Plasma pro-LL-37 (%)^a and cytokines (pg/ml) at the time of malignancy diagnosis in patients (n = 35) with different malignancy diagnosis.

a<p>Percentage of the standard.</p>b<p>Cytokine concentrations were tested on 14 patients.</p>c<p>There was no plasma parameter different between lymphoma and solid tumors.</p>d<p>Mann-Whitney test with <i>P</i>-value adjusted with Bonferroni method.</p>*<p><i>P</i><0.05;</p>**<p><i>P</i><0.01;</p>***<p><i>P</i><0.001.</p

Univariable logistic regression with patient-related factors at the time of malignancy diagnosis as independent variables and oral mucositis as the outcome in all patients (n = 104).

<p>BMI, body mass index; BMI-SDS, BMI-standard deviation scores; DMFT (dmft), decayed, missing or filled teeth; GBI, gingival bleeding index; HSV, herpes simplex virus; EBV, Epstein-Barr virus; CMV, cytomegalovirus; SD, standard deviation; OR, odds ratio; CI, confidence interval.</p>a<p>Blood antibody reactivity or PCR analysis. Data of HSV in six patients, EBV in six patients, and CMV in three patients were not available.</p>**<p><i>P</i><0.01,</p>***<p><i>P</i><0.001.</p

Univariable logistic regression with treatment-related factors during chemotherapy as independent variables and oral mucositis as the outcome in all patients (n = 104).

<p>OR, odds ratio; CI, confidence interval.</p>a<p>Variables with OR <1 were not included in multivariable analysis since cytostatic regimens can only be considered as risk indicators for oral mucositis.</p>*<p><i>P</i><0.05,</p>**<p><i>P</i><0.01.</p

Kaplan-Meier curve of patients free from ulcerative oral mucositis with different types of malignancies.

<p>The horizontal axis starts from the beginning of the entire chemotherapy protocol. The oral mucositis (WHO grade >1) free rate is lower in patients with acute leukemia compared to those with lymphoma (<i>P</i> = 0.001) or solid tumors (<i>P</i> = 0.001). The oral mucositis free rates are not different between patients with lymphoma and those with solid tumors (<i>P</i> = 0.212).</p

Multivariable logistic regression with oral mucositis as the outcome in all patients (n = 104).

<p>OR, odds ratio; CI, confidence interval.</p>a<p>Variables that have significant difference in the univariable analysis (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0064918#pone-0064918-t002" target="_blank">Table 2</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0064918#pone-0064918-t003" target="_blank">3</a>) are included.</p>b<p>Variables that are removed from the logistic regression equation in the unadjusted model.</p>*<p><i>P</i><0.05,</p>**<p><i>P</i><0.01,</p>***<p><i>P</i><0.001.</p

Diagnoses of the patients and frequencies of oral mucositis.

<p>ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia.</p>a<p>Treatment protocols containing radiation do not involve orofacial region.</p