2-(1H-1,2,3-Benzotriazol-1-yl)-N′-cyclo­pentyl­ideneacetohydrazide

The title compound, C13H15N5O, was synthesized by the reaction of 2-(1H-1,2,3-benzotriazol-1-yl)acetohydrazide with cyclo­penta­none. In the cyclopentane ring, two C atoms and their attached H atoms are disordered over two positions; the site occupancy factors are ca 0.63 and 0.37. In the crystal structure, mol­ecules are linked into infinite chains directed along the b axis by N—H⋯O hydrogen bonds. In addition, there are weak C—H⋯O and C—H⋯N hydrogen bonds, as well as C—H⋯π-ring inter­actions in the structure

Comparative analysis of the secretomes of Schizophyllum commune and other wood-decay basidiomycetes during solid-state fermentation reveals its unique lignocellulose-degrading enzyme system

Additional file 3: Table S2. Identified proteins in the secretomes of four fungi during SSF on Jerusalem artichoke stalk

Bilaterally Combined Electric and Acoustic Hearing in Mandarin-Speaking Listeners: The Population With Poor Residual Hearing

The hearing loss criterion for cochlear implant candidacy in mainland China is extremely stringent (bilateral severe to profound hearing loss), resulting in few patients with substantial residual hearing in the nonimplanted ear. The main objective of the current study was to examine the benefit of bimodal hearing in typical Mandarin-speaking implant users who have poorer residual hearing in the nonimplanted ear relative to those used in the English-speaking studies. Seventeen Mandarinspeaking bimodal users with pure-tone averages of 80 dB HL participated in the study. Sentence recognition in quiet and in noise as well as tone and word recognition in quiet were measured in monaural and bilateral conditions. There was no significant bimodal effect for word and sentence recognition in quiet. Small bimodal effects were observed for sentence recognition in noise (6%) and tone recognition (4%). The magnitude of both effects was correlated with unaided thresholds at frequencies near voice fundamental frequencies (F0s). A weak correlation between the bimodal effect for word recognition and unaided thresholds at frequencies higher than F0s was identified. These results were consistent with previous findings that showed more robust bimodal benefits for speech recognition tasks that require higher spectral resolution than speech recognition in quiet. The significant but small F0-related bimodal benefit was also consistent with the limited acoustic hearing in the nonimplanted ear of the current subject sample, who are representative of the bimodal users in mainland China. These results advocate for a more relaxed implant candidacy criterion to be used in mainland China

China’s wood furniture manufacturing industry: industrial cluster and export competitiveness

China is the largest furniture exporter in the world. Its wood furniture industry has become an important part of the country’s forestry economic development. Hence, investigating China’s furniture industry cluster and export competitiveness is favorable for the sustainable development of China’s forestry industry. This study indicates that, under the guidance of the export-oriented strategy of China’s reform and opening up for 30 years, the country’s furniture industry has formed three big industry areas, namely, the Eastern Pearl River Delta, the Yangtze River Delta, and the Bohai Rim Region. As the strategy shifts from export orientation to a focus on domestic demand, the Midwest area will take over China’s industrial transfer. At present, China’s furniture products have an important position in the world market. In 2010, furniture exports accounted for 27% of the world’s total exports, with wood furniture accounting for $10.6 billion worth of exports, or 58% of China’s total exports of furniture. Among the main export markets, the United States accounted for 39% of China’s total exports. In terms of international furniture trade, an important mutual influence exists between China and the United States. China’s office furniture and kitchen furniture have price advantages, whereas the bedroom furniture lacks price advantages. The production and export of mahogany furniture face the pressure of raw material shortage because of the protection of tropical forest resources. Hence, this challenge puts China’s furniture industry in future competition from emerging countries such as Malaysia

Local Gromov-Witten Invariants are Log Invariants

We prove a simple equivalence between the virtual count of rational curves in the total space of an anti-nef line bundle and the virtual count of rational curves maximally tangent to a smooth section of the dual line bundle. We conjecture a generalization to direct sums of line bundles.Comment: 15 pages, version accepted for publication in Advances in Mathematic

VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters

Overexpression of ATP-binding cassette (ABC) transporters is one of the most important mechanisms responsible for multi-drug resistance (MDR). VS-4718, a tyrosine kinase inhibitor targeting focal adhesion kinase (FAK) with a potential anticancer effect, is currently evaluated in clinical trials. In this study, we investigated whether VS-4718 could reverse MDR mediated by ABC transporters, including ABCB1, ABCG2, and ABCC1. The results showed that VS-4718 significantly reversed ABCB1- and ABCG2-mediated MDR, but not MDR mediated by ABCC1. Treatment of VS-4718 did not alter the protein level and subcellular localization of ABCB1 or ABCG2. Mechanism studies indicated that the reversal effects of VS-4718 were related to attenuation of the efflux activity of ABCB1 and ABCG2 transporters. ATPase analysis indicated that VS-4718 stimulated the ATPase activity of ABCB1 and ABCG2. Docking study showed that VS-4718 interacted with the substrate-binding sites of both ABCB1 and ABCG2, suggesting that VS-4718 may affect the activity of ABCB1 and ABCG2 competitively. This study provided a novel insight for MDR cancer treatment. It indicated that combination of VS-4718 with antineoplastic drugs could attenuate MDR mediated by ABCB1 or ABCG2 in ABCB1- or ABCG2-overexpressing cancer cells