2,217 research outputs found
Highly effective fat suppression in clinical T1-weighted imaging of ischemic and non-ischemic heart disease with DeSPAIR
Area distribution of the planar random loop boundary
We numerically investigate the area statistics of the outer boundary of
planar random loops, on the square and triangular lattices. Our Monte Carlo
simulations suggest that the underlying limit distribution is the Airy
distribution, which was recently found to appear also as area distribution in
the model of self-avoiding loops.Comment: 10 pages, 2 figures. v2: minor changes, version as publishe
A new CMR protocol for non-destructive, high resolution, ex-vivo assessment of the area at risk simultaneous with infarction: validation with histopathology
Impact of Chromosomal Architecture on the Function and Evolution of Bacterial Genomes
The bacterial nucleoid is highly condensed and forms compartment-like structures within the cell. Much attention has been devoted to investigating the dynamic topology and organization of the nucleoid. In contrast, the specific nucleoid organization, and the relationship between nucleoid structure and function is often neglected with regard to importance for adaption to changing environments and horizontal gene acquisition. In this review, we focus on the structure-function relationship in the bacterial nucleoid. We provide an overview of the fundamental properties that shape the chromosome as a structured yet dynamic macromolecule. These fundamental properties are then considered in the context of the living cell, with focus on how the informational flow affects the nucleoid structure, which in turn impacts on the genetic output. Subsequently, the dynamic living nucleoid will be discussed in the context of evolution. We will address how the acquisition of foreign DNA impacts nucleoid structure, and conversely, how nucleoid structure constrains the successful and sustainable chromosomal integration of novel DNA. Finally, we will discuss current challenges and directions of research in understanding the role of chromosomal architecture in bacterial survival and adaptation
Assessment of semi-quantitative parameters for visual interpretation of stress-perfusion CMR in obstructive coronary artery disease
Assessment of semi-quantitative parameters for visual interpretation of stress-perfusion CMR in obstructive coronary artery disease
Metabolic engineering of <i>Synechocystis</i> sp. PCC 6803 for the production of aromatic amino acids and derived phenylpropanoids
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