Additional file 1 of Label noise in subtype discrimination of class C G protein-coupled receptors: A systematic approach to the analysis of classification errors

This is a csv format file containing the table of 52 frequently misclassified sequences that were common to all four data transformations, as described in the Results section of the main text. It includes the following columns: GPCRDB identifier, GPCRDB true class, and predicted class for, in turn, the AAC, Digram, ACC and PDBT transformations. A strong agreement on the most-often predicted class C GPCR subtypes can be observed. (XLS 22 Kb

Additional file 1: Table S1. of GNAO1 encephalopathy: further delineation of a severe neurodevelopmental syndrome affecting females

Sequence alignment as calculated by NCBI-BLAST between human Gαo (Query) and mouse Gαo (Sbjct, PDB id: 3C7K). (DOC 69 kb

Flow diagram of the study.

<p>^aDetailed description in Zock et al. 2007. ^bDetailed description in Rodriguez-Trigo et al. 2010.</p

Chromosome damage in exposed and non-exposed individuals from P2y and P6y genotoxic studies and in control individuals.

<p>Chromosome damage in exposed and non-exposed individuals from P2y and P6y genotoxic studies and in control individuals.</p

Type of spontaneous chromosome damage on the most affected bands in exposed individuals two and six years after oil spill exposure.

<p>Type of spontaneous chromosome damage on the most affected bands in exposed individuals two and six years after oil spill exposure.</p

Chromosomal damage induced by aphidicolin in exposed and non-exposed individuals to oil six years after oil exposure.

<p>Chromosomal damage induced by aphidicolin in exposed and non-exposed individuals to oil six years after oil exposure.</p

Flow diagram of the study.

<p>^aDetailed description in 22, ^bDetailed description in 13, ^cDetailed description in15, ^dDetailed description in14, ^eDetailed description in 23, ^fDetailed description in16.</p

Chromosome bands most affected by spontaneous breakage in exposed and non-exposed individuals six years after oil exposure.

<p>Chromosome bands most affected by spontaneous breakage in exposed and non-exposed individuals six years after oil exposure.</p

Distribution of breakpoints observed in lymphocytes metaphases from exposed to oil (right) and non-exposed (left) individuals in the human ideogram (400-band resolution).

<p>The most affected bands only in exposed are indicated by arrows.</p

Distribution of chromosome breakpoints observed in exposed (right) and non-exposed individuals (left) in the human ideogram (400-band resolution).

<p>The most affected bands using the FSM statistical method are indicated by red arrows, and when using another statistical method that takes into account the relative length of chromosomal bands, by black arrows. </p