PCR gene targets and sources from which the primers were obtained.

<p>This multiplex nested PCR was performed in all samples independently of any diagnostic test carried out by the referring hospital.</p><p>PCR gene targets and sources from which the primers were obtained.</p

Pathogen prevalence in the main and replication cohorts shown as number detected in nasopharyngeal samples considering the age of the children.

<p>Only the more prevalent viruses are presented.</p

Associations among respiratory pathogens in hospitalized children in the GENDRES and UK cohorts.

<p>Associations among respiratory pathogens in hospitalized children in the GENDRES and UK cohorts.</p

Comparison of virus and disease severity of the main cohort considering the virus as single pathogen or as co-infection in the sample.

<p>Different statistical models were considered to study the bivariate association between the variables depending on the dependent variable. A binary logistic model was used for the binary variables oxygen needed and respiratory support needed, and a negative binomial regression model for counted data (hospital stay length). Data are presented as OR (confidence interval 95%) and the level of statistical significance was set at 0.05.</p

Influence of bacterial superinfection, pneumococcal vaccine and the presence of viral co-infection on disease severity of children with ARI, according to oxygen and respiratory support requirement, clinical scales, hospital stay length and PICU admission.

<p>Data are shown as OR (95% CI) for both main cohort and replication cohort. A binary logistic model was used for the binary variables (co-infection status, oxygen requirements, respiratory support needed and PICU admission), linear model for continuous variables (Wood-Downes Score and the GENVIP score) and negative binomial regression model for counted data (number of days since admission).</p

Description of the characteristics of the two cohorts analyzed: the GENDRES cohort and the UK cohort.

<p><i>P</i>-value results from the comparison between both cohorts. A <i>P</i>-value < 0.05 was considered significant.</p

Relationship between demographic and clinical variables with mono-infection and co-infection is shown for both GENDRES and UK cohort.

<p>The correlation was analysed using simple logistic regression. Data are presented as OR (95% confidence interval) and <i>P</i>-value. The characteristics of the two cohorts analyzed were compared and when P-value results were significant when different: the GENDRES cohort and the UK cohort. <i>P</i>-value results from the comparison between both cohorts. A <i>P</i>-value < 0.005 was considered significant.</p

Additional file 4: of Hypothermia for encephalopathy in low and middle-income countries (HELIX): study protocol for a randomised controlled trial

SPIRIT checklist. (PDF 77 kb

Additional file 1: of Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS)

Figures S1-S4, Tables S1-S4, and the EUCLIDS consortium author list. (DOCX 145 kb

Variation in the use of POCTs between the included countries expressed as median odds ratio (MORs).

GAS: Group A streptococcus; RSV: Respiratory syncytial virus; FBC/WBC: Full blood count/White blood count; CRP: C-reactive protein; PCT: Procalcitonin. A: Country MORs for the use of POCTs in primary care. B: Country MORs for the use of POCTs in hospitals. MOR>1 indicate variation in the use of POCTs across countries.</p