Clinical characteristics of stage II and III CC patients (n = 284).

<p>Clinical characteristics of stage II and III CC patients (n = 284).</p

Box plots of the association between gene expression level for <i>ACSL1</i> and genotype for rs8086 SNP located on the 3’-UTR region.

<p>The box plots show how the <i>ACSL1</i> expression values are distributed for each genotype from the Additive, Dominant and Recessive model of inheritance for <i>ACSL1</i> rs8086 SNP in stage II and III CC patients. The p-values were calculated using the non-parametric Krustal-Wallis and Mann-Whitney tests, respectively. The line within the box indicate the median of level expression. The gene expression data were normalized using the geometric mean of the internal control genes <i>GAPDH</i> and <i>B2M</i>.</p

Association between <i>ACSL1</i> and <i>SCD</i> gene expression level and the different genotypes from the diverse models of inheritance for <i>ACSL1</i> rs8086 and <i>SCD</i> rs522951 SNPs in stage II and III CC patients.

<p>Association between <i>ACSL1</i> and <i>SCD</i> gene expression level and the different genotypes from the diverse models of inheritance for <i>ACSL1</i> rs8086 and <i>SCD</i> rs522951 SNPs in stage II and III CC patients.</p

Kaplan-Meier curve of <i>ACSL1</i> SNP rs8086 and <i>SCD</i> SNP rs522951 on DFS for stage II and III CC patients in a recessive and dominant model of inheritance, respectively.

<p>P-value was calculated by Log-rank test.</p

Main effect <i>p-values</i> for bladder cancer risk (overall and for each subphenotype) for each tag-SNP under the additive mode of inheritance.

<p>A SNP <i>p-value</i> above the red line is considered as associated with the phenotype after multiple testing correction by Bonferroni (4.2 for main effects and 3.6 for subtypes). All models are adjusted for age, gender, region and cigarette smoking status.</p

Demographics and smoking status of patients included in the study.

1<p><i>p-value</i> from Pearson's χ² test for association.</p

SNPs in <i>TP53</i> and bladder cancer risk.

<p><i>Repr. (%)</i>,percentage reproducibility assessing the robustness of each SNP by LASSO.</p><p>AA, Aa and aa represent common-homozygotes, heterozygotes and rare-allele homozygotes, respectively.</p><p>OR, odds ratio; CI, confidence interval; OR(Aa) and OR(aa) were estimated relative to genotype AA.</p>1<p>Arg72Pro polymorphism.</p><p>All models were adjusted for age, gender, region and cigarette smoking status.</p

Significant SNPs at α = 0.05 in the logistic regression main effect models.

<p><i>MAF(a)</i>, minor allele frequency); <i>pHWE</i>, <i>p-value</i> from the Hardy Weinberg equilibrium test; <i>MOI</i>, Mode of Inheritance.</p><p><i>Repr. (%)</i>, percentage reproducibility assessing the robustness of each SNP by LASSO.</p><p>All models are adjusted for age, gender, region and smoking status.</p><p>Odd ratio and 95%CI under the model of inheritance that provided the lowest <i>p-value</i>, and percentage reproducibility from LASSO under the additive mode of inheritance.</p