The distribution of carriers of different genotypes of COMT, DAT and DRD2 genes in the sample.

<p> = total number of subjects.</p

Duration discrimination paradigm.

<p>(Adapted from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0012650#pone.0012650-Sano1" target="_blank">[37]</a>.)</p

5-HTT, MAOA and 5-HT2a genotypes and duration representation parameters: PSE, RSE and .

<p> = total number of subjects.</p

fMRI group results of the reproduction phase (computed in Lipsia).

<p>*significant at p<0.05 corrected.</p

Mean interval reproductions.

<p>Mean reproduced durations ± SD for all subjects in the OFF (blue) and ON (green) conditions. Direct comparison between the ON and OFF condition was significant only for the 16.8 s interval (paired t-test, p<0.05). Dots inside of the bars represent missed responses for each interval and condition.</p

Time-course plots of the activity in the precuneus (coordinates 4 −62 26) according to the phase and interval duration.

<p>Activity is plotted during encoding short (upper left), encoding long (lower left), reproduction short (upper right) and reproduction long (lower right) conditions. Group means ± standard error of mean (SEM) for OFF (blue) and ON (green) conditions are depicted. Time points, where at least 3 observations per subject and 6 subjects per time point were not available, were excluded. Therefore encoding of short intervals was followed up to 10 seconds, encoding of long intervals up to 14 seconds, reproduction of short intervals up to 8 seconds and reproduction of long intervals up to 12 seconds. Bars in the upper right corner of each graph represent overall contrast estimate mean ± SD for each condition. The comparison between OFF and ON conditions yielded significant differences only for the reproduction of long intervals (marked with ***, paired t-test p<0.001).</p

Time-course plot of the activity in precuneus (coordinates 4 −62 26) during the reproduction phase.

<p>Each dot represents mean activity in a time point for all trials of one subject in OFF (blue) and ON (green) conditions. Lines connect group means for all subjects. For better clarity, dots are jittered.</p

Area activated in the reproduction phase, ON>OFF.

<p>On the left, results of the second-level group analysis (p<0.05 corrected) are rendered to a structural MRI image using vlrender function from Lipsia package. On the right, the mean contrast estimate plots ± SD in the right precuneus (coordinates 4 −62 26) during encoding (left) and reproduction (right) phases. There was deactivation of the precuneus found in all four conditions (encoding ON, encoding OFF, reproduction ON, reproduction OFF). Comparison between OFF (blue) and ON (green) conditions was significant only during the reproduction phase (paired t-test, p<0.001), when deactivation was more marked in the OFF condition.</p