You Can Disappear Here Without Knowing It : Excess, Accommodation, and Assimilation in The Great Gatsby and Less Than Zero

This work discusses the protagonists, economic situations, and investigation of youth in The Great Gatsby and Less Than Zero within the context of Jean Piaget’s cognitive psychological terms “accommodation” and “assimilation.” Assimilation highlights the amoral activities and economics beholden to most members of society in the novels, while accommodation allows a voice amongst the turmoil to clash and express a clear vision of how society should be for the sake of others, maintaining agency, and producing an intelligent and stable populace. By inspecting the use of age in The Great Gatsby and the symbolism behind tanning in Less Than Zero, readers are introduced to protagonists who embody the Piagetian dynamic of accommodation in an otherwise assimilative society. I bridge these novels, eventually discussing what further work can be done through a Piagetian lens. I aim to show how this theory may be utilized in literature to dissect human nature, be it through economic excess or the critique of modern culture in retrospect

Algorithmic randomness, reverse mathematics, and the dominated convergence theorem

We analyze the pointwise convergence of a sequence of computable elements of L^1(2^omega) in terms of algorithmic randomness. We consider two ways of expressing the dominated convergence theorem and show that, over the base theory RCA_0, each is equivalent to the assertion that every G_delta subset of Cantor space with positive measure has an element. This last statement is, in turn, equivalent to weak weak K\"onig's lemma relativized to the Turing jump of any set. It is also equivalent to the conjunction of the statement asserting the existence of a 2-random relative to any given set and the principle of Sigma_2 collection

Exploratory studies to inform full-scale evaluations of complex public health interventions: the need for guidance

No abstract available

Chemical Chaperones Improve Protein Secretion and Rescue Mutant Factor VIII in Mice with Hemophilia A.

nefficient intracellular protein trafficking is a critical issue in the pathogenesis of a variety of diseases and in recombinant protein production. Here we investigated the trafficking of factor VIII (FVIII), which is affected in the coagulation disorder hemophilia A. We hypothesized that chemical chaperones may be useful to enhance folding and processing of FVIII in recombinant protein production, and as a therapeutic approach in patients with impaired FVIII secretion. A tagged B-domain-deleted version of human FVIII was expressed in cultured Chinese Hamster Ovary cells to mimic the industrial production of this important protein. Of several chemical chaperones tested, the addition of betaine resulted in increased secretion of FVIII, by increasing solubility of intracellular FVIII aggregates and improving transport from endoplasmic reticulum to Golgi. Similar results were obtained in experiments monitoring recombinant full-length FVIII. Oral betaine administration also increased FVIII and factor IX (FIX) plasma levels in FVIII or FIX knockout mice following gene transfer. Moreover, in vitro and in vivo applications of betaine were also able to rescue a trafficking-defective FVIII mutant (FVIIIQ305P). We conclude that chemical chaperones such as betaine might represent a useful treatment concept for hemophilia and other diseases caused by deficient intracellular protein trafficking