1-(4-Fluoro­phen­yl)-3-hydr­oxy-3-phenyl­prop-2-en-1-one

In the crystal structure the title compound, C15H11FO2, the molecule exists in the enol form. It is stabilized by an intra­molecular O—H⋯O hydrogen bond, in which the donor O—H and acceptor H⋯O distances are almost equal. The dihedral angle between the two benzene rings is 22.30 (4)°

Chinese industrial air pollution emissions based on the continuous emission monitoring systems network

As the world's largest industrial producer, China has generated large amount of industrial atmospheric pollution, particularly for particulate matter (PM), SO2 and NOx emissions. A nationwide, time-varying, and up-to-date air pollutant emission inventory by industrial sources has great significance to understanding industrial emission characteristics. Here, we present a nationwide database of industrial emissions named Chinese Industrial Emissions Database (CIED), using the real smokestack concentrations from China's continuous emission monitoring systems (CEMS) network during 2015-2018 to enhance the estimation accuracy. This hourly, source-level CEMS data enables us to directly estimate industrial emission factors and absolute emissions, avoiding the use of many assumptions and indirect parameters that are common in existing research. The uncertainty analysis of CIED database shows that the uncertainty ranges are quite small, within ±7.2% for emission factors and ±4.0% for emissions, indicating the reliability of our estimates. This dataset provides specific information on smokestack concentrations, emissions factors, activity data and absolute emissions for China's industrial emission sources, which can offer insights into associated scientific studies and future policymaking

Two NHX-type transporters from Helianthus tuberosus improve the tolerance of rice to salinity and nutrient deficiency stress.

The NHX-type cation/H+ transporters in plants have been shown to mediate Na+ (K+ )/H+ exchange for salinity tolerance and K+ homoeostasis. In this study, we identified and characterized two NHX homologues, HtNHX1 and HtNHX2 from an infertile and salinity tolerant species Helianthus tuberosus (cv. Nanyu No. 1). HtNHX1 and HtNHX2 share identical 5'- and 3'-UTR and coding regions, except for a 342-bp segment encoding 114 amino acids (L272 to Q385 ) which is absent in HtNHX2. Both hydroponics and soil culture experiments showed that the expression of HtNHX1 or HtNHX2 improved the rice tolerance to salinity. Expression of HtNHX2, but not HtNHX1, increased rice grain yield, harvest index, total nutrient uptake under K+ -limited salt-stress or general nutrient deficiency conditions. The results provide a novel insight into NHX function in plant mineral nutrition

Ethyl 7-amino-1-cyclo­propyl-6-fluoro-8-meth­oxy-4-oxo-1,4-dihydro­quinoline-3-carboxyl­ate monohydrate

In the title compound, C16H17FN2O4·H2O, the dihedral angle between the heterocyclic ring and the benzene ring is 5.77 (9)°, that between the heterocycle and the ethoxy­carbonyl plane is 15.5 (1)°, and that between the heterocyclic ring and the cyclopropane ring is 67.75 (13)°. In the crystal structure, mol­ecules are linked into a ribbon-like structure along the c axis by N—H⋯O and O—H⋯O hydrogen bonds

Generation of Oligodendrocyte Progenitor Cells From Mouse Bone Marrow Cells.

Oligodendrocyte progenitor cells (OPCs) are a subtype of glial cells responsible for myelin regeneration. Oligodendrocytes (OLGs) originate from OPCs and are the myelinating cells in the central nervous system (CNS). OLGs play an important role in the context of lesions in which myelin loss occurs. Even though many protocols for isolating OPCs have been published, their cellular yield remains a limit for clinical application. The protocol proposed here is novel and has practical value; in fact, OPCs can be generated from a source of autologous cells without gene manipulation. Our method represents a rapid, and high-efficiency differentiation protocol for generating mouse OLGs from bone marrow-derived cells using growth-factor defined media. With this protocol, it is possible to obtain mature OLGs in 7-8 weeks. Within 2-3 weeks from bone marrow (BM) isolation, after neurospheres formed, the cells differentiate into Nestin+ Sox2+ neural stem cells (NSCs), around 30 days. OPCs specific markers start to be expressed around day 38, followed by RIP+O4+ around day 42. CNPase+ mature OLGs are finally obtained around 7-8 weeks. Further, bone marrow-derived OPCs exhibited therapeutic effect in shiverer (Shi) mice, promoting myelin regeneration and reducing the tremor. Here, we propose a method by which OLGs can be generated starting from BM cells and have similar abilities to subventricular zone (SVZ)-derived cells. This protocol significantly decreases the timing and costs of the OLGs differentiation within 2 months of culture