Representative Quotations in Key Subject Areas.

<p>Representative Quotations in Key Subject Areas.</p

Examples of adequate and inadequate disclosure.

<p>Examples of adequate and inadequate disclosure.</p

Authors’ evaluation of physician-centered strategies to promote generic drug and follow-on biologic prescribing

<p>^* Pending further evidence.</p><p><a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001802#t002fn001" target="_blank">^*</a></p

Approved follow-on biologics in the EU.

<p>Approved follow-on biologics in the EU.</p

Effect of antidepressant medication use during pregnancy on preterm birth: meta-analysis results.

(1)<p>Typically 1st trimester; some women continued during pregnancy, others discontinued.</p>(2)<p>Typically 3^rd trimester.</p>(3)<p>Factors varied between studies, but typically included maternal age, smoking, alcohol use, parity, and history of prematurity or miscarriage.</p>(4)<p>Values of I² are percentages (% of variance explained). 95% uncertainty intervals are calculated as proposed by Higgins and Thompson <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0092778#pone.0092778-Higgins1" target="_blank">[89]</a>.</p

Counts and proportions of articles with adequate disclosure, by author.

<p>Each vertical line is a unique author, and the y-axis shows the number of articles published by that author. The extent of the vertical line above or below zero represents the frequency of adequate and inadequate disclosure for each author.</p

Study-specific and pooled odds ratio estimates for antidepressant medication during pregnancy and preterm birth.

<p>Studies that did not adjust for other risk factors.</p

Adjusted study-specific and pooled odds ratio estimates for antidepressant medication during pregnancy and preterm birth.

<p>Subset of studies that account for the underlying psychiatric illness.</p

Sensitivity analysis of residual confounding (Rule-out approach).

<p>Example for estimated OR = 1.61 (depression adjusted point estimate) and OR = 1.26 (lower 95% bound of depression adjusted estimate) for different levels of confounder prevalence (▪ P_c = 0.05, OR = 1.61; •P_c = 0.25, OR = 1.61; □ P_c = 0.05, OR = 1.26; ○P_c = 0.25, OR = 1.26). Each line splits the area into two. The upper right area represents all combinations of OR_EC and RR_CD that would create confounding by an unmeasured factor strong enough to move the point estimate of OR to the null (OR = 1) or beyond. The area to the lower left represents all parameter combinations that would not be able to move the estimated OR to the null.</p

Characteristics of 41 studies evaluating the association between antidepressant medication use during pregnancy and preterm birth.

<p>Abbreviations: Prosp = Prospective cohort; Retro = Retrospective cohort; depr = depression; AD = antidepressant; SRI = serotonin reuptake inhibitor; TCA = tricyclic antidepressant; NaSSA = Noradrenergic and specific serotonergic antidepressants; SNRI = Serotonin–norepinephrine reuptake inhibitors; NRI = noradrenaline reuptake inhibitors; T = trimester; exp = exposed; TIS = Teratogen Information Service.</p