Regiospecific Three-Component Aminofluorination of Olefins via Photoredox Catalysis

Direct visible-light-mediated aminofluorination of styrenes has been developed with high regioselectivity. Shelf-stable <i>N</i>-Ts-protected 1-aminopyridine salt was used as the nitrogen-radical precursor, and the commercially available hydrogen fluoride-pyridine was used as the nucleophilic fluoride source. The synthesis of an analogue of <b>LY503430</b> was performed to demonstrate the synthetic value of this strategy

Direct Decarboxylative–Decarbonylative Alkylation of α‑Oxo Acids with Electrophilic Olefins via Visible-Light Photoredox Catalysis

The decarbonylation of primary, secondary, and tertiary alkyl-substituted acyl radicals has been investigated through photoredox catalysis. A series of quaternary carbons and γ-ketoesters have been directly constructed by the photoredox 1,4-conjugate addition of the corresponding alkyl ketoacids with electrophilic alkenes. And, the tertiary alkyl ketoacids have proved to be good precursors of tertiary alkyl radicals