9 research outputs found
High serum cyclophilin C levels as a risk factor marker for coronary artery disease
Cyclophilins (Cyps) are ubiquitous proteins that belong to the immunophilins family consistently
associated with infammatory and cardiovascular diseases. While levels of CypA have been extensively
studied, less data are available for other Cyps. The purpose of this case-control study was to determine
the relationship of Cyps (A, B, C and D) with coronary artery disease (CAD) and eight infammation
markers. Serum levels of Cyps, interleukins and metalloproteinases were measured in serum collected
from 84 subjects. Participants were divided into two sub-groups based on CAD diagnosis: 40 CAD
patients and 44 control volunteers. Serum levels of CypA, CypB and CypC, IL-1β and IL-6 were
signifcantly higher in CAD patients. Bivariate correlation analysis revealed a signifcant positive
correlation between Cyps and several blood and biochemical parameters. When the ability of Cyps levels
for CAD diagnosis was evaluated, higher sensitivity and selectivity values were obtained with CypC
(c-statistic 0.891, p<0.001) indicating that it is a good marker of CAD disease, while less conclusive
results were obtained with CypA (c-statistic 0.748, p<0.001) and CypB (c-statistic 0.655, p<0.014). In
addition, signifcant correlations of traditional CAD risk factors and CypC were observed. In summary,
high levels of CypC are a risk factor for CAD and therefore it can be proposed as a new biomarker for this
diseaseThe research leading to these results has received funding from the following FEDER cofunded-grants. From Conselleria de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia, 2017 GRC GI-1682 (ED431C 2017/01). From CDTI and Technological Funds, supported by Ministerio de Economía, Industria y Competitividad, AGL2016-78728-R (AEI/FEDER, UE), ISCIII/PI16/01830, ISCIII/PI16/01816 and RTC-2016-5507-2, ITC-20161072. From European Union POCTEP 0161-Nanoeaters -1-E-1, Interreg AlertoxNet EAPA-317-2016, Interreg Agritox EAPA-998-2018, and H2020 778069-EMERTOX. Sandra Gegunde was supported by a fellowship from FIDIS, SpainS