20 research outputs found
Counts of different isoforms of miRNA cfa-mir-486-5p in the blood sample.
<p>Counts of different isoforms of miRNA cfa-mir-486-5p in the blood sample.</p
Counts of proTRAC piRNA predictions across tissues.
<p>Counts of proTRAC piRNA predictions across tissues.</p
Annotation of the complete set of miRNAs, based on genomic location.
<p>Annotation of the complete set of miRNAs, based on genomic location.</p
Results of the computational prediction of miRNA loci, using miRCat and miRDeep2.
<p>Results of the computational prediction of miRNA loci, using miRCat and miRDeep2.</p
MiRNA expression plots and predicted secondary structures.
<p>Different colours in the plot correspond to different tissues as described in C). Green and purple-labelled bases in the hairpin figure indicate the most abundant read mapping to the 5' and 3' ends; conserved miRNA cfa-miR-371 (A) appears to be absent in heart and shows variable expression levels in the other tissues. B) Plots for a novel miRNA located in chromosome 15, supported by small RNA reads from the brain sample.</p
Workflow for the generation of miRNA expression profiles and secondary structures.
<p>Small RNA reads are first mapped (A) to the hairpin sequences, looking for two peak alignment patterns as shown in B (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0153453#pone.0153453.s004" target="_blank">S4</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0153453#pone.0153453.s005" target="_blank">S5</a> Figs). Expression levels across each hairpin (B) and secondary structures (C) are then derived (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0153453#pone.0153453.s006" target="_blank">S6</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0153453#pone.0153453.s007" target="_blank">S7</a> Figs).</p
Identification of known and novel miRNA loci.
<p>Identification of known and novel miRNA loci.</p
Ertugliflozin and Sitagliptin Co-initiation in Patients with Type 2 Diabetes: The VERTIS SITA Randomized Study
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Ertugliflozin in Patients with Stage 3 Chronic Kidney Disease and Type 2 Diabetes Mellitus: The VERTIS RENAL Randomized Study
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Ertugliflozin Compared with Glimepiride in Patients with Type 2 Diabetes Mellitus Inadequately Controlled on Metformin: The VERTIS SU Randomized Study
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