Practical Porous Matrix for Molecular Structure Determination of General Liquid Chemicals

A practical porous crystalline matrix for molecular structure determination of a wide range of liquid chemicals has been set up. We herein report proof-of-concept research on the temperature-dependent single-crystal-to-single-crystal (SCSC) guest exchange of the <i>P</i>- and <i>M</i>-helix-enantiomeric multilayered ensemble with flexible open-channels of the shortest diameter, 4.4 × 4.4 Ų. This landmark ensemble is, to the best of our knowledge, the most efficient, practical, tolerant, and reproducible porous matrix for single crystal structure determination of general liquid compounds via easy SCSC guest exchange without any desolvation process. The innovative channel behaves in a guest-dependent flexible response manner and enables scientists to solve structures of a wide range of liquid chemicals. This paper reports the molecular structures of 41 liquid chemicals including chiral and natural compounds via guest exchange at >75% success rate