Prediction model with paraquat concentrations and time interval.

<p>Model 1: patients who were admitted to our hospital within 12 h after ingestion of paraquat.</p><p>Model 2: patients who were admitted to our hospital within 24 h after ingestion of paraquat.</p><p>Model 3: all patients who were admitted our hospital at any time after ingestion of paraquat.</p><p>Prediction model with paraquat concentrations and time interval.</p

Contour graph showing relation between plasma paraquat concentration (µg/ml), time after ingestion, and probability of survival.

<p>A. Probability curve of patients who were admitted to our hospital within 12 h after ingestion of paraquat. B. Probability curve of patients who were admitted to our hospital within 24 h after ingestion of paraquat. C. Probability curve of all patients who were admitted to our hospital at any time after ingestion of paraquat.</p

Internal and external validation of our developed model.

<p>Model 1: patients who were admitted to our hospital within 12 h after ingestion of paraquat.</p><p>Model 2: patients who were admitted to our hospital within 24 h after ingestion of paraquat.</p><p>Model 3: all patients who were admitted to our hospital at any time after ingestion of paraquat.</p><p>Internal and external validation of our developed model.</p

Table1_Corrected QTc interval combined with troponin value and mortality in acute ischemic stroke.docx

Background and PurposeCardiac biomarkers including, elevated troponin (ET) and prolonged heart rate-corrected QT (PQTc) interval on electrocardiography are known to frequent and have a prognostic significance in patients with acute ischemic stroke (AIS). However, it is still challenging to practically apply the results for appropriate risk stratification. This study evaluate whether combining ET and PQTc interval can better assess the long-term prognosis in AIS patients.MethodsIn this prospectively registered observational study between May 2007 and December 2011, ET was defined as serum troponin-I ≥ 0.04 ng/ml and PQTc interval was defined as the highest tertile of sex-specific QTc interval (men ≥ 469 ms or women ≥ 487 ms).ResultsAmong the 1,668 patients [1018 (61.0%) men; mean age 66.0 ± 12.4 years], patients were stratified into four groups according to the combination of ET and PQTc intervals. During a median follow-up of 33 months, ET (hazard ratio [HR]: 4.38, 95% confidence interval [CI]: 2.94–6.53) or PQTc interval (HR: 1.53, 95% CI: 1.16–2.01) alone or both (HR: 1.77, 95% CI: 1.16–2.71) was associated with increased all-cause mortality. Furthermore, ET, PQTc interval alone or both was associated with vascular death, whereas only ET alone was associated with non-vascular death. Comorbidity burden, especially atrial fibrillation and congestive heart failure, and stroke severity gradually increased both with troponin value and QTc-interval.ConclusionsIn patients with AIS, combining ET and PQTc interval on ECG enhances risk stratification for long-term mortality while facilitating the discerning ability for the burden of comorbidities and stroke severity.</p

Multiple linear regression analysis between plasma α-klotho levels and other parameters in patients with diabetes (<i>n</i> = 147).

<p>ALT, alanine aminotransferase; ACR, albumin creatinine ratio; PCR, protein creatinine ratio. *Log transformed data before analysis.</p

Correlations between plasma α-klotho levels and other parameters in patients with diabetes (n = 147).

<p>SBP, systolic blood pressure; DBP, diastolic blood pressure; AST, aspartate aminotransferase; ALT, alanine aminotransferase; eGFR, estimated glomerular filtration rate; ACR, albumin creatinine ratio; PCR, protein creatinine ratio. *Log transformed data before analysis, <i>r:</i> Pearson correlation coefficient.</p

Clinical characteristics and laboratory findings of non-diabetic control subjects and type 2 diabetic patients.

<p>Values are mean ± SD, number of patients (%), median (interquartile range), and geometric means (95% CI) unless otherwise indicated. DM, diabetes mellitus; SBP, systolic blood pressure; DBP, diastolic blood pressure; AST, aspartate aminotransferase; ALT, alanine aminotransferase; eGFR, estimated glomerular filtration rate. *<i>P</i>-values were calculated using log-transformed values. ^†<i>P</i>-values were calculated by Student's <i>t</i>-test, Mann-Whitney u-test or Pearson <i>χ²</i> test where appropriate.</p

Plasma (A,B) and urine (C,D) levels of soluble α-klotho in normal participants (<i>n</i> = 25) and patients with type 2 diabetes (<i>n</i> = 147).

<p>Plasma and urine α-klotho levels were higher in diabetes patients with relatively preserved renal function than the non-diabetic controls (A,C). The diabetes patients were categorized into 3 groups according to urine ACR: ACR <30 mg/g creatinine (normoalbuminuria group, <i>n</i> = 75), ACR 30–299 mg/g creatinine (microalbuminuria group, <i>n</i> = 42), and ACR ≥300 mg/g creatinine (macroalbuminuria group, <i>n</i> = 30). Plasma α-klotho levels decreased in proportion to urinary albumin excretion, although urinary α-klotho levels were stable with increasing urinary albumin excretion (B,D). Data of non-diabetic control are expressed as a shaded area for the reference (B, D). Data are presented as geometric means and 95% CIs as an error bar plot. <i>P</i>-values calculated using the log-transformed values are shown in the graph. normo; normoalbuminuria, micro; microalbuminuria, macro; macroalbuminuria.</p

Baseline clinical and laboratory parameters in patients with type 2 diabetes according to albuminuria status.

<p>Values are mean ± SD, number of patients (%), median (interquartile range), and geometric means (95% CI) unless otherwise indicated. DR, diabetic retinopathy; DN, diabetic neuropathy; SBP, systolic blood pressure; DBP, diastolic blood pressure; TC, total cholesterol; TG, triglycerides; TB, total bilirubin; DB, direct bilirubin; UA, uric acid; Ca, calcium; P, phosphorous; Scr, serum creatinine; eGFR, estimated glomerular filtration rate; CRP, C-reactive protein; ACR, Urine albumin creatinine ratio; PCR, Urine protein creatinine ratio. *<i>P</i>-values were calculated using log-transformed values. ^†<i>P</i>-values were calculated by ANOVA or Pearson <i>χ²</i> test where appropriate. The same superscripted letters indicate statistical significance according to Tukey's multiple comparison test.</p

Patient Characteristics at Baseline.

<p>Patient Characteristics at Baseline.</p