Video Threads: Asynchronous Video Sharing for Temporally Distributed Teams

Work teams are often geographically distributed, and in some cases, experience large time-zone differences with no overlap in working hours. We explored the use of asynchronous video in temporally distributed teams. We developed VideoThreads, which provides a novel threadbased visualization of video messages. Based on a deployment to four teams, we offer design recommendations and insights about the benefits of asynchronous video sharing. Author Keywords Computer-mediated-communication, video, asynchronous, CSCW, time-shifted collaboration, office and workspace

Effect of apolipoprotein genotype and educational attainment on cognitive function in autosomal dominant Alzheimer’s disease

Abstract Autosomal dominant Alzheimer’s disease (ADAD) is genetically determined, but variability in age of symptom onset suggests additional factors may influence cognitive trajectories. Although apolipoprotein E (APOE) genotype and educational attainment both influence dementia onset in sporadic AD, evidence for these effects in ADAD is limited. To investigate the effects of APOE and educational attainment on age-related cognitive trajectories in ADAD, we analyzed data from 675 Presenilin-1 E280A mutation carriers and 594 non-carriers. Here we show that age-related cognitive decline is accelerated in ADAD mutation carriers who also have an APOE e4 allele compared to those who do not and delayed in mutation carriers who also have an APOE e2 allele compared to those who do not. Educational attainment is protective and moderates the effect of APOE on cognition. Despite ADAD mutation carriers being genetically determined to develop dementia, age-related cognitive decline may be influenced by other genetic and environmental factors