3,867 research outputs found
A study of the causal relationship between IT governance inhibitors and its success in Korea enterprises
노트 : Proceedings of the 41st Hawaii International Conference on System Sciences - 2008
행사명 : 41st Hawaii International Conference on System Sc
Continuous Tip Widening Technique for Roll-to-Roll Fabrication of Dry Adhesives
In this study, we reported continuous partial curing and tip-shaped modification methods for continuous production of dry adhesive with microscale mushroom-shaped structures. Typical fabrication methods of dry adhesive with mushroom-shaped structures are less productive due to the failure of large tips on pillar during demolding. To solve this problem, a typical pillar structure was fabricated through partial curing, and tip widening was realized through applying the proper pressure. Polyurethane acrylate was used in making the mushroom structure using two-step UV-assisted capillary force lithography (CFL). To make the mushroom structure, partial curing was performed on the micropillar, followed by tip widening. Dry adhesives with properties similar to those of typical mushroom-shaped dry adhesives were fabricated with reasonable adhesion force using the two-step UV-assisted CFL. This production technology was applied to the roll-to-roll process to improve productivity, thereby realizing continuous production without any defects. Such a technology is expected to be applied to various fields by achieving the productivity improvement of dry adhesives, which is essential for various applications
Competing states for the fractional quantum Hall effect in the 1/3-filled second Landau level
In this work, we investigate the nature of the fractional quantum Hall state
in the 1/3-filled second Landau level (SLL) at filling factor (and
8/3 in the presence of the particle-hole symmetry) via exact diagonalization in
both torus and spherical geometries. Specifically, we compute the overlap
between the exact 7/3 ground state and various competing states including (i)
the Laughlin state, (ii) the fermionic Haffnian state, (iii) the
antisymmetrized product state of two composite fermion seas at 1/6 filling, and
(iv) the particle-hole (PH) conjugate of the parafermion state. All these
trial states are constructed according to a guiding principle called the
bilayer mapping approach, where a trial state is obtained as the
antisymmetrized projection of a bilayer quantum Hall state with interlayer
distance as a variational parameter. Under the proper understanding of the
ground-state degeneracy in the torus geometry, the parafermion state can
be obtained as the antisymmetrized projection of the Halperin (330) state.
Similarly, it is proved in this work that the fermionic Haffnian state can be
obtained as the antisymmetrized projection of the Halperin (551) state. It is
shown that, while extremely accurate at sufficiently large positive Haldane
pseudopotential variation , the Laughlin state loses its
overlap with the exact 7/3 ground state significantly at . At slightly negative , it is shown that the
PH-conjugated parafermion state has a substantial overlap with the exact
7/3 ground state, which is the highest among the above four trial states.Comment: 22 pages, 5 figure
Recent Trends in Tailored Treatments for Helicobacter pylori Infection
The efficacy of the standard triple eradication regimen for Helicobacter pylori (H. pylori) infection is gradually decreasing due to increased antibiotic resistance of H. pylori, which is represented by clarithromycin resistance. This is an important issue for clinicians. Tailored therapies for H. pylori infection, including culture-based susceptibility testing and molecular methods detecting genetic mutations that increase resistance to antibiotics, have been introduced to overcome the high treatment failure rate of the standard triple regimen. The treatment results have been satisfactory. In addition to the H. pylori-related factors, the CYP2C19 gene polymorphism, in terms of host factors, affects the effectiveness of proton pump inhibitors. This article reviews the status of the tailored therapies for H. pylori infection along with the proven therapeutic effects and benefits of such treatments in Korea, where the resistance to antibiotics such as clarithromycin, metronidazole, and quinolone is prevalent
Strong and Reversible Adhesion of Interlocked 3D-Microarchitectures
Diverse physical interlocking devices have recently been developed based on one-dimensional (1D), high-aspect-ratio inorganic and organic nanomaterials. Although these 1D nanomaterial-based interlocking devices can provide reliable and repeatable shear adhesion, their adhesion in the normal direction is typically very weak. In addition, the high-aspect-ratio, slender structures are mechanically less durable. In this study, we demonstrate a highly flexible and robust interlocking system that exhibits strong and reversible adhesion based on physical interlocking between three-dimensional (3D) microscale architectures. The 3D microstructures have protruding tips on their cylindrical stems, which enable tight mechanical binding between the microstructures. Based on the unique 3D architectures, the interlocking adhesives exhibit remarkable adhesion strengths in both the normal and shear directions. In addition, their adhesion is highly reversible due to the robust mechanical and structural stability of the microstructures. An analytical model is proposed to explain the measured adhesion behavior, which is in good agreement with the experimental results
Efficiency of U.S. hospitals between 2001 and 2011
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140031/1/mde2846.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/140031/2/mde2846_am.pd
Catalytic pyrolysis of Laminaria japonica over nanoporous catalysts using Py-GC/MS
The catalytic pyrolysis of Laminaria japonica was carried out over a hierarchical meso-MFI zeolite (Meso-MFI) and nanoporous Al-MCM-48 using pyrolysis gas chromatography/mass spectrometry (Py-GC/MS). The effect of the catalyst type on the product distribution and chemical composition of the bio-oil was examined using Py-GC/MS. The Meso-MFI exhibited a higher activity in deoxygenation and aromatization during the catalytic pyrolysis of L. japonica. Meanwhile, the catalytic activity of Al-MCM-48 was lower than that of Meso-MFI due to its weak acidity
Downregulation of protein kinase CK2 activity induces age-related biomarkers in C. elegans
Studies show that a decrease in protein kinase CK2 (CK2) activity is associated with cellular senescence. However, the role of CK2 in organism aging is still poorly understood. Here, we investigated whether protein kinase CK2 (CK2) modulated longevity in Caenorhabditis elegans. CK2 activity decreased with advancing age in the worms. Knockdown of kin-10 (the ortholog of CK2 beta) led to a short lifespan phenotype and induced age-related biomarkers, including retardation of locomotion, decreased pharyngeal pumping rate, increased lipofuscin accumulation, and reduced resistance to heat and oxidative stress. The long lifespan of age-1 and akt-1 mutants was significantly suppressed by kin-10 RNAi, suggesting that CK2 acts downstream of AGE-1 and AKT-1. Kin-10 knockdown did not further shorten the short lifespan of daf-16 mutant worms but either decreased or increased the transcriptional activity of DAF-16 depending on the promoters of the target genes, indicating that CK2 is an upstream regulator of DAF-16 in C. elegans. Kin-10 knockdown increased production of reactive oxygen species (ROS) in the worms. Finally, the ROS scavenger N-acetyl-L-cysteine significantly counteracts the lifespan shortening and lipofuscin accumulation induced by kin-10 knockdown. Therefore, the present results suggest that age-dependent CK2 downregulation reduces longevity by associating with both ROS generation and the AGE-1-AKT-1-DAF-16 pathway in C. elegans. © Copyright 2017 Elsevier B.V., All rights reserved.1111sci
TCTAP A-033 Reappraisal of Pharmacodynamic Effect of Adjunctive Cilostazol and High-dos Clopidogrel in East Asian ACS Patients
CONSENSUS DEFINITION-BASED CUTOFFS OF HIGH ON-TREATMENT PLATELET REACTIVITY: VALIDATION BETWEEN LIGHT TRANSMITTANCE AND MULTIPLE ELECTRODE AGGREGOMETRIES
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