Life fingerprints of nuclear reactions in the body of animals

Nuclear reactions are a very important natural phenomenon in the universe. On the earth, cosmic rays constantly cause nuclear reactions. High energy beams created by medical devices also induce nuclear reactions in the human body. The biological role of these nuclear reactions is unknown. Here we show that the in vivo biological systems are exquisite and sophisticated by nature in influence on nuclear reactions and in resistance to radical damage in the body of live animals. In this study, photonuclear reactions in the body of live or dead animals were induced with 50-MeV irradiation. Tissue nuclear reactions were detected by positron emission tomography (PET) imaging of the induced beta+ activity. We found the unique tissue "fingerprints" of beta+ (the tremendous difference in beta+ activities and tissue distribution patterns among the individuals) are imprinted in all live animals. Within any individual, the tissue "fingerprints" of 15O and 11C are also very different. When the animal dies, the tissue "fingerprints" are lost. The biochemical, rather than physical, mechanisms could play a critical role in the phenomenon of tissue "fingerprints". Radiolytic radical attack caused millions-fold increases in 15O and 11C activities via different biochemical mechanisms, i.e. radical-mediated hydroxylation and peroxidation respectively, and more importantly the bio-molecular functions (such as the chemical reactivity and the solvent accessibility to radicals). In practice biologically for example, radical attack can therefore be imaged in vivo in live animals and humans using PET for life science research, disease prevention, and personalized radiation therapy based on an individual's bio-molecular response to ionizing radiation

Gapless topological Fulde-Ferrell superfluidity in spin-orbit coupled Fermi gases

Topological superfluids usually refer to a superfluid state which is gapped in the bulk but metallic at the boundary. Here we report that a gapless, topologically non-trivial superfluid with inhomogeneous Fulde-Ferrell pairing order parameter can emerge in a two-dimensional spin-orbit coupled Fermi gas, in the presence of both in-plane and out-of-plane Zeeman fields. The Fulde-Ferrell pairing - induced by the spin-orbit coupling and in-plane Zeeman field - is responsible for this gapless feature. This exotic superfluid has a significant Berezinskii-Kosterlitz-Thouless (BKT) transition temperature and has robust Majorana edge modes against disorder owing to its topological nature.Comment: 5 pages, 5 figures; add the results on the critical BKT temperature and superfluid density, as well as the discussion on the robustness of the chiral edge states against disorde

Semi-supervised Counting via Pixel-by-pixel Density Distribution Modelling

This paper focuses on semi-supervised crowd counting, where only a small portion of the training data are labeled. We formulate the pixel-wise density value to regress as a probability distribution, instead of a single deterministic value. On this basis, we propose a semi-supervised crowd-counting model. Firstly, we design a pixel-wise distribution matching loss to measure the differences in the pixel-wise density distributions between the prediction and the ground truth; Secondly, we enhance the transformer decoder by using density tokens to specialize the forwards of decoders w.r.t. different density intervals; Thirdly, we design the interleaving consistency self-supervised learning mechanism to learn from unlabeled data efficiently. Extensive experiments on four datasets are performed to show that our method clearly outperforms the competitors by a large margin under various labeled ratio settings. Code will be released at https://github.com/LoraLinH/Semi-supervised-Counting-via-Pixel-by-pixel-Density-Distribution-Modelling.Comment: This is the technical report of a paper that was submitted to IEEE Transactions and is now under revie

Modeling Multiple Views via Implicitly Preserving Global Consistency and Local Complementarity

While self-supervised learning techniques are often used to mining implicit knowledge from unlabeled data via modeling multiple views, it is unclear how to perform effective representation learning in a complex and inconsistent context. To this end, we propose a methodology, specifically consistency and complementarity network (CoCoNet), which avails of strict global inter-view consistency and local cross-view complementarity preserving regularization to comprehensively learn representations from multiple views. On the global stage, we reckon that the crucial knowledge is implicitly shared among views, and enhancing the encoder to capture such knowledge from data can improve the discriminability of the learned representations. Hence, preserving the global consistency of multiple views ensures the acquisition of common knowledge. CoCoNet aligns the probabilistic distribution of views by utilizing an efficient discrepancy metric measurement based on the generalized sliced Wasserstein distance. Lastly on the local stage, we propose a heuristic complementarity-factor, which joints cross-view discriminative knowledge, and it guides the encoders to learn not only view-wise discriminability but also cross-view complementary information. Theoretically, we provide the information-theoretical-based analyses of our proposed CoCoNet. Empirically, to investigate the improvement gains of our approach, we conduct adequate experimental validations, which demonstrate that CoCoNet outperforms the state-of-the-art self-supervised methods by a significant margin proves that such implicit consistency and complementarity preserving regularization can enhance the discriminability of latent representations.Comment: Accepted by IEEE Transactions on Knowledge and Data Engineering (TKDE) 2022; Refer to https://ieeexplore.ieee.org/document/985763

Traveling kink oscillations of coronal loops launched by a solar flare

We investigate the traveling kink oscillation triggered by a solar flare on 2022 September 29. The observational data is mainly measured by the Solar Upper Transition Region Imager (SUTRI), the Atmospheric Imaging Assembly (AIA), and the Spectrometer/Telescope for Imaging X-rays (STIX). The transverse oscillations with apparent decaying in amplitudes, which are nearly perpendicular to the oscillating loop, are observed in passbands of SUTRI 465 A, AIA 171 A, and 193 A. The decaying oscillation is launched by a solar flare erupted closely to one footpoint of coronal loops, and then it propagates along several loops. Next, the traveling kink wave is evolved to a standing kink oscillation. To the best of our knowledge, this is the first report of the evolution of a traveling kink pulse to a standing kink wave along coronal loops. The standing kink oscillation along one coronal loop has a similar period of about 6.3 minutes at multiple wavelengths, and the decaying time is estimated to about 9.6-10.6 minutes. Finally, two dominant periods of 5.1 minutes and 2.0 minutes are detected in another oscillating loop, suggesting the coexistence of the fundamental and third harmonics.Comment: 8 pages, 8 figures, accepted by A&

In vitro cellular uptake of evodiamine and rutaecarpine using a microemulsion

Yong-Tai Zhang, Zhe-Bin Huang, Su-Juan Zhang, Ji-Hui Zhao, Zhi Wang, Ying Liu, Nian-Ping FengDepartment of Pharmaceutics, Shanghai University of Traditional Chinese Medicine, Shanghai, The People's Republic of ChinaObjective: To investigate the cellular uptake of evodiamine and rutaecarpine in a microemulsion in comparison with aqueous suspensions and tinctures.Materials and methods: A microemulsion was prepared using the dropwise addition method. Mouse skin fibroblasts were cultured in vitro to investigate the optimal conditions for evodiamine and rutaecarpine uptake with different drug concentrations and administration times. Under optimal conditions, the cellular uptake of microemulsified drugs was assayed and compared to tinctures and aqueous suspensions. Rhodamine B labeling and laser scanning confocal microscopy (LSCM) were used to explore the distribution of fluorochrome transferred with the microemulsion in fibroblasts. Cellular morphology was also investigated, using optical microscopy to evaluate microemulsion-induced cellular toxicity.Results: The maximum cellular drug uptake amounts were obtained with a 20% concentration (v/v) of microemulsion and an 8 hour administration time. Drug uptake by mouse skin fibroblasts was lowest when the drugs were loaded in microemulsion. After incubation with rhodamine B-labeled microemulsion for 8 hours, the highest fluorescence intensity was achieved, and the fluorochrome was primarily distributed in the cytochylema. No obvious cellular morphologic changes were observed with the administration of either the microemulsion or the aqueous suspension; for the tincture group, however, massive cellular necrocytosis was observed.Conclusion: The lower cellular uptake with microemulsion may be due to the fact that most of the drug loaded in the microemulsion vehicle was transported via the intercellular space, while a small quantity of free drug (released from the vehicle) was ingested through transmembrane transport. Mouse skin fibroblasts rarely endocytosed evodiamine and rutaecarpine with a microemulsion as the vehicle. The microemulsion had no obvious effect on cellular morphology, suggesting there is little or no cellular toxicity associated with the administration of microemulsion on mouse skin fibroblasts.Keywords: mouse skin fibroblasts, evodiamine, rutaecarpine, microemulsion, cellular uptake, in vitr