Opulent Operetta and Marvelous Musicals

Program listing performers and works performe

The Measure of Poverty: A Boston Indicators Project Special Report

Examines Boston's poverty rate by race/ethnicity, family structure, education, and geography; income inequality; demand for safety-net programs; and how the high cost of living and budget cuts affect vulnerable households and those below the poverty line

Plant succession on gopher mounds in Western Cascade meadows: consequences for species diversity and heterogeneity

Pocket gophers have the potential to alter the dynamics of grasslands by creating mounds that bury existing vegetation and locally reset succession. Gopher mounds may provide safe sites for less competitive species, potentially increasing both species diversity and vegetation heterogeneity (spatial variation in species composition). We compared species composition, diversity and heterogeneity among gopher mounds of different ages in three montane meadows in the Cascade Range of Oregon. Cover of graminoids and forbs increased with mound age, as did species richness. Contrary to many studies, we found no evidence that mounds provided safe sites for early successional species, despite their abundance in the soil seed bank, or that diversity peaked on intermediate-aged mounds. However, cover of forbs relative to that of graminoids was greater on mounds than in the adjacent meadow. Variation in species composition was also greater within and among mounds than in adjacent patches of undisturbed vegetation, suggesting that these small-scale disturbances increase heterogeneity within meadows

City of Ideas: Reinventing Boston's Innovation Economy: The Boston Indicators Report 2012

Analyzes indicators of the city's economic, social, and technological progress; potential for creating innovative solutions to global and national challenges; and complexities, disparities, and weaknesses in the indicators and innovation economy paradigm

New roles for Fc receptors in neurodegeneration-the impact on immunotherapy for Alzheimer's disease

There are an estimated 18 million Alzheimer's disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need. AD is characterized by episodic memory loss followed by severe cognitive decline and is associated with many neuropathological changes. AD is characterized by deposits of amyloid beta (A?), neurofibrillary tangles, and neuroinflammation. Active immunization or passive immunization against A? leads to the clearance of deposits in transgenic mice expressing human A?. This clearance is associated with reversal of associated cognitive deficits, but these results have not translated to humans, with both active and passive immunotherapy failing to improve memory loss. One explanation for these observations is that certain anti-A? antibodies mediate damage to the cerebral vasculature limiting the top dose and potentially reducing efficacy. Fc gamma receptors (Fc?R) are a family of immunoglobulin-like receptors which bind to the Fc portion of IgG, and mediate the response of effector cells to immune complexes. Data from both mouse and human studies suggest that cross-linking Fc?R by therapeutic antibodies and the subsequent pro-inflammatory response mediates the vascular side effects seen following immunotherapy. Increasing evidence is emerging that Fc?R expression on CNS resident cells, including microglia and neurons, is increased during aging and functionally involved in the pathogenesis of age-related neurodegenerative diseases. Therefore, we propose that increased expression and ligation of Fc?R in the CNS, either by endogenous IgG or therapeutic antibodies, has the potential to induce vascular damage and exacerbate neurodegeneration. To produce safe and effective immunotherapies for AD and other neurodegenerative diseases it will be vital to understand the role of Fc?R in the healthy and diseased brain. Here we review the literature on Fc?R expression, function and proposed roles in multiple age-related neurological diseases. Lessons can be learnt from therapeutic antibodies used for the treatment of cancer where antibodies have been engineered for optimal efficacy

Fatally Injured Pedestrians and Bicyclists in the United States with High Blood Alcohol Concentrations

More than one-third of pedestrians and one-fifth of bicyclists killed in crashes in 2014 were impaired by alcohol, but scant attention has been paid to the problem. This omission contrasts starkly with the many successful policies that have reduced impaired driving, a new Institute study notes.The study looked at fatalities of passenger vehicle drivers, pedestrians and bicyclists 16 and older from 1982 to 2014. Using a federal database, IIHS researchers looked at the characteristics of those crashes and trends over time. They found that the percentage of fatally injured pedestrians and bicyclists 16 and older who were impaired has fallen over the decades, but not as dramatically as the percentage of impaired drivers

Pattern Selection in the Complex Ginzburg-Landau Equation with Multi-Resonant Forcing

We study the excitation of spatial patterns by resonant, multi-frequency forcing in systems undergoing a Hopf bifurcation to spatially homogeneous oscillations. Using weakly nonlinear analysis we show that for small amplitudes only stripe or hexagon patterns are linearly stable, whereas square patterns and patterns involving more than three modes are unstable. In the case of hexagon patterns up- and down-hexagons can be simultaneously stable. The third-order, weakly nonlinear analysis predicts stable square patterns and super-hexagons for larger amplitudes. Direct simulations show, however, that in this regime the third-order weakly nonlinear analysis is insufficient, and these patterns are, in fact unstable

Non-cognitive Skills and the Gender Disparities in Test Scores and Teacher Assessments: Evidence from Primary School

We extend the analysis of early-emerging gender differences in academic achievement to include both (objective) test scores and (subjective) teacher assessments. Using data from the 1998-99 ECLS-K cohort, we show that the grades awarded by teachers are not aligned with test scores, with the disparities in grading exceeding those in testing outcomes and uniformly favoring girls, and that the misalignment of grades and test scores can be linked to gender differences in non-cognitive development. Girls in every racial category outperform boys on reading tests and the differences are statistically significant in every case except for black fifth-graders. Boys score at least as well on math and science tests as girls, with the strongest evidence of a gender gap appearing among whites. However, boys in all racial categories across all subject areas are not represented in grade distributions where their test scores would predict. Even those boys who perform equally as well as girls on reading, math and science tests are nevertheless graded less favorably by their teachers, but this less favorable treatment essentially vanishes when non-cognitive skills are taken into account. White boys who perform on par with white girls on these subject-area tests and exhibit the same non-cognitive skill level are graded similarly. For some specifications there is evidence of a grade "bonus" for white boys with test scores and behavior like their girl counterparts. While the evidence is a little weaker for blacks and Hispanics, the message is essentially the same.gender differences, test scores, grades, educational attainment

Condom use and incident sexually transmitted infection after initiation of long-acting reversible contraception

Background Use of more effective contraception may lead to less condom use and increased incidence of sexually transmitted infection. Objective The objective of this study was to compare changes in condom use and incidence of sexually transmitted infection acquisition among new initiators of long-acting reversible contraceptives to those initiating non-long-acting reversible contraceptive methods. Study Design This is a secondary analysis of the Contraceptive CHOICE Project. We included 2 sample populations of 12-month continuous contraceptive users. The first included users with complete condom data (baseline, and 3, 6, and 12 months) (long-acting reversible contraceptive users: N = 2371; other methods: N = 575). The second included users with 12-month sexually transmitted infection data (long-acting reversible contraceptive users: N = 2102; other methods: N = 592). Self-reported condom use was assessed at baseline and at 3, 6, and 12 months following enrollment. Changes in condom use and incident sexually transmitted infection rates were compared using χ2 tests. Risk factors for sexually transmitted infection acquisition were identified using multivariable logistic regression. Results Few participants in either group reported consistent condom use across all survey time points and with all partners (long-acting reversible contraceptive users: 5.2%; other methods: 11.3%; P < .001). There was no difference in change of condom use at 3, 6, and 12 months compared to baseline condom use regardless of method type (P = .65). A total of 94 incident sexually transmitted infections were documented, with long-acting reversible contraceptive users accounting for a higher proportion (3.9% vs 2.0%; P = .03). Initiation of a long-acting reversible contraceptive method was associated with increased sexually transmitted infection incidence (odds ratio, 2.0; 95% confidence ratio, 1.07–3.72). Conclusion Long-acting reversible contraceptive initiators reported lower rates of consistent condom use, but did not demonstrate a change in condom use when compared to preinitiation behaviors. Long-acting reversible contraceptive users were more likely to acquire a sexually transmitted infection in the 12 months following initiation