Platelet activation in the postoperative period after lung transplantation

Objective During lung transplantation, cells in the pulmonary parenchyma are subjected to ischemia, hypothermic storage, and reperfusion injury. Platelets, whose granular contents include adhesion receptors, chemokines, and coactivating substances that activate inflammatory and coagulant cascades, likely play a critical role in the lung allograft response to ischemia and reperfusion. The platelet response to the pulmonary allograft, however, has never been studied. Here we report significant platelet activation immediately after lung transplantation. Methods We performed a prospective cohort study comparing markers of platelet activation in patients undergoing lung transplantation and patients undergoing nontransplant thoracotomy. Plasma levels of soluble P-selectin, soluble CD40 ligand, and platelet–leukocyte conjugates were measured before surgery, after skin closure, and at 6 postoperative hours. Results Both soluble P-selectin and soluble CD40 ligand levels increased significantly after lung transplantation but not after thoracotomy. Additionally, platelet–monocyte conjugate fluorescence was significantly higher after lung transplantation than after thoracotomy alone. Conclusion These findings suggest that platelet activation is significantly increased after lung transplantation beyond that expected from the postoperative state. The increase in circulating platelet–monocyte conjugates suggests an important interaction between platelets and inflammatory cells. Further research should examine whether platelet activation affects early graft function after lung transplantation

Why is Authenticity Associated with Being and Acting Extraverted? Exploring the Mediating Role of Positive Affect

Extraversion is linked to higher levels of authenticity. Why? Across four studies, we examined positive affect as a potential mediator. In Study 1 (N = 205), we tested our mediation model at the trait level. Then, focusing on the within-person state level: Study 2 (N = 97) involved a ten-week lab-based experience sampling protocol; Study 3 (N = 147) involved a preregistered week-long daily-life experience sampling protocol; and Study 4 (N = 129) involved a two-week naturalistic experience sampling protocol. In all four studies, positive affect explained moderate to high proportions of the effects of extraversion on authenticity (Study 1 = 29%, Study 2 = 38%, Study 3 = 87%, Study 4 = 86%). We discuss several theoretical interpretations

How and Why People Want to Be More Moral - Study 2 Preregistration

This project aims to describe how people typically conceptualize moral improvement, to explore people’s beliefs about the process and consequences of moral improvement, and to understand what motivates people to be more moral

How and Why People Want to Be More Moral

What types of moral improvements do people wish to make? Do they hope to become more good, or less bad? Do they wish to be more caring? More honest? More loyal? And why exactly do they want to become more moral? Presumably, most people want to improve their morality because this would benefit others, but is this in fact their primary motivation? Here, we begin to investigate these questions. Across two large, preregistered studies (N = 1,818), participants provided open-ended descriptions of one change they could make in order to become more moral; they then reported their beliefs about and motives for this change. In both studies, people most frequently expressed desires to improve their compassion and more often framed their moral improvement goals in terms of amplifying good behaviors than curbing bad ones. The strongest predictor of moral motivation was the extent to which people believed that making the change would have positive consequences for their own well-being. Together, these studies provide rich descriptive insights into how ordinary people want to be more moral, and show that they are particularly motivated to do so for their own sake

Six-Minute-Walk Distance Predicts Waiting List Survival in Idiopathic Pulmonary Fibrosis

Rationale: Functional studies may be useful to predict survival in idiopathic pulmonary fibrosis (IPF). Various cutoffs of 6-min-walk distance (6MWD) have been suggested to identify patients at a high risk of death