
prefer to adopt a bent geometry, which is consistent with the valence
electron model. The theoretical studies show that RInī¼AsR molecules
that have smaller substituents are kinetically unstable with respect
to their intramolecular rearrangements. However, triply bonded Rā²Inī¼AsRā²
species that have bulkier substituents (Rā² = SiMeĀ(Si<i>t</i>Bu<sub>3</sub>)<sub>2</sub>, Si<i>i</i>PrDis<sub>2</sub>, and NHC) occupy minima on the singlet potential energy surface,
and they are both kinetically and thermodynamically stable. That is,
the electronic and steric effects of bulky substituents play an important
role in making molecules that feature an Inī¼As triple bond
viable as a synthetic target. Moreover, two valence bond models are
used to interpret the bonding character of the Inī¼As triple
bond. One is model [A], which is best represented as . This interprets the bonding
conditions for RInī¼AsR molecules that feature small ligands.
The other is model [B], which is best represented as . This explains the bonding
character of RInī¼PAsR molecules that feature large substituents
Triply Bonded Galliumī¼Phosphorus Molecules: Theoretical Designs and Characterization
The effect of substitution on the
potential energy surfaces of triple-bonded RGaī¼PR (R = F, OH,
H, CH<sub>3</sub>, SiH<sub>3</sub>, SiMeĀ(Si<i>t</i>Bu<sub>3</sub>)<sub>2</sub>, Si<i>i</i>PrDis<sub>2</sub>, Tbt
(C<sub>6</sub>H<sub>2</sub>-2,4,6-{CHĀ(SiMe<sub>3</sub>)<sub>2</sub>}<sub>3</sub>), and Ar* (C<sub>6</sub>H<sub>3</sub>-2,6-(C<sub>6</sub>H<sub>2</sub>-2,4,6-<i>i</i>-Pr<sub>3</sub>)<sub>2</sub>)) compounds was theoretically examined by using density functional
theory (i.e., M06-2X/Def2-TZVP, B3PW91/Def2-TZVP, and B3LYP/LANL2DZ+dp).
The theoretical evidence strongly suggests that all of the triple-bonded
RGaī¼PR species prefer to select a bent form with an angle (ā GaāPāR)
of about 90Ā°. Moreover, the theoretical observations indicate
that only the bulkier substituents, in particular, for the strong
donating groups (e.g., SiMeĀ(Si<i>t</i>Bu<sub>3</sub>)<sub>2</sub> and Si<i>i</i>PrDis<sub>2</sub>) can efficiently
stabilize the Gaī¼P triple bond. In addition, the bonding analyses
(based on the natural bond orbital, the natural resonance theory,
and the charge decomposition analysis) reveal that the bonding characters
of such triple-bonded RGaī¼PR molecules should be regarded as Rā²Gaī»āPRā². In other words, the Gaī¼P triple bond involves one traditional
Ļ bond, one traditional Ļ bond, and one donorāacceptor
Ļ bond. Accordingly, the theoretical conclusions strongly suggest
that the Gaī¼P triple bond in such acetylene analogues (RGaī¼PR)
should be very weak
Triple-Bonded Boronī¼Phosphorus Molecule: Is That Possible?
The effect of substitution on the
potential energy surfaces of
RBī¼PR (R = H, F, OH, SiH<sub>3</sub>, and CH<sub>3</sub>) is
studied using density functional theories (M06-2X/Def2-TZVP, B3PW91/Def2-TZVP,
and B3LYP/LANL2DZ+dp). There is significant theoretical evidence that
RBī¼PR compounds with smaller substituents are fleeting intermediates,
so they would be difficult to be detected experimentally. These theoretical
studies using the M06-2X/Def2-TZVP method demonstrate that only the
triply bonded Rā²Bī¼PRā² molecules bearing sterically
bulky groups (Rā² = Tbt (=C<sub>6</sub>H<sub>2</sub>-2,4,6-{CHĀ(SiMe<sub>3</sub>)<sub>2</sub>}<sub>3</sub>), SiMeĀ(Si<i>t</i>Bu<sub>3</sub>)<sub>2</sub>, Ar* (=C<sub>6</sub>H<sub>3</sub>-2,6-(C<sub>6</sub>H<sub>2</sub>-2,4,6-<i>i</i>-Pr<sub>3</sub>)<sub>2</sub>), and Si<i>i</i>PrDis<sub>2</sub>) are significantly
stabilized and can be isolated experimentally. Using the simple valence-electron
bonding model and some sophisticated theories, the bonding character
of Rā²Bī¼PRā² should be viewed as Rā²BI PRā². The present
theoretical observations indicate that both the electronic and the
steric effect of bulkier substituent ligands play a key role in making
triply bonded Rā²Bī¼PRā² species synthetically accessible
and isolable in a stable form
Substituent Effects on BoronāBismuth Triple Bond: A New Target for Synthesis
The
substituent effects on the potential energy surfaces of RBī¼BiR
(R = F, OH, H, CH<sub>3</sub>, SiH<sub>3</sub>, Tbt, Ar*, SiMeĀ(Si<i>t</i>Bu<sub>3</sub>)<sub>2</sub>, and Si<i>i</i>PrDis<sub>2</sub>) are determined using density functional theories (M06-2X/Def2-TZVP,
B3PW91/Def2-TZVP, and B3LYP/LANL2DZ+dp). The theoretical results show
that all of the triply bonded RBī¼BiR molecules prefer to adopt
a bent geometry (i.e., ā RBBi ā 180Ā° and ā BBiR
ā 90Ā°), which agrees well with the valence-electron bonding
model. It is also demonstrated that the smaller groups, such as R
= H, F, OH, CH<sub>3</sub>, and SiH<sub>3</sub>, neither kinetically
nor thermodynamically stabilize the triply bonded RBī¼BiR compounds,
except for H<sub>3</sub>SiBī¼BiSiH<sub>3</sub>. However, triply
bonded Rā²Bī¼BiRā² molecules that feature bulkier
substituents (Rā² = Si<i>i</i>PrDis<sub>2</sub>, SiMeĀ(Si<i>t</i>Bu<sub>3</sub>)<sub>2</sub>, Tbt, and Ar*) are predicted
to have a thermodynamic and kinetic global minimum. This theoretical
study finds that both the steric and the electronic effects of bulkier
substituent groups play a significant role in forming triply bonded
RBī¼BiR species that are experimentally obtainable and isolable
in a stable form
Total Synthesis of (+)-Antrocin and Its Diastereomer and Clarification of the Absolute Stereochemistry of (ā)-Antrocin
Using 2,2-dimethyl
cyclohexanone as the starting compound, (+)-antrocin
and its diastereomer have been synthesized. The absolute stereochemistry
of (ā)-antrocin, a natural sesqui-terpenoid and an antagonist
in some types of cancer cells, was clarified using the character data
of (+)-antrocin. The synthetic procedure involved two key steps: (1)
the reaction of vinyl magnesium bromide with 2,2-dimethyl-6-<i>t</i>-butyl-dimethyl-silyoxy-methyl-1-cyclo-hexanone to give
a vinyl cyclohexanol derivative and (2) a highly stereoselective intramolecular
DielsāAlder (IMDA) reaction of the camphanate-containing triene
intermediate. The relative energy levels of the possible transition
states of the IMDA reaction of the camphanate-containing triene were
obtained from density functional theory calculations, proving the
stereospecific formation of the target molecule