Logistic regression analysis of variables independently associated with false positive or negative results of E_ratio.

<p>E_ratio = elasticity ratio, the ratio between the mean elasticity values in the lesion and in the fatty tissue, CI = Confidence interval, E_mean = mean elasticity value, E_max = maximum elasticity value, Distance from skin = vertical distance from skin to ROI for the fat</p><p>Logistic regression analysis of variables independently associated with false positive or negative results of E_ratio.</p

Images of fibroadenoma in a 42-year-old woman.

<p>For the ROI that is set on the fat tissue showing black color at SWE (E_mean, 3.6 kPa; E_max, 11.3 kPa) (arrows), E_ratio was 5.87 which was false positive result according to the cutoff value of 3.18.</p

Images of invasive ductal carcinoma in a 54-year-old woman.

<p>(A-C) At a single SWE image obtained from the mass, four E_ratios are measured with a fixed ROI for the mass (white arrow) along with four ROIs for the surrounding fat that are set randomly in different four locations (white arrowheads). (A, left) The actual (orange double-headed solid arrow) or vertical (orange double-headed dotted arrow) distance from the center of lesion to the fat ROI, the actual (yellow double-headed solid arrow) or vertical (yellow double-headed dotted arrow) distance from the lesion ROI to the fat ROI, and the vertical distance from the fat ROI to skin (blue double-headed solid arrow) was measured on gray-scale image. (C) For the ROI that is set on the fat tissue showing artifactual vertical light blue color stiffness at SWE (E_mean, 39.0 kPa; E_max, 46.9 kPa) (white arrowhead), E_ratio was 2.73 which was false negative result according to the cutoff value of 3.18.</p

Images of fibrocystic change in a 43-year-old woman.

<p>For the ROI that is set on the lesion showing the vertical stripe pattern of artifacts (arrows) at SWE (E_mean, 48.5 kPa; E_max, 55.3 kPa), E_ratios were 3.77 and 7.68 measured with two different fat ROIs (arrowheads) which were false positive results according to the cutoff value of 3.18.</p

Diagnostic performance of E_ratio for characterization of breast masses, adjusted for location of fat ROI.

<p>AUC = the area under the receiver operating characteristic curve, CI = Confidence interval, E_ratio = elasticity ratio, the ratio between the mean elasticity values in the lesion and in the fatty tissue, ROI = Region of interest</p><p>* Relative location of the ROI for fat to the ROI for lesion</p><p>Diagnostic performance of E_ratio for characterization of breast masses, adjusted for location of fat ROI.</p

Diagnostic performance of E_ratio according to the interquartile range of elasticity value of the fat.

<p>IQR = Interquartile range, AUC = the area under the receiver operating characteristic curve, CI = Confidence interval, E_mean = mean elasticity value of the reference fat, E_max = maximum elasticity value of the reference fat, E_ratio = elasticity ratio, the ratio between the mean elasticity values in the lesion and in the fatty tissue</p><p>Diagnostic performance of E_ratio according to the interquartile range of elasticity value of the fat.</p

The clinical significance of accompanying NME on preoperative MR imaging in breast cancer patients

<div><p>Purpose</p><p>To investigate the significance of accompanying NME in invasive ductal carcinoma (IDC) on preoperative MR imaging and assess the factors affecting the significance.</p><p>Methods</p><p>Between January 2015 and February 2016, 163 consecutive patients with IDC who underwent preoperative MR imaging and subsequent surgery were enrolled and reviewed. Index cancer mass size and total extent with accompanying NME on MR images was measured and compared with pathologic size. Positive NME was defined as pathological result of IDC or DCIS. To identify affecting factors associated with frequency of accompanying NME on MR and positive pathologic result, clinicopathologic features were compared between breast cancers with NME and without NME, and between breast cancers with positive NME and negative NME using the Student t-test or Chi-square test.</p><p>Results</p><p>Of the 163 invasive breast cancers, 123(75.5%) cancers presented as only mass feature and 40(24.5%) cancers had accompanying NME around the index mass. Of the 40 accompanying NME, 22 (55%) had positive pathologic results and 18 (45%) had negative results. The HER2 positive status was significantly associated with positive pathologic results of accompanying NME (<i>P</i> = .016).</p><p>Conclusion</p><p>Accompanying NME on preoperative MR imaging showed malignant pathologic results in 55%. The HER2 positive IDC was more frequently accompanied by malignant NME.</p></div

Characteristics of patients without NME and with accompanying NME in MR imaging.

<p>Characteristics of patients without NME and with accompanying NME in MR imaging.</p

Characteristics of patients with accompanying NME according to pathologic results.

<p>Characteristics of patients with accompanying NME according to pathologic results.</p

Comparison of Malignancy Rates, Clinical and Ultrasonographic Features between Initial and Repeat Bethesda Category III Groups.

<p>*Numbers present the mean±standard deviation</p><p>^aNumber of nodules with suspicious features / total nodules</p><p>^bNumber of patients / total patients</p><p>^cPositive BRAF mutation</p><p>Comparison of Malignancy Rates, Clinical and Ultrasonographic Features between Initial and Repeat Bethesda Category III Groups.</p