On Resource Pooling and Separation for LRU Caching

Caching systems using the Least Recently Used (LRU) principle have now become ubiquitous. A fundamental question for these systems is whether the cache space should be pooled together or divided to serve multiple flows of data item requests in order to minimize the miss probabilities. In this paper, we show that there is no straight yes or no answer to this question, depending on complex combinations of critical factors, including, e.g., request rates, overlapped data items across different request flows, data item popularities and their sizes. Specifically, we characterize the asymptotic miss probabilities for multiple competing request flows under resource pooling and separation for LRU caching when the cache size is large. Analytically, we show that it is asymptotically optimal to jointly serve multiple flows if their data item sizes and popularity distributions are similar and their arrival rates do not differ significantly; the self-organizing property of LRU caching automatically optimizes the resource allocation among them asymptotically. Otherwise, separating these flows could be better, e.g., when data sizes vary significantly. We also quantify critical points beyond which resource pooling is better than separation for each of the flows when the overlapped data items exceed certain levels. Technically, we generalize existing results on the asymptotic miss probability of LRU caching for a broad class of heavy-tailed distributions and extend them to multiple competing flows with varying data item sizes, which also validates the Che approximation under certain conditions. These results provide new insights on improving the performance of caching systems

Electronic properties study of sensitizing centers in chemical sensitization

Reduction sensitization, sulfur sensitization and sulfur-plus-gold sensitization are th

Dynamic Entity Representations in Neural Language Models

Understanding a long document requires tracking how entities are introduced and evolve over time. We present a new type of language model, EntityNLM, that can explicitly model entities, dynamically update their representations, and contextually generate their mentions. Our model is generative and flexible; it can model an arbitrary number of entities in context while generating each entity mention at an arbitrary length. In addition, it can be used for several different tasks such as language modeling, coreference resolution, and entity prediction. Experimental results with all these tasks demonstrate that our model consistently outperforms strong baselines and prior work.Comment: EMNLP 2017 camera-ready versio

The Regulatory Role of MeAIB in Protein Metabolism and the mTOR Signaling Pathway in Porcine Enterocytes.

Amino acid transporters play an important role in cell growth and metabolism. MeAIB, a transporter-selective substrate, often represses the adaptive regulation of sodium-coupled neutral amino acid transporter 2 (SNAT2), which may act as a receptor and regulate cellular amino acid contents, therefore modulating cellular downstream signaling. The aim of this study was to investigate the effects of MeAIB to SNAT2 on cell proliferation, protein turnover, and the mammalian target of rapamycin (mTOR) signaling pathway in porcine enterocytes. Intestinal porcine epithelial cells (IPEC)-J2 cells were cultured in a high-glucose Dulbecco's modified Eagle's (DMEM-H) medium with 0 or 5 mmoL/L System A amino acid analogue (MeAIB) for 48 h. Cells were collected for analysis of proliferation, cell cycle, protein synthesis and degradation, intracellular free amino acids, and the expression of key genes involved in the mTOR signaling pathway. The results showed that SNAT2 inhibition by MeAIB depleted intracellular concentrations of not only SNAT2 amino acid substrates but also of indispensable amino acids (methionine and leucine), and suppressed cell proliferation and impaired protein synthesis. MeAIB inhibited mTOR phosphorylation, which might be involved in three translation regulators, EIF4EBP1, IGFBP3, and DDIT4 from PCR array analysis of the 84 genes related to the mTOR signaling pathway. These results suggest that SNAT2 inhibition treated with MeAIB plays an important role in regulating protein synthesis and mTOR signaling, and provide some information to further clarify its roles in the absorption of amino acids and signal transduction in the porcine small intestine

Slip history of the 2003 San Simeon earthquake constrained by combining 1-Hz GPS, strong motion, and teleseismic data

The slip history of the 2003 San Simeon earthquake is constrained by combining strong motion and teleseismic data, along with GPS static offsets and 1-Hz GPS observations. Comparisons of a 1-Hz GPS time series and a co-located strong motion data are in very good agreement, demonstrating a new application of GPS. The inversion results for this event indicate that the rupture initiated at a depth of 8.5 km and propagated southeastwards with a speed ~3.0 km/sec, with rake vectors forming a fan structure around the hypocenter. We obtained a peak slip of 2.8 m and total seismic moment of 6.2 × 10^(18) Nm. We interpret the slip distribution as indicating that the hanging wall rotates relative to the footwall around the hypocenter, in a sense that appears consistent with the shape of the mapped fault trace