Increasing thyroid cancer risk: Link to hydrogen iodate?

The robust oxidative capacity in hydrogen iodate can lead to the formation of oxidized molecules with carbonyl oxygen or hydroxyl oxygen gathering protons via hydrogen bonding, augmenting the generation of mutagenic strong acids such as HCl

Can starch-based diet or sugar water put an end to the COVID-19 pandemic?

High valine plus glycine content is a feature of the proteins in SARS-CoV-2 and SARS viruses, and it causes the generation of aggregates between proteins and insoluble calcium salts via secondary chemical bonding. Starch-based diet or sugar water with adequate vitamins can go for many days without the generation of essential amino acids such as valine, creating bottlenecks in virion production in human body. Despite its potential carcinogenicity, modest lysine supplement can be favorable as lysine rich proteins gather chloride and solubilize stressful, insoluble and stiff calcium oxalate and calcium phosphate

Defensive reactions against intrinsic stresses

Drug development for Alzheimer’s disease faces immense challenge with hundreds of failed clinical trials, and the amyloid β-protein- or Aβ-centric hypothesis is under heated debate. Cells react to environmental cues and stresses to better adapt to external milieu. However, how various organisms respond to intrinsic stresses is not fully explored. Here we propose that cells initiate a defensive response toward intrinsic stress which can be positive, negative or mixed on the host. Experiments on cellular responses to endogenous stresses could yield insight into this hypothesis. The interrogation on hydrogen bonding, secondary chemical bonding to divalent cations and their antagonism can advance biochemical understandings in this regard. Pertinent study will further our knowledge on the etiology of human disorders

Food regimen to treat heart disease, Alzheimer’s disease and amyotrophic lateral sclerosis

Carbohydrate-based diet such as rice does not produce much essential amino acids and creates bottlenecks in protein synthesis, consequently reducing the cellular levels of causative factors. Modest lysine supplement combined with food rich in weak organic acids can change the proteome and solubilize insoluble and stiff salts. Warm temperature minimizes the generation of oxalate. Integration of these strategies can be favorable in the treatment of numerous diseases but cancer. The aforementioned diet may be suitable for human subpopulation with primary constipation, one of the manifestations of many disorders such as heart disease, Alzheimer’s disease, amyotrophic lateral sclerosis, muscular dystrophy, Rabies, Stiff Person Syndrome, Mad Cow disease, paralysis and some form of depression

Elimination of diarrhea or bleeding could be a sign of successful cancer control for long-term survival

Cancer patients often exhibit diarrhea or bleeding before the onset of malignancies. The control of such symptoms with plant-based diet and calcium tablets could eliminate neoplasm risk and prevent tumorigenesis. It may also extend the lifespan of cancer sufferers. To identify cancer-patients-friendly food, a rule of the thumb is that those food which render you loose- and watery-stool or bleeding could be slightly carcinogenic

Earth’s self-rotation causes water going down a drain to spin differently in Southern and Northern hemispheres

In Northern hemisphere, the Earth surface going northward is more tilted relative to the Sun, so the vertical component of the virtually constant solar pull turns smaller as mass position shifts northward, and it cancels out less downward vast gravity of the Earth. This in combination with Earth’s self-rotation and lunar pull generates the phenomena of water going down a drain to swirl differently in the Southern and Northern hemispheres

Aging and age-related diseases

Various mechanisms have been proposed, and a molecular perspective is much awaited to account for the observed phenomena regarding aging and death. Valine and glycine are overrepresented in numerous causative factors of heart disease and Alzheimer’s disease, as well as in proteins of SARS-CoV-2 strains causing the current pandemic. Both amino acids have long carbonyl bond lengths and thus possess affinities to divalent cations, promoting the formation of insoluble salts. The insoluble and stiff calcium oxalate is stressful to cells and triggers cell senescence. Consequently valine plus glycine content can serve as a ticking aging clock as longevity genes generally encode proteins rich in valine plus glycine. Given the common characteristics of the longevity gene products, aging process may be intervened by diet, exercise and lifestyle

Why there is a large gene set associated with human cognitive function?

Despite substantial progress in the field of cognitive science, no theories can fully account for large number of genes found to be associated with human intelligence. According to an initial survey on genes with more than 1 exonic nonsynonymous SNPs, features with the overrepresentation of valine plus glycine or rich basic amino acids or both were identified. High valine plus glycine is also a hallmark of the causative factors of Alzheimer’s disease and dementia, and the two amino acids may boast robust calcium affinity. Inverse association between cancer and Alzheimer’s disease has been discovered before. Previous study indicated that highly educated males had greater risk of glioma compared to men with primary education. The Krebs cycle churns out large amount of protons and organic acids. Strong acids are mutagenic and carcinogenic, yet they can solubilize insoluble and stiff calcium oxalate which is implicated in numerous age-related disorders such as Alzheimer’s disease, dementia and heart disease. And vice versa, insoluble salts antagonize strong acids chemically. Therefore, cognitive function may be subjected to the influence of the amino acids in proteins which possess hydrogen bonding or secondary chemical bonding to non-proton cations, in addition to ionic bonds and other chemical forces

Why probiotics yogurt is beneficial to HIV/AIDS patients?

AIDS patients often display symptom of diarrhea, an indication of hydrogen bonding mediated by viral proteins with amino acids capable of secondary chemical bonding. With hydrogen bonding to protons, local strong acids such as HCl could build up, giving rise to proton stress which may damage cells or trigger tumorigenesis. Weak organic acids counteract strong acids and attenuate proton stress. The integration of antiviral medicine with probiotics could yield favorable outcomes to AIDS patients and meanwhile reduce cancer incidences

Mutagenesis by RNA-containing telomerase holoenzyme complex or R-loops: a missing piece of the puzzle

Overexpression of telomerase has been demonstrated to substantially extend the lifespan of mice. However, this treatment has a negative side, namely the increase of cancer risk. Most components of the telomerase holoenzyme complex possess high basic amino acid content, potentially attracting anions and enhancing the formation of mutagenic and carcinogenic HCl. Weak organic acids antagonize strong acids, and thus can raise cellular pH and modify the microenvironment. R-loops are hybrid DNA and RNA structures, and trigger DNA replication stress and genome instability. RNA has one additional hydroxyl oxygen atom on ribose compared with DNA, and single stranded DNA harbors bases free of hydrogen bonding. These two factors can enhance the buildup of protons via hydrogen bonding and the local formation of HCl. Strong acids generated can augment DNA mutagenesis, and enhance DNA excision, repair and formation of double stranded breaks. Neoplasm must be addressed before lifespan extension remedies via telomerase are ready for use