Flightless-I Controls Fat Storage in Drosophila

Triglyceride homeostasis is a key process of normal development and is essential for the maintenance of energy metabolism. Dysregulation of this process leads to metabolic disorders such as obesity and hyperlipidemia. Here, we report a novel function of the Drosophila flightless-I (fliI) gene in lipid metabolism. Drosophila fliI mutants were resistant to starvation and showed increased levels of triglycerides in the fat body and intestine, whereas fliI overexpression decreased triglyceride levels. These flies suffered from metabolic stress indicated by increased levels of trehalose in hemolymph and enhanced phosphorylation of eukaryotic initiation factor 2 alpha (eIF2??). Moreover, upregulation of triglycerides via a knockdown of fliI was reversed by a knockdown of desat1 in the fat body of flies. These results indicate that fliI suppresses the expression of desat1, thereby inhibiting the development of obesity; fliI may, thus, serve as a novel therapeutic target in obesity and metabolic diseases

Experimental investigations on the characteristics of snow accretion using the EMU-320 model train

This paper presents a snow accretion test conducted in a climate wind tunnel to investigate the icing process on a model train. The model used within this experiment was the cleaned-up and 2/3-scaled version of EMU-320, which is a high-speed train in Korea. The model was designed without an electronic power source or heat source so that the wheels did not rotate and snow accretion on the model did not occur due to heat sources. To investigate snow accretion, four cases with different ambient temperatures were considered in the climate wind tunnel on Rail Tec Arsenal. Before analyzing the snow accretion on the train, the snow flux and liquid water content of snow were measured so that they could be used as the input conditions for the simulation and to ensure the analysis of the icing process was based on the characteristics of the snow. Both qualitative and quantitative data were obtained, whereby photographs was used for qualitative analysis, and the density of the snow sample and the thickness of snow accreted on the model were used for quantitative analysis. Based on the visual observations, it was deduced that as the ambient temperature increased, the range of the snow accreted was broader. The thickness of snow accreted on the model nose was the largest on the upper and lower part at -3 oC, and on the middle part at -5 oC. Additionally, the cross section of snow accreted was observed to be trench-like. Similar icing processes were observed to occur on the slope of nose. Snow accreted on all components of the bogie, and for all cases, the thickness of snow at wheel was the largest at an arc angle of 40 to 70 o. These detailed data of experimental conditions can be applied as an input to simulations to improve simulations of ice conditions. Thus, they can facilitate the development of appropriate anti-icing designs for trainsComment: 31 pages, 23 Figures, 8 Table

Survivability assessment of Viton in safety-related equipment under simulated severe accident environments

To evaluate equipment survivability of the polymer Viton, used in sealing materials, the effects of its thermal degradation were investigated in severe accident (SA) environment in a nuclear power plant. Viton specimens were prepared and thermally degraded at different SA temperature profiles. Changes in mechanical properties at different temperature profiles in different SA states were investigated. The thermal lag analysis was performed at calculated convective heat transfer conditions to predict the exposure temperature of the polymer inside the safety-related equipment. The polymer that was thermally degraded at postaccident states exhibited the highest change in its mechanical properties, such as tensile strength and elongation

Prevalence of sarcopenia and sarcopenic obesity in Korean adults: The Korean Sarcopenic Obesity Study (KSOS)

*Context:* Sarcopenic obesity (SO), a combination of excess weight and reduced muscle mass and/or strength, is suggested to be associated with an increased risk of adverse health outcomes. 
*Objectives:* To examine the prevalence and characteristics of Sarcopenic and SO defined by using different indices such as Appendicular Skeletal muscle Mass (ASM)/height^2^ and Skeletal Muscle Index (SMI (%): skeletal muscle mass (kg)/weight (kg) × 100) for Korean adults. 
*Methods:* 591 participants were recruited from the Korean Sarcopenic Obesity Study (KSOS) which is an ongoing prospective observational cohort study. Analysis was conducted in 526 participants (328 women, 198 men) who had complete data on body composition using Dual X-ray absorptiometry and computed tomography. 
*Results:* The prevalence of sarcopenia and SO increases with aging. Using two or more standard deviations (SD) of ASM/height^2^ below reference values from young, healthy adults as a definition of sarcopenia, the prevalence of sarcopenia and SO was 6.3% and 1.3% in men and 4.1% and 1.7% in women over 60 years of age. However, using two or more SD of SMI, the prevalence of sarcopenia and SO was 5.1% and 5.1% respectively in men and 14.2% and 12.5% respectively in women. As defined by SMI, subjects with SO had 3 times the risk of metabolic syndrome (OR = 3.03, 95% confidence interval (CI) = 1.26-7.26) and subjects with non-sarcopenic obesity had approximately 2 times the risk of metabolic syndrome (OR = 1.89, 95% CI = 1.18-3.02) compared with normal subjects. 
*Conclusion:* Obese subjects with relative sarcopenia were associated with a greater likelihood for metabolic syndrome. As Koreans were more obese and aging, the prevalence of SO and its impact on health outcomes are estimated to be rapidly grow. Further research is requested to establish the definition, cause and consequences of SO.
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Hybrid organic-inorganic light-emitting electrochemical cells using fluorescent polymer and ionic liquid blend as an active layer

We demonstrate enhanced device performance by using a blend of emissive polymer and mobile ionic liquid molecules in hybrid organic-inorganic polymeric light-emitting electrochemical cells with high air stability. The mobile anions and cations redistributed near each electrode/active layer interface make ohmic contacts, thereby enhancing current density and electroluminescence efficiency at relatively low operating voltage.open12