Monoclinic form of (Z)-1-ferrocenyl-3-(3-hy­droxy­anilino)but-2-en-1-one

The title compound, [Fe(C5H5)(C15H14NO2)], is a monoclinic polymorph of the previously reported triclinic form [Shi et al. (2006 ▶). Acta Cryst. C62, m407–m410]. The polymorphs feature the same strong intra­molecular N—H⋯O=C hydrogen bonds, but show different packing modes. The mol­ecules in the monoclinic form associate into double chains via O—H⋯O=C and (Cp)C—H⋯O—H inter­actions

7-Methyl-9-p-tolyl-4,9-dihydro­furo[3,4-b]quinolin-1(3H)-one

In the title compound, C19H17NO2, the dihydro­pyridine ring adopts a flattened boat conformation while the furan­one ring is almost planar (r.m.s. deviation 0.018 Å). The mol­ecules are linked into chains along the b axis by N—H⋯O inter­molecular hydrogen bonds. In addition, C—H⋯π inter­actions involving the phenyl ring of the tolyl group as π acceptor are observed

Recombinant expression and functional analysis of a Chlamydomonas reinhardtii bacterial-type phosphoenolpyruvate carboxylase gene fragment

To investigate the function of a bacterial-type phosphoenolpyruvate carboxylase (PEPC2) derived from photosynthetically-grown Chlamydomonas reinhardtii, a fragment of the pepc2 gene was cloned and expressed in Escherichia coli. After optimal induction for 6 h, PEPC activity in the reverse mutant was lower than wild type (0.9 vs. 1.7 U/mg protein), and soluble protein was also lower than wild type (119 vs. 186 mg/g dry wt). In contrast, the total lipid content was increased from 56 (in wild type) to 71 mg/g dry wt, despite the growth rate being slightly diminished. The changes in PEPC activity, soluble protein and total lipid in the forward mutant were the opposite (2.4 U/mg, 230 mg/g, and 44 mg/g dry wt, respectively). Together, these data indicate that PEPC may function as a metabolic pivot in the regulation of protein and lipid accumulation in this alga

Cinchonidinium chloride monohydrate

In the title salt, C19H23N2O+·Cl−·H2O, the ions and the water mol­ecule are held together by O—H⋯Cl, N—H⋯Cl, O—H⋯O, O—H⋯N and C—H⋯Cl hydrogen bonds, forming a three-dimensional framework. The vinyl group is disordered over two orientations with refined occupancies of 0.564 (16) and 0.436 (16). The cell parameters of the title compound have been reported previously [Griffiths (1952 ▶). Acta Cryst. 5, 290–291]

Protection effect of Emodin pretreatment on intestinal I-RI damage of intestinal mucosa in ratsa

AbstractObjectiveTo tinvestigate the protective effect and mechanism of emodin pretreatment on intestinal mucosa of rats with intestinal ischemia-reperfusion injury.MethodsA total of 50 SD rats were randomly divided into control group, model group, emodin groups of low, medium and high dose, with 10 in each group. Ischemia-reperfusion injury (I-RI) mode was established by using noninvasive clamp on superior mesentericartery (SMA). Control group and model group were pretreated with 0.5% sodium carboxymethyl cellulose solution lavage 2 h before operation, emodin groups of low, medium and high dose were given emodin lavage with 20, 40, 60 mg/kg pretreatment, femoral venous blood before the lavage pretreatment (T0) and 1 h ischemia (T1), and inferior vena venous blood after 1 h of reperfusion (T2) were extracted from each group of rats for detection of serum level of intestinal fatty acid binding protein (I-FABP), tumor necrosis factor (TNF-α), endotoxin, interleukin 6 (IL-6), and the content of diamine oxidase (DAO); After model establishment, the rats were sacrificed, intestine homogenate was prepared by using blind intestinal tissue to detect intestinal tissue myeloperoxidase (MPO), malondialdehyde (MDA) and superoxide dismutase (SOD) levels. And upper small intestine tissue was retrieved, followed by fixation and conventional HE staining to observe intestinal tissue morphology under light microscopy.ResultsIn emodin groups of low, medium and high dose at T1 and T2, I-FABP, TNF-α, endotoxin, IL-6 and DAO level were significantly lower than that of model group (P<0.05); in emodin group of low, medium and high dose, MPO and MDA content in intestinal tissue homogenate was significantly lower than that in model group (P<0.05), SOD level was significantly higher than that of model group (P<0.05). Intestinal damage of emodin low, medium and high dose groups were significantly lighter than model group.ConclusionsEmodin pretreatment has certain protective effect on intestinal mucosa in ischemia reperfusion injury

Supersensitive sensing of quantum reservoirs via breaking antisymmetric coupling

We investigate the utilization of a single generalized dephasing qubit for sensing a quantum reservoir, where the antisymmetric coupling between the qubit and its reservoir is broken. It is found that in addition to the decay factor encoding channel, the antisymmetric coupling breaking gives rise to another phase factor encoding channel. We introduce an optimal measurement for the generalized dephasing qubit which enables the practical measurement precision to reach the theoretical ultimate precision quantified by the quantum signal-to-noise ratio (QSNR). As an example, the generalized dephasing qubit is employed to estimate the $s$-wave scattering length of an atomic Bose-Einstein condensate. It is found that the phase-induced QSNR caused by the antisymmetric coupling breaking is at least two orders of magnitude higher than the decay-induced QSNR at the millisecond timescale and the optimal relative error can achieve a scaling $\propto 1/t$ with $t$ being the encoding time in long-term encoding. Our work opens a way for supersensitive sensing of quantum reservoirs

Effectiveness of Shuxuening injection in coronary heart disease: a systematic review and meta-analysis

Background: Coronary heart disease (CHD) poses a serious threat to public health, and the current medical management still faces significant challenges. Reliable evidence on the efficacy of Shuxuening injection (SXNI) in CHD is still lacking, even though it is widely used in China.Purpose: To evaluate the efficacy of SXNI combination therapy in treating CHD.Methods: A systematic search of eight databases was conducted to identify relevant randomized controlled trials (RCTs) from the inception of each database until June 2023. ROB 2.0, RevMan 5.4, and Stata 15.1 were used for quality evaluation and data analysis. The Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) approach was used to evaluate the quality of evidence.Results: A total of 3,779 participants from 39 studies were included. The results showed SXNI combination therapy increased the clinical efficacy and decreased the frequency and duration of angina. Furthermore, SXNI combination therapy improved cardiac function of patients by decreasing LVEDD, and increased CI, CO, and LVEF. It also improved blood lipid profiles by increasing HDL, decreasing TC, TG, and LDL. The thrombosis factors of patients were also improved by decreasing FIB, PV, HCT, and HS. Moreover, SXNI combination therapy was superior to the conventional treatment in improving CRP levels, increasing ECG efficacy and BNP. However, due to the limited safety information, reliable safety conclusions could not be drawn. Furthermore, the levels of evidence ranged from very low to moderate due to publication bias and heterogeneity.Conclusion: SXNI can effectively improve angina symptoms, clinical efficacy, cardiac function, blood lipid indicators, and thrombosis factors of patients with CHD. However, more multi-center and large-sample studies are needed to confirm the conclusions due to the limitations of this study.Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=399606; Identifier: CRD42023433292