Experiences of the Support Designs in the Two Large Underground Openings in India

Support requirements for two caverns arc worked out by empirical and the numerical approaches. The adequacy of the shotcrete-rock bolt support system is monitored by measuring the deformations of caverns walls and roof. The measurements are compared with the results obtained from the numerical approach. Brief geology, the supports, and the results of performance monitoring are presented in the paper

Squeezing Problems in Indian Tunnels

Case histories of three Indian tunnels indicate that squeezing conditions are created due to plastic flow of rock masses under the influence of high cover pressures. These examples emphasize that a tunnel experiencing squeezing conditions must be allowed to deform to optimize support costs and avoid delays. Allowance for desirable tunnel deformations must, therefore, be made while planning the size of excavation. Field data has shown that a flexible support system of compressible backfill and steel ribs may be used as an alternative to shotcrete support which is unpractical in Indian tunnels excavated largely by conventional methods. Instrumentation indicates that large broken zones are associated with late stabilization and that the coefficient of volumetric expansion of failed rock masses is significantly lower than believed so far. Comparison of measured rock pressures with those estimated from available methods shows that the elasto-plastic theory may provide reliable predictions provided that the strength parameters of rock masses are known precisely

Neuromedin U partially mediates leptin-induced hypothalamo-pituitary adrenal (HPA) stimulation and has a physiological role in the regulation of the HPA axis in the rat.

Intracerebroventricular (ICV) administration of the hypothalamic neuropeptide neuromedin U (NMU) or the adipostat hormone leptin increases plasma ACTH and corticosterone. The relationship between leptin and NMU in the regulation of the hypothalamo-pituitary adrenal (HPA) axis is currently unknown. In this study, leptin (1 nM) significantly increased the release of CRH from ex vivo hypothalamic explants by 207 ± 8.4% (P < 0.05 vs. basal), an effect blocked by the administration of anti-NMU IgG. The ICV administration of leptin (10 μg, 0.625 nmol) increased plasma ACTH and corticosterone 20 min after injection [plasma ACTH (picograms per milliliter): vehicle, 63 ± 20, leptin, 135 ± 36, P < 0.05; plasma corticosterone (nanograms per milliliter): vehicle, 285 ± 39, leptin, 452 ± 44, P < 0.01]. These effects were partially attenuated by the prior administration of anti-NMU IgG. Peripheral leptin also stimulated ACTH release, an effect attenuated by prior ICV administration of anti-NMU IgG. We examined the diurnal pattern of hypothalamic NMU mRNA expression and peptide content, plasma leptin, and plasma corticosterone. The diurnal changes in hypothalamic NMU mRNA expression were positively correlated with hypothalamic NMU peptide content, plasma corticosterone, and plasma leptin. The ICV administration of anti-NMU IgG significantly attenuated the dark phase rise in corticosterone [corticosterone (nanograms per milliliter): vehicle, 493 ± 38; NMU IgG, 342 ± 47 (P < 0.05)]. These studies suggest that NMU may play a role in the regulation of the HPA axis and partially mediate leptin-induced HPA stimulation. Copyright © 2006 by The Endocrine Society

Emergency Data Activation

EDA (Emergency Data Activation) is an application which give emergency data(internet) to its users for their usage for this users have to performs certain procedure embedded in our application

Endomembrane PtdIns(3,4,5)P3 activates the PI3K–Akt pathway

PKB/Akt activation is a common step in tumour growth, proliferation and survival. Akt activation is understood to occur at the plasma membrane of cells in response to growth factor stimulation and local production of the phosphoinositide lipid phosphatidylinositol (3,4,5)- trisphosphate [PtdIns(3,4,5)P3] following phosphoinositide 3-kinase (PI3K) activation. The metabolism and turnover of phosphoinositides is complex - they act as signalling molecules as well as structural components of biological membranes. The localisation and significance of internal pools of PtdIns(3,4,5)P3 has long been speculated upon. By using transfected and recombinant protein probes for PtdIns(3,4,5)P3, we show that PtdIns(3,4,5)P3 is enriched in the nuclear envelope and early endosomes. By exploiting an inducible dimerisation device to recruit Akt to these compartments, we demonstrate that Akt can be locally activated in a PtdIns(3,4,5)P3- dependent manner and has the potential to phosphorylate compartmentally localised downstream substrates. This could be an important mechanism to regulate Akt isoform substrate specificity or influence the timing and duration of PI3K pathway signalling. Defects in phosphoinositide metabolism and localisation are known to contribute to cancer, suggesting that interactions at subcellular compartments might be worthwhile targets for therapeutic intervention

Assessing the prevalence and potential drivers of food insecurity and the relationship with mental wellbeing in UK university students: A cross-sectional study

Food insecurity (FI) among university students in the United States has been associated with poor mental wellbeing, but very little is known about the rela-tionship between FI and mental wellbeing in the UK university population. Here we examined the prevalence of FI, determined potential drivers for it and its relationship with mental wellbeing and coping ability. Students studying at UK universities (n= 289) completed an online self-reported questionnaire to obtain socio-economic characteristics including financial status, FI status (Household Food Insecurity Access scale), mental wellbeing (Warwick-Edinburgh Mental Wellbeing Scale) and coping ability (coping flexibility scale). FI was observed in 28% of the participants and was associated with financial independence, run-ning out of money, borrowing money and lacking confidence to purchase healthy foods (p< 0.05). Although we cannot determine directionality, logistic regression analysis revealed those who were judged as FI were more likely to shop often (OR= 3.139 95% CI 1.533–6.429), never snacked between meals (OR = 4.261 95% CI 1.309–13.875) and the amount of food purchased was affected by perceptions of the price of food in general (OR = 2.954 95% CI 1.675–5.210). Financial instability and the inability to access nutritious food may contribute to the decrease in mental wellbeing (p< 0.01) and lower ability to cope with stress-ful situations (p< 0.01) in food-insecure students although the direction of these relationships cannot be determined from this cross-sectional study. This study has identified that there is a need to develop appropriate strategies to combat FI in university students and to improve mental health

Response of dust on thermal emission spectra observed by Planetary Fourier3 Spectrometer (PFS) on-board Mars Express (MEX)

The thermal emission spectra have provided many useful insights about the Martian atmosphere and surface. The interpretation of the thermal emission spectra can give us information about atmospheric temperature, pressure, mineralogy and presence of atmospheric constituents including their isotopes. In the present work, we have analysed the thermal emission data for dust storm season on Mars. The signature of dust in the thermal emission spectra for Martian Year (MY) 28 confirms presence (Ls=280o and 300o) and absence (Ls=240o and 320o) of the dust storm at latitude range 0o-10oS, 10o-20oS and 20o-30oS. We have compared our results with earlier mission data with thermal emission measurements made by Planetary Fourier Spectrometer (PFS) on-board Mars Express (MEX) between wave numbers 250-1400 cm-1. We have observed features at wave numbers 600-750 cm-1 and 900-1200 cm-1 due to absorptions by CO2 and dust respectively. We have obtained brightness temperatures from thermal emission spectra by inverting the Planck function. The maximum brightness temperature ~280 K is measured at Ls=240o when Mars received a large amount of solar radiation at perihelion. The minimum brightness temperature ~ 220o K is observed at Ls=320o in the absence of dust storm. In presence of dust storm thermal emission spectra and brightness  temperatures are reduced by factors of ~ 3.0 and ~1.3 respectively between wave numbers 900-1200 cm-1 in comparison to that observed in absence of dust storm

Single Center Experience of Sirolimus Therapy in Head and Neck Low-flow Vascular Malformations

OBJECTIVE: Recently, studies have shown that sirolimus is clinically efficacious in the treatment of some low-flow vascular malformations (LFVM). This study aimed to assess the efficacy and safety of sirolimus in treating complex head and neck (H&N) LFVM that were challenging and/or refractory to standard treatment. METHODS: Each patient had baseline and 6-months assessments consisting of clinical history and examination, quality of life (QoL) questionnaires, laboratory investigations, MRI and medical photography. Patients were followed up 1-week and then 1-monthly for 6-months. Wilcoxon signed-rank test was used to compare pre-and 6-months treatment in all 8 domains of RAND 36-Item Short Form Health Survey (SF-36), hospital anxiety and depression scale (HADS), and visual analog score for pain (VAS-P). P < 0.05 was considered significant. RESULTS: Seven patients (median age 43 years, range 23-65 years) were recruited. Six patients completed the six-months course of therapy with 1 patient withdrawing due to intolerable side effects. All six patients reported reduction of swelling with and without other symptom improvement related to the vascular malformations while on treatment. However, at 1-month review after discontinuation of sirolimus, 5 patients reported return of initial symptoms. Overall, patients demonstrated an improvement in QoL six-months treatment but there was no statistical significance (P > 0.05) in all 8 domains of SF-36, HADS and VAS-P. Five patients demonstrated a minimum 10% decrease in lesion size six-months treatment (median 21%, range 13-40%). A Wilcoxon signed-rank test showed that sirolimus treatment did elicit a statistically significant change in lesion size in either direction (Z = -1.992, P = 0.046). The most common side effects found were dyslipidaemia (n-4) and mouth ulcers (n = 2). CONCLUSIONS: In our preliminary experience, sirolimus is effective and safe in treating patients with complex H&N LFVM. This provides an alternative treatment where standard treatment is challenging and/or refractory