PROUD: Effects of preoperative long-term immunonutrition in patients listed for liver transplantation-0

<p><b>Copyright information:</b></p><p>Taken from "PROUD: Effects of preoperative long-term immunonutrition in patients listed for liver transplantation"</p><p>http://www.trialsjournal.com/content/8/1/20</p><p>Trials 2007;8():20-20.</p><p>Published online 27 Aug 2007</p><p>PMCID:PMC2018725.</p><p></p>n after giving informed consent. Study nutrition ends on the day of transplantation. Subjects are randomized to two parallel groups treated for study or control product. Furthermore, patients will be followed for 12 weeks after transplantation

ROC curve analysis of three statistically significant predictors of need for advanced supportive care

A total of 108 patients with imported falciparum malaria were included in the analysis. ROC, receiver operating characteristic.<p><b>Copyright information:</b></p><p>Taken from "Early treatment of imported falciparum malaria in the intermediate and intensive care unit setting: an 8-year single-center retrospective study"</p><p>http://ccforum.com/content/12/1/R22</p><p>Critical Care 2008;12(1):R22-R22.</p><p>Published online 22 Feb 2008</p><p>PMCID:PMC2374613.</p><p></p

VitD concentrations vary dependent on the month of sample obtainment (1A), whereas fluctuations between baseline-VitD and TW24-VitD-values (ΔVitd) are observed as well (1B).

<p>VitD concentrations vary dependent on the month of sample obtainment (1A), whereas fluctuations between baseline-VitD and TW24-VitD-values (ΔVitd) are observed as well (1B).</p

The <i>DHCR7-TT-</i>genotype of the <i>rs12785878</i> SNP shows a significant association to stage of fibrosis.

<p>The <i>DHCR7-TT-</i>genotype of the <i>rs12785878</i> SNP shows a significant association to stage of fibrosis.</p

Patient demographic, biochemical and genetic characteristics.

<p>A VitD deficiency (<20 ng/ml) was observed in 251 (64,1%) out of 391patients. A liver fibrosis stage of 0–2 was observed in 321 (84,9%) out of 378 patients, while 57 (15%) out of 378 patients showed a liver fibrosis stage of 3–4.</p><p><i>Abbreviations</i>: BMI: body-mass-index, ALT: alanine aminotransferase, AST: aspartate aminotransferase, gGT: gamma-glutamyl-transferase, HOMA: homeostatic model assessment of insulin resistance, AP: alkaline phosphatase, TSH: thyroid stimulating hormone, IP10: interferon-γ-inducible-protein-10, HCV: hepatitis C virus.</p><p><i>Missing data</i>: Cholesterol levels were missing in 14 patients, Baseline Vitamin D levels were missing in 7 patients, Baseline IP10 levels were missing in 7 patients, Baseline viral load values were missing in 16 patients, Liver biopsy status was missing in 20 patients. HOMA-index values were missing in 74 patients, Triglyceride levels were missing in 15 patients, AP levels were missing in 4 patients, Ferritin levels were missing in 10 patients, Vitamin D levels on week 24 were missing in 69 patients, IP10 levels on week 1 were missing in 23 patients, IP10 levels on week 4 were missing in 42 patients, TSH values were missing in 6 patients, Genotype of the <i>IL28B</i>-gene was missing in 31 patients, Genotype of the <i>CYP27B1</i>-gene was missing in 32 patients, Genotype of the <i>CYP2R1</i>-gene was missing in 32 patients, Genotype of the <i>DHCR7</i>-genes was missing in 24 patients, Genotype of the <i>CYP24A1</i>-gene was missing in 24 patients, Genotype of the <i>DBP</i>-genes was missing in 24 patients.</p

Uni- and multivariate analysis of predictors of SVR to antiviral therapy.

<p>Only patients with complete data for the remaining covariates (277 out of 398) and with significant variations in the univariate analysis were included in multivariate analyses. Missing data and abbreviations are illustrated in the legend of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087974#pone-0087974-t001" target="_blank">Table 1</a>. A VitD deficiency (<20 ng/ml) was observed in 251 (64,1%) out of 391patients. A liver fibrosis stage of 0–2 was observed in 321 (84,9%) out of 378 patients, while 57 (15%) out of 378 patients showed a liver fibrosis stage of 3–4.</p

Variations of IP10-levels in patients with and without SVR at baseline, week 1 and 4 upon treatment initiation.

<p>Variations of IP10-levels in patients with and without SVR at baseline, week 1 and 4 upon treatment initiation.</p

SNP’s within VitD regulating enzymes in association with baseline VitD values and VitD variations (ΔVitd) upon antiviral therapy.

1,2<p>ΔVitd values were missing in 37 patients, ^3–8ΔVitd values were missing in 66 patients.</p