Additional file 6: of Improved empirical antibiotic treatment of sepsis after an educational intervention: the ABISS-Edusepsis study

Table S4. Compliance with process-of-care measurements in the long-term cohort. (DOC 44 kb

Additional file 1: of Improved empirical antibiotic treatment of sepsis after an educational intervention: the ABISS-Edusepsis study

Appendix 1. Appendix describing in detail the study design, the approach to data collection, and the quality-control measures to ensure data reliability. (DOC 27 kb

Additional file 4: of Improved empirical antibiotic treatment of sepsis after an educational intervention: the ABISS-Edusepsis study

Table S2. Segmented regression model for time in hours to first antibiotic. (DOC 29 kb

Additional file 7: of Improved empirical antibiotic treatment of sepsis after an educational intervention: the ABISS-Edusepsis study

Table S5. Outcome measurements in the long-term cohort. (DOC 31 kb

Wedelia prostrata Hemsl.

原著和名: ハマグルマ科名: キク科 = Compositae採集地: 高知県 高知市 浦戸 (土佐 高知市 浦戸)採集日: 1984/9/10採集者: 萩庭丈壽整理番号: JH031170国立科学博物館整理番号: TNS-VS-98117

Additional file 1: of Neurally adjusted ventilatory assist in patients with acute respiratory failure: study protocol for a randomized controlled trial

Approval of the referral Ethics Committee and the Institutional Review Boards (IRB) of all participating hospitals. (PDF 4.14 mb

MOESM1 of The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure

Additional file 1. Mean survival time (days) in the SOFA <8 group based on immunoglobulin thresholds. Differences between groups were assessed using the log-rank test. Δ (days) represents [(mean survival time in patients with levels of immunoglobulin above the threshold) – (mean survival time in patients with levels of immunoglobulin below the threshold)]. Time was censored at 28 days following ICU admissio

Additional file 1 of A genome-wide association study of survival in patients with sepsis

Additional file 1. Supplementary methods, figures, and tables.The supplementary methods include a description of the GEN-SEP and MESSI study populations, genotyping and quality control, more details of the genome-wide association study of 28-day sepsis survival and the index event bias assessment, tools for the annotation of the functional effects of the sentinel variants and the gene expression of related genes, the association of polygenic risks of sepsis with the 28-day sepsis survival, the replication of genes from previous sepsis mortality GWAS, and related references. The supplementary figures include a principal component analysis, the quantile-quantile plot of the GWAS, regional plots for the genome-wide significant variants, Kaplan-Meier 28-day survival plots, a manhattan plot of sepsis 28-day survival association study results in the HLA region, a plot of expression of related genes across cell types, a boxplot of SAMD9 gene expression values in GSE54514 and GSE65682, a boxplot of SAMD9 gene expression values in GSE32707, and polygenic risk score (PRS) model fitting. The supplementary tables show the relevant demographic and clinical features of cases and controls used for the GWAS of sepsis risk and for the GEN-SEP patients, the list of previous candidate genes associated with sepsis risk, the prioritized independent SNPs, the index bias event results, the association results with 28-day mortality and the percentage of variation explained by the sentinel SNPs by separate or as part of a PRS, the association results of the sentinel variants from other sepsis mortality GWAS studies, the nominally significant results for the classical HLA alleles and amino acids, and the functional assessment of variants associated with 28-day sepsis survival